AbstrakLatar belakang: Karsinoma nasofaring adalah tumor ganas epitel nasofaring yang sampai saat ini penyebabnya belum diketahui, infeksi virus Epstein Barr dilaporkan sebagai faktor dominan terjadinya karsinoma nasofaring tetapi faktor non viral juga berperan untuk timbulnya keganasan nasofaring. Tujuan: Untuk mengetahui faktor non viral yang dapat meningkatkan kejadian karsinoma nasofaring sehingga dapat mencegah dan menghindari faktor-faktor non viral tersebut. Tinjauan Pustaka: Karsinoma nasofaring merupakan tumor ganas epitel nasofaring yang penyebabnya berhubungan dengan faktor viral dan non viral diantaranya asap rokok, ikan asin, formaldehid, genetik, asap kayu bakar , debu kayu, infeksi kronik telinga hidung tenggorok, alkohol dan obat tradisional. Kesimpulan: Pembuktian secara klinis dan ilmiah terhadap faktor non viral sebagai penyebab timbulnya karsinoma nasofaring masih belum dapat dijelaskan secara pasti. Faktor non viral merupakan salah satu faktor risiko yang dapat meningkatkan angka kejadian timbulnya keganasan nasofaring Kata kunci: karsinoma nasofaring, faktor risiko, non viral AbstractBackground: Nasopharyngeal carcinoma is a malignant epithelial nasopharyngeal tumor that until now the cause still unknown, Epstein barr virus infection had reported as predominant occurance of nasopharyngeal carcinoma but non viral factors may also contribute to the onset of the incidence of nasopharyngeal malignancy. Purpose: To find non viral factors that may increase the incidence of nasopharyngel carcinoma in order to prevent and avoid non-viral factors Literature: Nasopharyngeal carcinoma is a malignant tumor that causes nasopharyngeal epithelium associated with viral and non-viral factors such as cigarette smoke, salt fish, formaldehyde, genetic, wood smoke ,wood dust, ear nose throat chronic infections, alcohol, and traditional medicine. Conclusion: Clinically and scientifically proving the non-viral factors as the cause of nasopharyngeal carcinoma can not be explained with certainty. Non-viral factors only as one risk factor that can increase the incidence of the onset of nasopharyngeal carcinoma.

Abstrak Rinosinusitis kronik adalah inflamasi kronik pada mukosa hidung dan sinus paranasal yang sering terjadi, tetapi belum ada data mengenai profil pasien rinosinusitis kronik di RSUP Dr.M.Djamil Padang. Penelitian ini merupakan penelitian deskriptif dengan mengambil data rekam medis THT-KL RSUP Dr.M.Djamil periode 1 Januari -31 Desember 2012 dengan metode total sampling. Terdapat 63 kasus rinosinusitis kronik di poliklinik THT-KL RSUP Dr.M.Djamil Padang periode 1 Januari -31 Desember 2012. Kasus rinosinusitis kronik paling banyak terjadi pada kelompok usia 46 -55 tahun (22,22%) dan banyak terjadi pada perempuan (60,32%). Berdasarkan tanda dan gejala yang ditemukan paling banyak adalah deviasi septum (41,27%). Gejala klinik paling banyak adalah hidung tersumbat (88,89%). Berdasarkan pemeriksaan rinoskopi anterior dan nasoendoskopi ditemukan kelainan pada kavum nasi, konka inferior, konka media, dan sekret. Disimpulkan bahwa rinosinusitis kronik banyak terjadi pada usia dewasa, jenis kelamin perempuan, tanda dan gejala yang ditemukan deviasi septum, gejala berupa hidung tersumbat, serta ditemukan kelainan berdasarkan pemeriksaan rinoskopi anterior dan nasoendoskopi. Kata kunci: rinosinusitis kronik, pemeriksaan rinoskopi anterior, pemeriksaan nasoendoskopi Abstract Chronic rhinosinusitis is a common chronic inflammation of the nose and paranasal sinuses mucosa, but there is no data about profile of chronic rhinosinusitis patients at ENT clinic Dr.M.Djamil general hospital Padang. This research uses descriptive method by taking the data from the medical records at ENT clinic of Dr.M.Djamil general hospital during 1 January -31 December 2012 with the method is total sampling. There are 63 chronic rhinosinusitis cases at ENT clinic Dr.M.Djamil Padang general hospital during 1 January -31 December 2012. Most cases of chronic rhinosinusitis occurred in the age group 46 -55 years old (22.22%) and higher in female (60.32%). The most sign and symptom finding is septal deviation (41.27%). The most clinical symptom is nasal obstruction (88.89%). From anterior rhinoscopy and nasoendoscopy examination, there are founded abnormalility of nasal cavity, inferior turbinate, middle turbinate, and nasal discharge. The conclusion is chronic rhinosinusitis often happened at adult ages, female, septal deviation as the most sign and symptom finding, nasal obstruction as the clinical symptom, and abnormal findings from anterior rhinoscopy and nasal endoscopy examination.

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AbstrakCapillary haemangioma is a benign, rapidly growing lesion of the skin and mucous membranes. It may rarely present as a mass of considerable size and thus entirely fill the nasal cavity. Its etiology remains obscure. Capillary haemangioma usually involves the gingiva, lips, tongue, and buccal mucosa. However, the nasal cavity is a rare location for this lesion. The most common symptoms are unilateral epistaxis and nasal obstruction. The treatment of choice is surgery to remove the tumour even for large lesion. A case of capillary haemangioma at anterior nasal septal in 6 years old girl had been treated with extirpation. AbstractHaemangioma kapiler merupakan suatu lesi jinak pada kulit dan mukosa dengan pertumbuhan yang cepat. Meskipun jarang berukuran besar, namun dapat memenuhi seluruh kavum nasi. Etiologinya sampai sekarang masih belum jelas. Haemangioma kapiler sering terdapat pada ginggiva, bibir, lidah dan mukosa bukal. Kavum nasi merupakan lokasi yang jarang terdapatnya haemangioma kapiler. Gejala yang paling sering adalah unilateral epistaksis dan sumbatan hidung. Pembedahan untuk mengangkat tumor ini merupakan terapi pilihan meskipun berukuran besar. Suatu kasus haemangioma kapiler septum anterior pada anak perempuan berumur 6 tahun telah dilakukan ekstirpasi sebagai terapi.

Table of contentsA1 Hope and despair in the current treatment of nasopharyngeal cancerIB TanI1 NPC international incidence and risk factorsEllen T ChangI2 Familial nasopharyngeal carcinoma and the use of biomarkersChien-Jen Chen, Wan-Lun Hsu, Yin-Chu ChienI3 Genetic susceptibility risk factors for sporadic and familial NPC: recent findingsAllan HildesheimI5 Genetic and environmental risk factors for nasopharyngeal cancer in Southeast AsiaJames D McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena DeviI6 Characterization of the NPC methylome identifies aberrant epigenetic disruption of key signaling pathways and EBV-induced gene methylationLi L, Zhang Y, Fan Y, Sun K, Du Z, Sun H, Chan AT, Tsao SW, Zeng YX, Tao QI7 Tumor exosomes and translational research in NPCPierre Busson, Claire Lhuillier, Olivier Morales, Dhafer Mrizak, Aurore Gelin, Nikiforos Kapetanakis, Nadira DelhemI8 Host manipulations of the Epstein-Barr virus EBNA1 proteinSheila Mansouri, Jennifer Cao, Anup Vaidya, and Lori FrappierI9 Somatic genetic changes in EBV-associated nasopharyngeal carcinomaLo Kwok WaiI10 Preliminary screening results for nasopharyngeal carcinoma with ELISA-based EBV antibodies in Southern ChinaSui-Hong Chen, Jin-lin Du, Ming-Fang Ji, Qi-Hong Huang, Qing Liu, Su-Mei CaoI11 EBV array platform to screen for EBV antibodies associated with NPC and other EBV-associated disordersDenise L. Doolan, Anna Coghill, Jason Mulvenna, Carla Proietti, Lea Lekieffre, Jeffrey Bethony, and Allan HildesheimI12 The nasopharyngeal carcinoma awareness program in IndonesiaRenske Fles, Sagung Rai Indrasari, Camelia Herdini, Santi Martini, Atoillah Isfandiari, Achmad Rhomdoni, Marlinda Adham, Ika Mayangsari, Erik van Werkhoven, Maarten Wildeman, Bambang Hariwiyanto, Bambang Hermani, Widodo Ario Kentjono, Sofia Mubarika Haryana, Marjanka Schmidt, IB TanI13 Current advances and future direction in nasopharyngeal cancer managementBrian O’SullivanI14 Management of juvenile nasopharyngeal cancerEnis OzyarI15 Global pattern of nasopharyngeal cancer: correlation of outcome with access to radiotherapyAnne WM LeeI16 The predictive/prognostic biomarker for nasopharyngeal carcinomaMu-Sheng ZengI17 Effect of HLA and KIR polymorphism on NPC riskXiaojiang Gao, Minzhong Tang, Pat Martin, Yi Zeng, Mary CarringtonI18 Exploring the Association between Potentially Neutralizing Antibodies against EBV Infection and Nasopharyngeal CarcinomaAnna E Coghill, Wei Bu, Hanh Nguyen, Wan-Lun Hsu, Kelly J Yu, Pei-Jen Lou, Cheng-Ping Wang, Chien-Jen Chen, Allan Hildesheim, Jeffrey I CohenI19 Advances in MR imaging in NPCAnn D KingO1 Epstein-Barr virus seromarkers and risk of nasopharyngeal carcinoma: the gene-environment interaction study on nasopharyngeal carcinoma in TaiwanYin-Chu Chien, Wan-Lun Hsu, Kelly J Yu, Tseng-Cheng Chen, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Laio, Yen-Liang Chang, Cheng-Ping Wang, Chun-Hun Hua, Ming-Shiang Wu, Chu-Hsing Kate Hsiao, Jehn-Chuan ...