Evaluation of serum electrolyte levels in iron deficiency anemia patients.

Rafiq, Maryam; Arooj, Amna; Tahir, Qurrat-ul-Ain; Fayyaz, Nudrat; Samad, Afra; Bashir, Sibgha

doi:10.29309/tpmj/2021.28.05.5702

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…One-third of the global population is suffering from anemia disease, which affects more than two billion people worldwide with mortality around 800,000 per year [16]. Some studies have shown that anemia is an imbalance in the serum electrolyte levels, which is the alteration in red cell membrane-bound sodium-potassium adenosine triphosphatase pump activity that governs intra-and extracellular cation homeostasis [17]. Most of the earlier studies are based on meta-analysis or multivariate analysis that may not be able to identify the effects of SNa on the heart, diabetes, and anemia patients [18,19].…”

Section: Introductionmentioning

confidence: 99%

Role of serum sodium on heart, anemia, and diabetes patients

Das,

Medda

et al. 2023

Academia Medicine

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This article examines the role of serum sodium (SNa) on heart, anemia, and diabetes patients based on a real data set of 299 patients and probabilistic modeling. It is derived herein that mean SNa is positively associated with the marginal effects of platelets count (PLC) (P = 0.0019), anemia status (ANS) (P = 0.1053) (partially), creatinine phosphokinase (CRP) (P = 0.0462), smoking habit (SMH) (P= 0.1017), SEX (P = 0.0029), and the joint interaction effects (JIEs) of ejection fraction (EJF) and the status of high blood pressure (HBP), i.e., EJF*HBP (P = 0.1398); ANS and death event (DEE), i.e., ANS*DEE (P = 0.0009); age and time to follow-up (TTF), i.e., AGE*TTF (P = 0.0700); age and serum creatinine (SEC), i.e., AGE*SEC (P = 0.0901); EJF and SEC, i.e., EJF*SEC (P = 0.0044); and CRP and TTF, i.e., CRP*TTF (P = 0.0021). Mean SNa is negatively associated with the marginal effects of DEE (P = 0.0001), TTF (P= 0.0521), SEC (P = 0.0028), diabetes status (DIS) (P = 0.0121), and the JIEs of PLC*ANS (P = 0.1064), CRP*SMH (P = 0.0274), CRP*HBP (P = 0.0044), AGE*PLC (P = 0.0811), AGE*SEX (P = 0.0008), AGE*CRP (P = 0.0463), and EJF*PLC (P = 0.0420). The variance of SNa is marginally positively associated with AGE (P = 0.0933), DEE (P = 0.1408), and the JIEs of AGE*ANS (P = 0.0575), EJF*SEX (P = 0.1001), SEC*SMH (P = 0.0091), EJF*TTF (P = 0.0008), CRP*DIS (P = 0.0039), EJF*DEE (P = 0.0022), and SEC*DIS (P = 0.0001). Also the variance of SNa is marginally negatively associated with ANS (P = 0.0631), EJF (P = 0.0008), DIS (P = 0.0548), PLC (P = 0.0023), SMH (P = 0.0242), TTF (P = 0.0018), CRP (P = 0.0027), and the JIEs of AGE*DEE (P = 0.0003) and SEC*SEX (P = 0.1327). SNa maintains a complex relationship with different patients and factors, and they have both marginal and JIEs on SNa. Medical practitioners and researchers should care about the complicated functional roles of SNa.

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Section: Introductionmentioning

confidence: 99%

Role of serum sodium on heart, anemia, and diabetes patients

Das,

Medda

et al. 2023

Academia Medicine

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“…Lethargy, fatigue, and muscle cramps are examples of moderate symptoms that can result from an alteration in serum electrolyte levels. Severe symptoms include irregular heartbeat, disorientation, convulsions, and even death [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Serum Electrolytes and Glycated Hemoglobin Level in Non-diabetic Iron-Deficient Anaemic Patients

Patil¹,

Biradar²,

Holyachi³

et al. 2023

Cureus

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Introduction: The WHO has recognised iron deficiency anaemia (IDA) as the most common nutritional deficiency in the world, with 30% of the population being affected by this condition. The patient's glycemic status during the past three months is shown by the glycated haemoglobin A1C (HbA1c) test. According to several studies, iron deficiency can increase HbA1C levels without affecting blood sugar levels. HbA1C levels of ≥ 6.5% have been approved by the American Diabetes Association (ADA) as a diagnostic indicator for diabetes mellitus (DM). An imbalance in serum electrolyte levels and anaemia have been linked by several studies. Aim: To analyze the effect of iron deficiency anaemia on HbA1c levels and serum electrolytes in an adult non-diabetic population. Methods: This was a descriptive cross-sectional study conducted in Shri BM Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India from January 2021 to June 2022. A total of 65 moderate to severe normoglycemic iron deficiency anemia patients between 18 to 75 years were enrolled in the study after fulfilling inclusion and exclusion criteria. A detailed history, clinical and biochemical examination was performed including HbA1c levels. The results were pooled and statistical analyses were performed using Statistical Package for Social Sciences (SPSS) version 20 (IBM Corp., Armonk, NY, USA). Results: We found elevated HbA1c levels (5.67±1.1%) in non-diabetic iron-deficient anaemia individuals, and elevation was more in women of reproductive age group (30.8%). There was a statistically significant Spearman negative correlation between hemoglobin and HbA1C levels. Also, 16 patients had hyponatremia with a mean haemoglobin (Hb) of 4.8 g/dL and one patient had hyperkalemia with a mean Hb of 3.2 g/dL which was statistically non-significant. Conclusion: In this study haemoglobin and HbA1c had a statistically significant positive correlation with serum sodium and a negative correlation with serum potassium in moderate to severely iron-deficient anaemic patients, especially females of the reproductive age group.

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“…In contrast to patients without anemia, people with anemia had lower salt and potassium levels, according to Mansoor F et al 2021 [5] . Increased Na + /K + ATPase activity in anaemic patients compensates for the normal function of this enzyme in the cell and its method for adaptation to patients with low oxygen levels [6,7] . Changes in membrane-bound enzymes have a direct impact on the levels of Na + and K + in the serum.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of haemoglobin and serum electrolyte in the case of glycosuria

Kathiriya,

Patel,

Patel

et al. 2023

Int. J. Appl. Res.

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Background: Electrolyte imbalance range in severity of its kind. It primarily affect diabetics because of osmotic fluid changes brought on by hyperglycemia. Numerous writers have discussed it in relation to diabetic and anemic patients, but there hasn't been much discussion of glycosuria, a disease brought on by the proximal tubules of the glomerulus failing to absorb enough sugar or glucose. Aim: To determine the relationship between electrolyte (Sodium & Potassium), haemoglobin, and urine glucose/glycosuria concentration. Materials and Method: A total of 170 patients (90 men and 80 women) blood & urine samples were evaluated in the study, which was carried out at Saraswati Multispeciality Hospital & Trauma Centre, Bopal, Ahmedabad between January 2023 and March 2023. The samples were examined using conventional automatic instruments. Result: The concentration of electrolytes (Sodium and Potassium) had shown an increase with the increase in age from 0 to 30 in the age group of 0 to 5 and 5 to 30 in case of male & female both respectively but the pattern was observed variable after the age of 30 in both the cases (male & female) in the age group of 30 to 50 and above 50. Our observation shows that, in the case of glycosuria, there were no obvious electrolyte imbalances (sodium and potassium) at normal haemoglobin level. Conclusion:We saw an age-dependent pattern of electrolyte imbalance, but none of them fell within the reference range of hyponatremia, hypernatremia, hypokalemia, and hyperkalemia.

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Evaluation of serum electrolyte levels in iron deficiency anemia patients.

Cited by 5 publications

References 11 publications

Role of serum sodium on heart, anemia, and diabetes patients

Role of serum sodium on heart, anemia, and diabetes patients

Assessment of Serum Electrolytes and Glycated Hemoglobin Level in Non-diabetic Iron-Deficient Anaemic Patients

Evaluation of haemoglobin and serum electrolyte in the case of glycosuria

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