Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties

Doddola, Sujatha; Pasupulati, Haritha; Koganti, Bharathi; Prasad, K. V. S. R. G.

doi:10.1007/s11418-008-0235-2

Cited by 64 publications

(36 citation statements)

References 28 publications

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“…There was no any behaviourl changes in rats except excessive urination. [54] l) Immunomodulatory activity…”

Section: D) Antidiabetic Propertymentioning

confidence: 99%

A Review on Neutraceutical Value of Sesbania Grandiflora (Agati)

Janani¹

2017

WJPR

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Sesbania grandiflora, commonly known as Agati or Hummingbird tree is used as folk medicine for various infection and diseases. The whole plant is loaded with pharmacological activities and used for treating anemia, microbial infections, tuberculosis etc. The antioxidant property of Agati is due to the presence of phytochemical constituents making it a potent anticancer and hepatoprotective agent. The present review focusses on the medicinal properties of Sesbania grandiflora.

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“…There was no any behaviourl changes in rats except excessive urination. [54] l) Immunomodulatory activity…”

Section: D) Antidiabetic Propertymentioning

confidence: 99%

A Review on Neutraceutical Value of Sesbania Grandiflora (Agati)

Janani¹

2017

WJPR

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“…It has been reported that the oral administration of leaves extract even at the maximum single dose of 2000 mg/kg body weight was found to be safe, since no mortality 41 .…”

Section: Table 9: Effect Of Sesbania Grandiflora Extract On the Activmentioning

confidence: 99%

“…Sesbania grandiflora possess hepatoprotective 8 , anticancer activity 9 . For congenital bronchitis or cold in babies, leaf juice mixed with honey is often recommended 10 (Nadkarni, 1982).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

IJPSR

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Diabetes mellitus is a metabolic syndrome involving severe insulin dysfunction in conjugation with gross abnormalities in glucose homeostasis and lipid metabolism, which has been affecting several millions of population all over the world. Despite the introduction of hypoglycemic agents from natural as well as synthetic sources, diabetes and its secondary complications continue to be a major health problem for the medical fraternity. Sesbania grandiflora L. Pers. is an Indian medicinal plant which belongs to family Leguminosae possesses a wide array of beneficial and pharmacological properties. In the present study an attempt has been made to evaluate the antidiabetic and antioxidant nature of Sesbania grandiflora leaves. Diabetes was induced by single intraperitoneal injection of streptozotocin (45mg/Kg b.wt). Diabetic rats orally treated with leaves extract ( 300 mg/kg b.w/day) for 30 days resulted in significant (p<0.05) decrease in the levels of blood glucose, glycosylated hemoglobin, blood urea, serum uric acid, serum creatinine and diminished activities of pathophysiological enzymes such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP). The levels of glycogen content and the activities of glycogen metabolizing enzymes were normalized in diabetic rats treated with leaves extract. The elevated oxidative stress marker and diminished antioxidant status were normalized indicating the antioxidant potential of leaves extract. The results of the present study indicate that the leaves extract possess both antidiabetic and antioxidant potent which could be attributed to the presence of pharmacologically active ingredients such as vitamins, flavonoids, saponins, tannins, diterpenes, triterpenoids, glycosides and phenols in the leaves.

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“…S. grandiflora leaves used for the treatment of nervous system diseases such as anxiety and convulsion (Kasture et al 2002). Besides, it has antifertility, anti-inflammatory, analgesic, antipyretic, antiurolithiatic, anticancer, antioxidant, antibacterial, and cytoprotective activity (Shrivastav and Janin 1993;Tamboli 1996Tamboli , 2000Doddola et al 2008;Sreelatha et al 2011;Kumaravel et al 2011;Zarena et al 2014). Our earlier experiments reported some protective effects of S.grandiflora on cigarette smokeexposed rats (Ramesh et al 2007(Ramesh et al , 2010(Ramesh et al , 2014.…”

Section: Introductionmentioning

confidence: 99%

Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

et al. 2015

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Cigarette smoking has been associated with high risk of neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis, etc., The present study was designed to evaluate the restorative effects of Sesbania grandiflora (S. grandiflora) on oxidative damage induced by cigarette smoke exposure in the brain of rats. Adult male Wistar-Kyoto rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with S. grandiflora aqueous suspension (SGAS, 1000 mg/kg body weight per day by oral gavage) for a period of 3 weeks. The levels of protein carbonyl, nitric oxide, and activities of cytochrome P450, NADPH oxidase and xanthine oxidase were significantly increased, whereas the levels of total thiol, protein thiol, non-protein thiol, nucleic acids, tissue protein and the activities of Na(+)/K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase were significantly diminished in the brain of rats exposed to cigarette smoke as compared with control rats. Also cigarette smoke exposure resulted in a significant alteration in brain total lipid, total cholesterol, triglycerides and phospholipids content. Treatment of SGAS is regressed these alterations induced by cigarette smoke. The results of our study suggest that S. grandiflora restores the brain from cigarette smoke induced oxidative damage. S. grandiflora could have rendered protection to the brain by stabilizing their cell membranes and prevented the protein oxidation, probably through its free radical scavenging and anti-peroxidative effect.

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Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties

Cited by 64 publications

References 28 publications

A Review on Neutraceutical Value of Sesbania Grandiflora (Agati)

A Review on Neutraceutical Value of Sesbania Grandiflora (Agati)

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Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

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