Evaluation of Radioprotective Effects of Rajgira (Amaranthus paniculatus) Extract in Swiss Albino Mice

Krishna, A P; Kumar, Ashok

doi:10.1269/jrr.46.233

Cited by 67 publications

(37 citation statements)

References 28 publications

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“…In this study, radiation-induced depressions in blood glutathione, glutathione peroxidase, and SOD, and increases in plasma lipid peroxide products were normalized in the irradiated rats that received combined vitamin E and Se. 25 The observed effect of radiation on the levels of antioxidant enzymes in this study is in consonance with the findings of Kumar 7 and Krishna et al 29 RJ, as a reference antioxidant in this study, protected the hepatic and lung tissues of the irradiated animals.…”

supporting

confidence: 92%

Protective Role of Royal Jelly Against Radiation-Induced Oxidative Stress in Rats

Cihan¹

2013

UHOD

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The aim of this study was to investigate the effects of royal jelly against gamma-radiation induced oxidative damage in liver and lung tissue after total body irradiation. The adult male Sprague Dawley rats were randomly divided into six groups of sixteen animals each; group 1: control group (C), group 2: only irradiated rats (IR), group 3: irradiated rats with royal jelly administration at 25 mg/kg/day (IR+RJ25), group 4: irradiated rats with royal jelly administration at 50 mg/kg/day (IR+RJ50), group 5: only royal jelly administration at 25 mg/kg/day (RJ25), group 6: only royal jelly administration at 50 mg/kg/day (RJ50). Royal jelly (RJ) was administered at a dose of 25 and 50-mg/kg body weight, by gavage for 10 days prior to irradiation and 10 days after irradiation. On the tenth day of study, radiotherapy was applied to the whole-body by single fraction at a dose of 6 Gy. Half of rats were sacrificed at 24 hours and 10 days after irradiation under ether anesthesia. Blood samples were collected and analysed for alanine aminotransferase, aspartate aminotransferase, triygliceride, total cholesterol and gamma glutamyl transpeptidase levels. The lung and liver samples were stored for the measurement of malondialdehyde, glutathione peroxidase, superoxide dismutase and catalase activities. Rats exposed to wholebody irradiation induced a marked liver failure, characterized with a significant increase in serum AST, ALT, cholesterol and triglyceride concentrations, and also they had higher lung and liver MDA and lower GSH-Px, CAT and SOD (p<0.001). Administration of royal jelly resulted in a significant decreased in oxidative stress parameters and biochemical parameters, and certainly increased antioxidant activities. Furthermore, pre-and post-treatment with RJ was more effective than pre-treatment with RJ.These results suggest that royal jelly may probably protect the animals from radiation-induced liver and lung damage. The effects of royal jelly can result from its antioxidant properties.Keywords: Radiotherapy, Royal jelly, Rat, Liver, Lung, Protector ÖZET S›çanlarda Radyasyonun ‹ndükledi¤i Oksidatif Strese Karfl› Ar› Sütünün Koruyucu RolüBu araflt›rmada, tüm vücut ›fl›nlamas› yap›lan s›çanlarda ar› sütünün akci¤er ve karaci¤er hasar›na karfl› koruyucu rolü olup olmad›¤› belirlenmeye çal›fl›ld›. Her birinde 16 adet eriflkin, erkek Sprague Dawley s›çan bulunan 6 grup bu çal›flmaya dâhil edildi; Grup 1: kontrol grubu (K), grup 2: sadece radyasyon uygulanan (RT), Grup 3: radyasyon ile birlikte 25 mg/kg/gün ar› sütü verilen (RT+AS25), Grup 4: radyasyon ile birlikte 50 mg/kg/gün ar› sütü verilen (IR+AS50), Grup 5: sadece 25 mg/kg/gün ar› sütü verilen (AS25) ve Grup 6: sadece 50 mg/kg/gün ar› sütü (AS50) verilen grup olarak belirlendi. Ar› sütü s›çanlara ›fl›nlamadan 10 gün önce ve sonra günde bir defa gavajla verildi. Onuncu günde s›çanlara, tek fraksiyonda ve doz 6 Gy olacak flekilde tüm vücut ›fl›nlamas› yap›ld›. S›çanlar›n yar›s› ›fl›nlamadan 24 saat sonra, kalan yar›s› ise 10. günde eter anestezisi alt›nda ...

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supporting

confidence: 92%

Protective Role of Royal Jelly Against Radiation-Induced Oxidative Stress in Rats

Cihan¹

2013

UHOD

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“…A number of radioprotective compounds that have been identified from medicinal plants are known to elicit strong antioxidant potentials, these include; Phyllantus amaurus, Tinospora cordifolia, Hibiscus sabdariffa, Aaegle marmelos, Vernonia amygdalina, Amarathus paniculatus, etc. [8][9][10][11][12] In view of the above, it is pertinent to look inwards to other medicinal plants that can protect against radiation.…”

mentioning

confidence: 99%

Protective Effect of Kolaviron, a Biflavonoid from Garcinia kola Seeds, in Brain of Wistar Albino Rats Exposed to Gamma-Radiation

Adaramoye

2010

Biological & Pharmaceutical Bulletin

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This study was designed to evaluate the protective effect of kolaviron (KV), a biflavonoid from Garcinia kola seeds, against g g-radiation (5 Gy)-induced oxidative stress in brain of Wistar rats. Vitamin C (VC) served as standard antioxidant. Forty-four rats were divided into 4 groups of 11 animals each. One group was un-irradiated (normal), two groups were treated with KV and VC (250 mg/kg) for 6 weeks prior to and 8 weeks after irradiation, and fourth group was only irradiated. Rats were sacrificed 1 and 8 weeks after irradiation. Cellular alterations were monitored using changes in the levels of malondialdehyde (MDA)-an index of lipid peroxidation, superoxide dismutase (SOD), glutathione-S-transferase (GST), reduced glutathione (GSH), catalase (CAT), alanine and aspartate aminotransferases (ALT and AST), urea and creatinine. MDA levels increased significantly (pϽ Ͻ0.05) by 90% and 151% after 1 and 8 weeks of irradiation. Furthermore, levels of GSH and antioxidant enzymes were significantly (pϽ Ͻ0.05) decreased in g g-irradiated animals. GSH and GST decreased by 61% and 43% after 1 week, and by 75% and 74%, after 8 weeks of exposure, respectively. g g-Irradiation decreased SOD and CAT levels by 53% and 68%, respectively, and caused significant ( pϽ Ͻ0.05) increases in serum ALT, AST and urea after 8 weeks of exposure. Treatment with KV and VC significantly decreased the levels of MDA, ALT, AST and urea. The antioxidant indices were significantly ameliorated in KV-treated animals. These data suggest that kolaviron may protect against g g-radiation-induced oxidative stress in brain of exposed rats.

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“…A parameter indicating the effect of radiation protection in different situations is defined by the Equation 1 (16): in which D sample is the dose of radiation expected to cause death to 50 percent of an exposed sample groups within 30 days and D control is the dose of radiation expected to cause death to 50 percent of an exposed control groups within 30 days:…”

Section: Determination Of the Dose-reduction Factor (Drf)mentioning

confidence: 99%

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

Oladi

Sazgarnia

Nasiri

et al. 2016

Iran Red Crescent Med J

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Background: Ionizing radiation has become an essential part of modern medicine. However, applying the effective dose of ionizing radiation is compromised by its inevitable radiation-induced damage to normal tissues. Natural products with free radical scavenging, antioxidant activities, and immune stimulatory effects offer suitable radio-protective effects. Objectives: This study was designed to evaluate the in vivo radio-protective activity of lycopene, a naturally dietary carotenoid, against whole-body gamma-irradiation-induced mortality and sickness in mice. Methods: In this animal experimental study, lycopene was extracted from tomato paste, characterized, and then administered to mice. Consecutively, 80 healthy adult male mice were recruited and irradiated individually, and then monitored for irradiation sickness and survival parameters. Results: Pretreatment with 7 mg/kg dose of lycopene 7 days before irradiation was found to reduce the severity of symptoms of radiation sickness in a 30-day post-radiation monitoring. Lycopene treatment increased the survival rate. At the radiation dosage of 8 and 9 Gy, the difference between the survival rates of control and sample groups became significant after day 15 and 25. Lycopene was also shown to have a protective effect on white blood cell count against 8 and 9 Gy gamma radiations. Conclusions: Natural and exhibiting whole-body radio-protective activity, lycopene can be proposed as an effective radio-protector in healthy people who are exposed to radiation, such as radiographers, nuclear pharmacists, and radiologists.

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Evaluation of Radioprotective Effects of Rajgira (Amaranthus paniculatus) Extract in Swiss Albino Mice

Cited by 67 publications

References 28 publications

Protective Role of Royal Jelly Against Radiation-Induced Oxidative Stress in Rats

Protective Role of Royal Jelly Against Radiation-Induced Oxidative Stress in Rats

Protective Effect of Kolaviron, a Biflavonoid from Garcinia kola Seeds, in Brain of Wistar Albino Rats Exposed to Gamma-Radiation

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

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