Evaluation of separation and purification processes in the antibiotic industry

Bienkowski, Paul R.; Lee, Douglas D.; Byers, Charles H.

doi:10.1007/bf02930830

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…In biotechnology, to effectively use IL‐based ABS, beforehand experimental work is required to optimize the system parameters so as to ensure a selective extraction of the products of biotechnological interest. Among added‐value metabolites are pharmaceutical drugs, namely antibiotics, and of which tetracyclines (TC) comprise a successful class . TC are a family of polyketide antibiotics produced by Streptomyces genus of actinobacteria .…”

Section: Introductionmentioning

confidence: 99%

“…Among added-value metabolites are pharmaceutical drugs, namely antibiotics, and of which tetracyclines (TC) comprise a successful class. 35 TC are a family of polyketide antibiotics produced by Streptomyces genus of actinobacteria. 36 TC was first isolated in 1948 37 and differed from the existing antibiotics due to the broad spectrum for antimicrobial activity and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline

Marques

Mourão

Neves

et al. 2013

Biotechnology Progress

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Aqueous biphasic systems (ABS) using ionic liquids (ILs) offer an alternative approach for the extraction, recovery, and purification of biomolecules through their partitioning between two aqueous liquid phases. In this work, the ability of a wide range of ILs to form ABS with aqueous solutions of Na2 CO3 was evaluated. The ABS formed by IL + water + Na2 CO3 were determined at 25°C, and the respective solubility curves, tie-lines, and tie-line lengths are reported. The studied ILs share the common chloride anion, allowing the IL cation core, the cation isomerism, the presence of functionalized groups, and alkyl side chain length effects to be evaluated. An increase in the cation side alkyl chain length leads to a higher ability for liquid-liquid demixing whereas different positional isomers and the presence of an allyl group have no major influence in the phase diagrams behavior. Quaternary phosphonium- and ammonium-based fluids are more able to form an ABS when compared with imidazolium-, pyridinium-, pyrrolidinium-, and piperidium-based ILs. Moreover, the presence of an aromatic cation core has no major contribution to the formation of ABS when compared to the respective nonaromatic counterparts. Finally, to appraise on the systems applicability in downstream processing, selected systems were used for the partitioning of tetracyclines (neutral and salt forms) - a class of antibiotics produced by bacteria fermentation. Single-step extraction efficiencies for the IL-rich phase were always higher than 99% and confirm the great potential of ILs to be applied in the biotechnological field.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline

Marques

Mourão

Neves

et al. 2013

Biotechnology Progress

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“…Although there have been efforts and calls to hasten the development of newer antibiotics [ 5 , 6 , 7 ], the discoveries alone could hardly be deemed a panacea for subduing microbes in the “AMR war”. Moreover, the discovery processes, even if eventually successful, are capital-intensive and concurrently less financially rewarding in the contemporary scheme of pervasive microbial adaptations [ 8 , 9 , 10 ]. One revolutionary approach that has “made headlines” in the infectious diseases community is phage therapy [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria

Osman,

Kotey,

Odoom

et al. 2023

Antibiotics

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The growing threat of antibiotic resistance is a significant global health challenge that has intensified in recent years. The burden of antibiotic resistance on public health is augmented due to its multifaceted nature, as well as the slow-paced and limited development of new antibiotics. The threat posed by resistance is now existential in phage therapy, which had long been touted as a promising replacement for antibiotics. Consequently, it is imperative to explore the potential of combination therapies involving antibiotics and phages as a feasible alternative for treating infections with multidrug-resistant bacteria. Although either bacteriophage or antibiotics can potentially treat bacterial infections, they are each fraught with resistance. Combination therapies, however, yielded positive outcomes in most cases; nonetheless, a few combinations did not show any benefit. Combination therapies comprising the synergistic activity of phages and antibiotics and combinations of phages with other treatments such as probiotics hold promise in the treatment of drug-resistant bacterial infections.

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Antibiotic Against Gram‐Negative Bacteria

Faiyaz

Gupta

2019

High Value Fermentation Products

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Evaluation of separation and purification processes in the antibiotic industry

Cited by 5 publications

References 9 publications

Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline

Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline

The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria

Antibiotic Against Gram‐Negative Bacteria

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