Evaluation of some antioxidants and malondialdehyde (MDA) in iraqi women infected with breast cancer and toxoplasmosis in Al-Diwaniyah and Al-Najaf provinces

ameer, Taghreed H. Abd_al; Al-Mayali, Hadi M. Hamza; Kadhem, Wejdan M.

doi:10.1016/j.matpr.2021.07.236

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…SOD, an antioxidant enzyme, plays a fundamental and essential role in the resistance of biological systems to free radical attack. When free radicals attack polyunsaturated fatty acids lipid peroxidation occurs, producing low molecular weight MDA [38] . Therefore, SOD and MDA levels can reflect intracellular free radical levels.…”

Section: Discussionmentioning

confidence: 99%

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H ₂O ₂-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways

Chen,

Xie,

Wen

et al. 2024

Food Science and Human Wellness

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Intestinal oxidation-reduction balance is essential to protect host health. Research on the underlying mechanisms of oxidation homeostasis can provide conditions to the treatment or protection of intestinal oxidative stress. Therefore, the mechanism of polysaccharide (MBP) with alkali-extracted from mung bean skin in alleviating oxidative damage induced by H 2 O 2 -induced in Intestinal epithelial cells (IEC)-6 cells was explored. Results indicated that MBP effectively mitigated the H 2 O 2 -induced decrease in IEC-6 cell viability, restored superoxide dismutase (SOD) activity, lowered malondialdehyde (MDA) content, and decreased reactive oxygen species (ROS) level. Western blotting showed that MBP may mitigate oxidative damage through NF-κB, MAPK and Nrf2 signaling pathway, and RNA sequencing (RNA-seq) analysis confirmed that MBP can protect cells by regulating MAPK and NF-κB signaling pathways. Moreover, the results of the inhibitor experiment also support the above hypothesis. These results verified that MBP has the capacity to mitigate oxidative damage induced by H 2 O 2 in IEC-6 cells through MAPK and NF-κB signaling pathway. The study showed that MBP can assist preventing intestinal diseases relating to oxidative stress, which could facilitate the development of functional foods.

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Section: Discussionmentioning

confidence: 99%

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H ₂O ₂-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways

Chen,

Xie,

Wen

et al. 2024

Food Science and Human Wellness

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show abstract

“…Then, the mixture was heated at 95 °C for 60 min. After heating, a red pigment was produced, and that was extracted with 5 mL of the n -butanol–pyridine mixture and centrifuged at 5000 rpm for 10 min at room temperature . The absorbance of the supernatant was noted at 535 nm.…”

Section: Materials and Methodsmentioning

confidence: 99%

Facile and Green Fabrication of Highly Competent Surface-Modified Chlorogenic Acid Silver Nanoparticles: Characterization and Antioxidant and Cancer Chemopreventive Potential

et al. 2022

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The eco-friendly, cost-effective, and green fabrication of nanoparticles is considered a promising area of nanotechnology. Here, we report on the green synthesis and characterization of bovine serum albumin (BSA)-decorated chlorogenic acid silver nanoparticles (AgNPs-CGA-BSA) and the studies undertaken to verify their plausible antioxidant and antineoplastic effects. High-resolution transmission electron microscopy (HR-TEM), dynamic light scattering, X-ray diffraction, and Fourier transform infrared analyses depict an average mean particle size of ∼96 nm, spherical morphology, and nanocrystalline structure of AgNPs-CGA-BSA. DPPH scavenging and inhibition of lipid peroxidation signify the noticeable in vitro antioxidant potential of the nanoparticles. The in vitro experimental results demonstrate that AgNPs-CGA-BSA shows significant cytotoxicity to Dalton’s lymphoma ascites (DLA) cells and generates an enhanced intracellular reactive oxygen species and oxidized glutathione (GSSG) and reduced glutathione (GSH) in DLA cells. Furthermore, mechanism investigation divulges the pivotal role of the downregulated expression of superoxide dismutase (SOD) and catalase (CAT), and these ultimately lead to apoptotic chromatin condensation in AgNPs-CGA-BSA-treated DLA cells. In addition, in vivo experiments reveal an excellent decrease in tumor cell count, an increase in serum GSH and CAT, SOD, and glutathione peroxidase activities, and a decrease in the malondialdehyde (MDA) level in DLA-bearing mice after AgNPs-CGA-BSA treatment. These findings suggest that the newly synthesized biogenic green silver nanoparticles have remarkable in vitro antioxidant and antineoplastic efficacy that triggers cytotoxicity, oxidative stress, and chromatin condensation in DLA cells and in vivo anticancer efficacy that enhances the host antioxidant status, and these might open a new path in T-cell lymphoma therapy.

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Assessment of Tissue Oxidative Stress, Antioxidant Parameters, and Zinc and Copper Levels in Patients with Breast Cancer

Barartabar

Moini

Abbasalipourkabir

et al. 2022

Biol Trace Elem Res

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Evaluation of some antioxidants and malondialdehyde (MDA) in iraqi women infected with breast cancer and toxoplasmosis in Al-Diwaniyah and Al-Najaf provinces

Cited by 3 publications

References 12 publications

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H ₂O ₂-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H ₂O ₂-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways

Facile and Green Fabrication of Highly Competent Surface-Modified Chlorogenic Acid Silver Nanoparticles: Characterization and Antioxidant and Cancer Chemopreventive Potential

Assessment of Tissue Oxidative Stress, Antioxidant Parameters, and Zinc and Copper Levels in Patients with Breast Cancer

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Evaluation of some antioxidants and malondialdehyde (MDA) in iraqi women infected with breast cancer and toxoplasmosis in Al-Diwaniyah and Al-Najaf provinces

Cited by 3 publications

References 12 publications

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H 2O 2-induced IEC-6 cells: the role of NF-&kappa;B and MAPK signaling pathways

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H 2O 2-induced IEC-6 cells: the role of NF-&kappa;B and MAPK signaling pathways

Facile and Green Fabrication of Highly Competent Surface-Modified Chlorogenic Acid Silver Nanoparticles: Characterization and Antioxidant and Cancer Chemopreventive Potential

Assessment of Tissue Oxidative Stress, Antioxidant Parameters, and Zinc and Copper Levels in Patients with Breast Cancer

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Alkali-extracted polysaccharides from mung bean skin possess protective effect on H ₂O ₂-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H ₂O ₂-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways