Evaluation of sE-Selectin and sICAM-1 as Parameters for Renal Function

Abstract

Introduction. In order to monitor acute renal failure, intensive care patients were examined, and routine as well as specialized parameters were compared. Materials and Methods. Thirty-three patients at the Surgical Intensive Care Unit (ICU) were examined daily over the entire period for which they stayed in the ICU. The patients were retrospectively classified as being either with or without acute renal failure. Group 1 consisted of 22 patients who resided in the ICU for 11-15 (median 14) days without ARF. Group 2 consisted of 11 patients who developed an ARF during their stay of 13-18 (median 16) days in the ICU. In addition to the routine parameters of diuresis, serum creatinine/urea, and clearance of creatinine, specialized parameters for kidney function, including the excretion rates of α1-microglobulin, Nacetyl-β-D-glucosaminidase, and total protein, were compared with the excretion rate of soluble ICAM-1 and sESelectin. Results. Diuresis, serum creatinine, urea, and enzyme elimination were pathological among patients with ARF. Already on the day of admission, raised elimination rates of sICAM-1 were found in the urine of patients who had developed an ARF. While high values were still shown upon discharge, levels kept falling among patients without ARF. Clearly raised values were also shown for sE-Selectin compared to patients without ARF. Conclusions. sICAM-1 and sE-Selectin as supplementary parameters indicating renal function revealed early signs of kidney damage. These parameters may play a major role in the development of novel therapeutic approaches for ARF (antibodies against ICAM-1 or sE-Selectin).

A common missense single nucleotide polymorphism in the E-selectin gene is significantly associated with essential hypertension in the Han population but only weakly associated in the Uygur population

“…This is consistent with the established relationship between E-selectin gene polymorphism or serum soluble E-selectin level and atherosclerotic vascular disease, such as coronary heart disease, ischemic stroke and kidney injury. 6,17,18 Therefore, E-selectin is intricately involved in the etiology of hypertension.…”

Correlation between the Degree of Glycocalyx Damage and the Incidence of Acute Kidney Injury in Sepsis Patients in the Intensive Care Unit: A Review of Syndecan-1 and sICAM-1

“…Studies investigating their use as biomarkers reveal that they can be used to monitor endothelial damage of specific organs (such as L-selectin for ARDS) [24]. Soluble ICAM-1 and soluble E-selectin can be used as additional parameters indicating [25]. De Pablo et al showed that glycocalyx damage could be predicted by markers ICAM-1, which at ICU admission, sE-selectin, sVCAM-1, and sICAM-1 in patients with infectious SIRS were significantly higher than that found in patients with non-infectious SIRS [26].…”

The Mechanism of Spleen Injury in Rabbits with Acute Renal Failure

“…The results suggest that during the process of ARF, PMN in spleen tissue increased robustly, which may be involved in the hemorheological disturbances 15 or the overexpression of intercellular adhesion molecules. 17 The PMN sequestrated in spleen tissues can release proinflammatory mediators and therefore arouse inflammatory cascade effects. These events will exacerbate the excessive production of free radical species.…”