Evaluation of Recombinant Human Lactoferricin Culture as a Substitute for Antibiotic in Pig Starter Diets

Hong, J. W.; Kim, I.H.; Hwang, In-Joon; Lee, J.H.; Kim, J.H.; Kwon, O. S.; Lee, S.H.

doi:10.5187/jast.2003.45.4.537

Cited by 4 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, they are suitable as feed additive for livestock and poultry. Recent research of AMP supplementations has demonstrated that AMP could increase the growth performance of piglets (Hong, Kim, Kwon, & Hwang, 2003; Tang et al., 2009; Yoon et al., 2012) and broilers and reduce the number of intestinal pathogens of chickens (Wang et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of Antimicrobial peptides on egg production, egg quality and caecal microbiota of hens during the late laying period

Chen

Zhan

et al. 2020

Animal Science Journal

View full text Add to dashboard Cite

Antibiotics are widely used for animal production. However, the abuse of feeding antibiotics has resulted in drug resistance of pathogens, resulting in an imbalance of the intestinal flora of livestock and poultry (Chang, Wang, Regev-Yochay, Lipsitch, & Hanage, 2015) leaving antibiotic residues in livestock products and causing environmental pollution (Martinez, 2009). Therefore, researchers attempt to seek better antibiotic alternatives for laying hens. Antimicrobial peptides (AMP) are gene-encoded, ribosomal synthesized polypeptides, which usually have the common functions: anti-bacteria, anti-fungi and anti-virus (Hassan, Kjos, Nes, Diep,

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Antimicrobial peptides on egg production, egg quality and caecal microbiota of hens during the late laying period

Chen

Zhan

et al. 2020

Animal Science Journal

View full text Add to dashboard Cite

show abstract

“…Currently, 1711 AMP have been identified from a wide range of organisms (; accessed February 2011). Recent research demonstrated that AMP could improve the growth performance of piglets ( 4 , 5 ) , growing–finishing pigs ( 6 ) , chickens ( 7 ) and fishes ( 8 ) , and the integrity of intestinal surfaces and intestinal mucosal response of chickens ( 7 , 9 , 10 ) . It seems that AMP are suited to be alternatives to AGP, but the use of AMP from natural sources is not at present cost-effective.…”

mentioning

confidence: 99%

Dose–response effects of an antimicrobial peptide, a cecropin hybrid, on growth performance, nutrient utilisation, bacterial counts in the digesta and intestinal morphology in broilers

Wen

2012

Br J Nutr

View full text Add to dashboard Cite

The aim of the present study was to evaluate the feasibility of an antimicrobial peptide, cecropin A(1-11)-D(12-37)-Asn (CADN), as an alternative to antibiotic growth promoter (AGP) in poultry diets. A total of 1500 14-d-old indigenous male chickens (222 (SD 13) g) were randomly allocated to five groups with five replicate cages of sixty birds each, and fed ad libitum five grower diets and subsequently five finisher diets for 14 d each. The diets were made up by supplementing their basal diets with a CADN liquid sample (CADNL) at 0, 2, 4, 6 and 8 ml/kg, respectively. During the feeding period, a metabolic experiment was carried out to determine the apparent digestibility of diethyl ether extract, nitrogen retention and apparent metabolisable energy of the diet sample fed to each cage of chicks. At the end of the feeding experiment, one chick from each cage was killed for bacteriological, light microscopic and scanning electron microscopic examination of the intestinal villi. CADN had a negative linear, positive quadratic and negative linear effect on feed intake (F), weight gain (G) and feed:gain ratio (F:G), respectively, for the growers; it had a quadratic effect on F, G or F:G for the finishers; it increased nutrient utilisation for both growers and finishers; it decreased aerobic bacterial counts in both jejunal and caecal digesta in a dose-dependent manner; it enhanced intestinal villus heights in a dose-dependent manner and made the duodenum villi of the CADNL8 group at 42 d appear as a netted leaf-like structure. CADN is therefore a possible alternative to AGP in broiler feeds.

show abstract

“…Consequently, new concepts have been developed aiming to promote animal health and to secure growth performance, feed efficiency, and product quality as well. Several naturally occurring compounds have been shown to affect the composition and activity of the microflora in the gastrointestinal tract of pigs such as diet acidification (Tsiloyiannis et al, 2001), mannan-oligosaccharides (Ko et al, 2000), herbs (Wenk, 2003), minerals (Hill et al, 2001), direct-fed microbial (Xuan et al, 2001) and lactoferricin (Hong et al, 2003). Recently, livestock industry has been interested in egg yolk antibody as nonantibiotic feed additives.…”

Section: Methodsmentioning

confidence: 99%

Evaluation Effects of Spray-dried Egg Protein Containing Specific Egg Yolk Antibodies as a Substitute for Spray-dried Plasma Protein or Antibiotics in Weaned Pigs

Hong¹,

Kwon²,

Min³

et al. 2004

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

In Exp. 1, a total of 36 pigs (6.55±0.10 kg average initial body weight and 21 d average age) were used in a 14 d growth study to determine the effects of replacing spray-dried plasma protein (SDPP) with spray-dried egg protein containing specific egg yolk antibody (SDEP) on growth performance and nutrient digestibility in weaned pigs. The pigs were blocked by weight and assigned to treatments based on sex. There were three pigs per pen and four pens per treatment. Dietary treatments were 0, 3, or 6% SDEP and contained 6, 3, or 0% SDPP, respectively. Through the entire experimental period, average daily gain (ADG), average daily feed intake (ADFI), and gain/feed tended to decrease as the concentration of SDEP increased in the diets. However, there were no significant differences among the treatments (p>0.05). As the addition of SDEP in the diets increased, apparent digestibilities of dry matter (DM) and nitrogen (N) were decreased without significant (p>0.05). For Exp. 2, 36 pigs (2.63±0.04 kg average initial body weight and 10 d average age) were used in a 14 d growth study to determine the effects of antibiotic replacement with SDEP on growth performance and nutrient digestibility in early-weaned pigs. The pigs were blocked by weight and assigned to treatments based on sex. There were three pigs per pen and four pens per treatment. Dietary treatments included 1) ANTIBIOTIC (corn-dried whey-soybean meal based diet+0.08% antibiotics, 4 mg of tiamuline hydrogen fumarate; 10 mg of sulfadimidine per kg of complete diet), 2) SDEP0.1 (corndried whey-SBM based diet+0.1% SDEP), and 3) SDEP0.2 (corn-dried whey-SBM based diet+0.2% SDEP). ADG and gain/feed of pigs fed the SDEP0.2 diet were higher than for pigs fed the ANTIBIOTIC diet without significant (p>0.05). Pigs fed the diet with SDEP0.2 tended to have increased apparent digestibilities of DM and N compared to pigs fed the ANTIBIOTIC diet without significant (p>0.05). In conclusion, the dietary SDEP seemed to be partial replacing the SDPP portion of high nutrient dense diet for weaned pigs. Also, dietary SDEP seemed to be approximately 0.2% or more when the pigs fed the antibiotic-free diet for early-weaned pigs.

show abstract

Evaluation of Recombinant Human Lactoferricin Culture as a Substitute for Antibiotic in Pig Starter Diets

Cited by 4 publications

References 13 publications

Effects of Antimicrobial peptides on egg production, egg quality and caecal microbiota of hens during the late laying period

Effects of Antimicrobial peptides on egg production, egg quality and caecal microbiota of hens during the late laying period

Dose–response effects of an antimicrobial peptide, a cecropin hybrid, on growth performance, nutrient utilisation, bacterial counts in the digesta and intestinal morphology in broilers

Evaluation Effects of Spray-dried Egg Protein Containing Specific Egg Yolk Antibodies as a Substitute for Spray-dried Plasma Protein or Antibiotics in Weaned Pigs

Contact Info

Product

Resources

About