2016
DOI: 10.1002/jrs.4831
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Evaluation of Raman spectroscopy for prediction of antitumor response to silibinin and its nanoparticulates in DMBA‐induced oral carcinogenesis

Abstract: Raman spectroscopy is a vibrational spectroscopic technique that can be used to monitor the therapeutic efficacy of anticancer drugs during carcinogenesis in a non‐invasive and label‐free manner. The present study aims to investigate the biochemical changes exerted upon free silibinin (SIL) and its nanoparticulate (SILNPs) treatment against 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced oral carcinogenesis in the fingerprint region of 1800–500 cm−1 using HE‐785 Raman spectrometer. Raman spectra differed signifi… Show more

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Cited by 4 publications
(4 citation statements)
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References 56 publications
(83 reference statements)
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“…Gohulkumar et al carried out an evaluation of Raman spectroscopy for the prediction of antitumor response to silibinin and its nanoparticulates in DMBA‐induced oral carcinogenesis. Their results more generally demonstrate that Raman spectroscopy associated with PC‐LDA diagnostic algorithms could be a valuable tool for rapid and sensitive detection of specific biomolecular changes at the molecular level in response to the presence of an anticancer drug . Jansen van Vuuren and co‐workers studied the chemical and mechanical properties of snake fangs.…”
Section: Biosciencesmentioning
confidence: 99%
See 1 more Smart Citation
“…Gohulkumar et al carried out an evaluation of Raman spectroscopy for the prediction of antitumor response to silibinin and its nanoparticulates in DMBA‐induced oral carcinogenesis. Their results more generally demonstrate that Raman spectroscopy associated with PC‐LDA diagnostic algorithms could be a valuable tool for rapid and sensitive detection of specific biomolecular changes at the molecular level in response to the presence of an anticancer drug . Jansen van Vuuren and co‐workers studied the chemical and mechanical properties of snake fangs.…”
Section: Biosciencesmentioning
confidence: 99%
“…Their results more generally demonstrate that Raman spectroscopy associated with PC-LDA diagnostic algorithms could be a valuable tool for rapid and sensitive detection of specific biomolecular changes at the molecular level in response to the presence of an anticancer drug. [67] Jansen van Vuuren and co-workers studied the chemical and mechanical properties of snake fangs. As a preliminary study, the fangs of four species of snakes and a human tooth were investigated through nanoindentation and Raman spectroscopy.…”
Section: Cells Bacteria and Virusesmentioning
confidence: 99%
“…Raman spectroscopy has been applied to molecular imaging and analytics for biomedical imaging . Recently, surface‐enhanced Raman scattering (SERS) has been introduced to study the interfacial interactions between biologically important species and nanostructured materials . Over the past several decades, the chemical synthesis has led to the discovery and development of cancer therapeutic agents based on the understanding of drug uptake, molecular interaction, and cellular process .…”
Section: Introductionmentioning
confidence: 99%
“…[1] Recently, surface-enhanced Raman scattering (SERS) has been introduced to study the interfacial interactions between biologically important species and nanostructured materials. [2][3][4][5][6] Over the past several decades, the chemical synthesis has led to the discovery and development of cancer therapeutic agents based on the understanding of drug uptake, molecular interaction, and cellular process. [7] Much attention has been paid to the application of nanoparticulate intracellular delivery of anticancer drugs to cure cancers.…”
Section: Introductionmentioning
confidence: 99%