Evaluation of serum 25‐hydroxyvitamin <scp>D</scp> levels in vitiligo patients with and without autoimmune diseases

Saleh, Hanan; Fattah, Nermeen S. A. Abdel; Hamza, Heba-Tullah M. M.

doi:10.1111/phpp.12016

Cited by 62 publications

(79 citation statements)

References 23 publications

(47 reference statements)

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“…[12][13][14][15][16][17][18][19][20] There was no significant decrease in vitamin D levels in patients with associated autoimmune comorbidity in our study. Similar results have been found by Khurrum et al, Saleh et al as well as Beheshti et al 7,18,19 All other studies had found a significant decrease in vitamin D levels in patients having comorbid autoimmune conditions. 12-20, Further studies having a larger sample size may reveal a correlation in the Indian context.…”

Section: Discussionsupporting

confidence: 80%

“…Similar results were obtained in a study by Finamor et al as well as Takczi et al 9,11 However the majority of patients in other studies had a mean age below 35. [6][7][8][12][13][14][15][16][17][18][19][20] This may reflect certain social attitudes towards the disease i.e. hesitancy to consult local physicians regarding vitiligo, or presenting to a tertiary center only after prolonged native treatment.…”

Section: Discussionmentioning

confidence: 99%

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A case control study of vitamin D levels in patients with vitiligo

Karthikeyan

2017

Int J Res Dermatol

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Background: Vitiligo is fairly commonly encountered disorder of pigmentation resulting in the presence of numerous depigmented macules and patches over the body. Vitamin D is an essential hormone synthesized in the skin. Levels of vitamin D have been found to be low in patients with vitiligo. The purpose of this study is to evaluate if vitamin D levels have any association with vitiligo, by estimating the levels of vitamin D in patients with vitiligo, and correlating type of vitiligo with vitamin D levels.Methods: A hospital based case control study was done in the Dermatology outpatient department of a tertiary center in South India from October 2014 to May 2016. About 45 consenting patients who fulfilled the inclusion criteria were chosen for the study. About 45 age and sex matched consenting individuals without vitiligo were chosen as controls from the Dermatology outpatient department. A detailed history and clinical examination of all the consenting subjects was done. Blood samples were collected from both the cases and controls by venepuncture and sera separated. The levels of Vitamin D were estimated using a vitamin D ELISA kit.Results: There was no statistically significant difference in vitamin D levels between patients and controls. There was no correlation between type of vitiligo and vitamin D value. Conclusions: Vitamin D does not appear to have any role in vitiligo patients in this study.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

A case control study of vitamin D levels in patients with vitiligo

Karthikeyan

2017

Int J Res Dermatol

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“…There are very few studies evaluating serum vitamin D levels in vitiligo patients [9, 10]. Ustun et al .…”

Section: Discussionmentioning

confidence: 99%

“…Significantly lower serum vitamin D levels were seen in the patients relative to controls. The authors speculated on the possibility of vitamin D supplementation for the treatment of vitiligo patients in the future [10]. …”

Section: Discussionmentioning

confidence: 99%

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The role of serum vitamin D levels in vitiligo

Karagün¹,

Ergin²,

Baysak³

et al. 2016

pdia

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IntroductionVitiligo is a common acquired pigmentary skin disorder. Vitamin D is responsible for skin pigmentation, increases tyrosinase activity and melanogenesis, and exhibits immunoregulatory functions. Low levels of vitamin D are associated with many autoimmune diseases, including systemic lupus, diabetes mellitus, rheumatoid arthritis, multiple sclerosis and alopecia areata. Few reports have evaluated serum vitamin D levels in vitiligo patients, and their results are conflicting.AimTo evaluate serum vitamin D levels of vitiligo patients and compare the results with controls.Material and methodsIn total, 50 vitiligo patients and 47 controls were enrolled in the study. Vitamin D levels were measured from blood samples. Group comparisons were performed using appropriate statistical methods.ResultsThe patients had lower serum vitamin D levels than the controls, but this difference was not significant (p = 0.570).ConclusionsIt remains unknown whether vitamin D deficiency causes vitiligo. Larger controlled studies are required to prove whether low circulating vitamin D is a causative factor in vitiligo.

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Serum vitamins and trace elements in vitiligo patients: A systematic review and meta‐analysis of observational studies

Iraji,

Seyedyousefi,

Heidari

2024

JEADV Clinical Practice

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Vitiligo is one of the most common pigmentary skin disorders, which significantly impacts the quality of life. The aetiology and pathophysiology of vitiligo are still unclear, but one of the proposed mechanisms is oxidative damage interrupting melanogenesis. The purpose of this study was to demonstrate the serum levels of trace elements and vitamins and to systematically review the evidence comparing vitiligo patients with a healthy group. We comprehensively retrieved all studies related to vitiligo and the serum levels of vitamins and minerals from databases such as PubMed, EMBASE, Scopus, Web of Science, Magiran, SID and ISC up to December 2022. Quality assessment and data extraction were conducted by two independent reviewers. Pooled standard mean differences with 95% confidence intervals were estimated using random‐effects models. Our meta‐analysis revealed no significant differences in serum levels of Vitamin B12 and copper. It was concluded that serum concentrations of Vitamin D, Vitamin E, and zinc were lower in vitiligo patients. Conversely, these patients exhibited higher levels of selenium and folic acid compared with healthy individuals. These results might affect the potential use of vitamin and mineral supplementation in vitiligo treatment.

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Evaluation of serum 25‐hydroxyvitamin D levels in vitiligo patients with and without autoimmune diseases

Abstract: Deficient serum 25(OH)D levels are present in vitiligo patients with and without systemic autoimmune diseases. Accordingly, screening for vitamin D deficiency seems of value in vitiligo patients for the possibility of vitamin D supplementation.

Cited by 62 publications

References 23 publications

A case control study of vitamin D levels in patients with vitiligo

A case control study of vitamin D levels in patients with vitiligo

The role of serum vitamin D levels in vitiligo

Serum vitamins and trace elements in vitiligo patients: A systematic review and meta‐analysis of observational studies

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