Evaluation of Serum IgA Antibodies to Epstein-Barr Virus Early and Viral Capsid Antigens in Nasopharyngeal Carcinoma

Rahman, Sukri; Kurniawan, Heru; Budiman, Bestari Jaka; Yerizel, Eti; Bachtiar, Hafni

doi:10.18502/keg.v1i2.4452

Cited by 2 publications

(9 citation statements)

References 17 publications

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“…Most NPC patients were <60 years old (93.1%) and most of them were male (58.6%). In line with this study, Rahman et al reported that NPC patients in Padang were found at an average age of 44.6 years and mostly occurred in men (60%) [13]. The results are in line with research in Denpasar Bali that the incidence of NPC is mostly found in patients aged more than 50 years [16].…”

Section: Discussionsupporting

confidence: 90%

“…Serological results obtained Ig A anti-EA EBV levels in NPC Nias patients with a mean of 246.22 ± 320.05 U/mL. This result is higher than the level of IgA anti-EA EBV in NPC patients in the hospital Hasan Sadikin of 52.18 ± 8.93 U/mL and in NPC patients at Dr. M. Djamil Padang of 114.705 ± 136.524 U/mL [13], [19].…”

Section: Discussionmentioning

confidence: 75%

“…Detecting IgA antibodies against EA antigen and EBV virus in NPC patients can be a tool for early detection in NPC patients to facilitate the management of NPC patients and prevent the severity and increase the success of therapy. The previous studies reported that IgA anti-EA EBV was significantly different between NPCs and controls [13], but other studies reported different results, where IgA anti-EA EBV was significantly different between NPCs and controls [14]. In addition, EBV anti-EA IgA was reported to differ by ethnicity [15].…”

Section: Introductionmentioning

confidence: 93%

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The Serological Examination of Immunoglobulin A Anti-Early Antigen of Epstein–Barr Virus (Anti-EA EBV IgA) in the Nias Tribe Nasopharyngeal Cancer Patients

Ginting

Farhat²,

Sari³

2022

Open Access Maced J Med Sci

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BACKGROUND: Nasopharyngeal cancer (NPC) is a health problem associated with malignancies of the ear, nose, and throat. The main pathogenesis of NPC is Epstein–Barr virus (EBV) infection. The signs and symptoms of NPC are non-specific, causing the occurrence of delay in diagnosis leading to treatment failure. The early detection based on the NPC profile using immunoglobulin A (IgA) antibodies against the early antigen (EA) can be done, but many factors affect anti-EA EBV IgA levels, one of which is ethnicity. AIM: This study aimed to compare levels of anti-EA EBV IgA in NPC patients and non-NPC in the Nias tribe. MATERIALS AND METHODS: This study was cross-sectional involving 29 NPC patients and 29 non-NPC in the Nias tribe. The subjects of the study were blood tests to measure the levels of anti-EA EBV IgA by a serological test. Data were analyzed by Chi-square test. RESULTS: The results showed that the mean value of anti-EA EBV IgA levels is 246.22 ± 320.05 U/mL and the proportion of positive serology tests is 55.2% in NPC patients. The mean value of anti-EA EBV IgA levels is 51.79 ± 1.55 U/mL and the proportion of positive serology tests is 10.3% in non-NPC. The comparison of mean anti-EA EBV IgA between NPC patients and non-NPC was significant (p < 0.001). The comparison of positive and negative serology tests of anti-EA EBV IgA between NPC patients and non-NPC was significant (p < 0.05). CONCLUSION: The serology tests of anti-EA EBV IgA play a role in differentiating NPC patients from non-NPC, so it can be useful as a screening tool for NPC in the Nias tribe.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 93%

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The Serological Examination of Immunoglobulin A Anti-Early Antigen of Epstein–Barr Virus (Anti-EA EBV IgA) in the Nias Tribe Nasopharyngeal Cancer Patients

Ginting

Farhat²,

Sari³

2022

Open Access Maced J Med Sci

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“…While in West Sumatra, based on data collected at Dr.M. Djamil also reported that NPC is the most common malignancy in the head and neck area [4].…”

Section: Introductionmentioning

confidence: 99%

“…About 90% of the world's population has been infected with EBV, but only a small percentage of the EBV-infected population has NPC [9,13]. This is due to many factors that can cause EBV reactivation which is triggered by genetic, carcinogenic and environmental factors [4,8]. This study aimed to know the correlation between EBV (EBNA-1) DNA with NFC incidence in Minangkabau Ethnicity.…”

Section: Introductionmentioning

confidence: 99%

Corelation Between Epstein Barr Virus Epstein Barr Nuclear Antigen 1 DNA with Nasopharyngeal Carcinoma in Minangkabau Ethnic

Ambriani¹,

Rahman²,

Hafiz³

et al. 2021

Advances in Health Sciences Research

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Nasopharyngeal carcinoma (NFC) is a malignancy that come from the nasopharyngeal epithelial cell which is that distribution has been affected by geographic and ethnicity. NFC is caused by multifactorial causes, one of the is Epstein Barr Nuclear Antigen-1 (EBNA-1). EBNA-1 affects some of the signalling pathways, including cell proliferation, invasion, survival, and DNA Repair. This study aimed to know the correlation between EBV (EBNA-1) DNA with NFC incidence in Minangkabau Ethnicity. This study is analytic observational with a cross-sectional comparative study. Twenty-two plasmas of the NFC patients with Minangkabau ethnicity compared with 22 plasma of NPC patients with non-Minangkabau ethnicity as control, which matched their sex and age (±3 years). EBNA-1 level expression was checked with quantitative real-time PCR (qPCR) methods to check the DNA targeting EBNA-1 from the EBV genome. The data was then analyzed with Saphiro Wilk for normality and continued with the LG10 transformation test. They are then finalized with Mann-Whitney for the two groups. The average expression level of the EBNA-1 in NFC patients is higher than the control's plasma in Minangkabau ethnicity but not statistically significant.

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Evaluation of Serum IgA Antibodies to Epstein-Barr Virus Early and Viral Capsid Antigens in Nasopharyngeal Carcinoma

Abstract: .

Cited by 2 publications

References 17 publications

The Serological Examination of Immunoglobulin A Anti-Early Antigen of Epstein–Barr Virus (Anti-EA EBV IgA) in the Nias Tribe Nasopharyngeal Cancer Patients

The Serological Examination of Immunoglobulin A Anti-Early Antigen of Epstein–Barr Virus (Anti-EA EBV IgA) in the Nias Tribe Nasopharyngeal Cancer Patients

Corelation Between Epstein Barr Virus Epstein Barr Nuclear Antigen 1 DNA with Nasopharyngeal Carcinoma in Minangkabau Ethnic

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