2014
DOI: 10.1016/j.chroma.2014.07.078
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Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography

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Cited by 44 publications
(7 citation statements)
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“…While the original particle size of the new generation shell column was of the order of 2.5 m, columns packed with sub 2m shell particles are now widely commercially available and can give further improvements in performance, if appropriate instrumentation is available 31,32 . This improvement can be seen for the kinetic plots in Fig.…”
Section: Effect Of Particle Size and Column Dimensionsmentioning
confidence: 99%
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“…While the original particle size of the new generation shell column was of the order of 2.5 m, columns packed with sub 2m shell particles are now widely commercially available and can give further improvements in performance, if appropriate instrumentation is available 31,32 . This improvement can be seen for the kinetic plots in Fig.…”
Section: Effect Of Particle Size and Column Dimensionsmentioning
confidence: 99%
“…While the original particle size of the new generation shell column was of the order of 2.5 μm, columns packed with sub 2 μm shell particles are now widely commercially available and can give further improvements in performance, if appropriate instrumentation is available. , This improvement can be seen for the kinetic plots in Figure b where separations requiring around 20 000 plates can be achieved in around 1 min on a 1.6 μm shell column but require significantly longer on the totally porous column of about the same particle size (1.8 μm).…”
Section: Small Particle/shell Particle Columnsmentioning
confidence: 99%
“…But there are still supercially porous silica (SPSi) which consists of a non-porous silica core surrounded by a thin shell of porous silica (typically of 1-2 mm thickness), with overall particle size being $30 mm. 61,62 Such particles are usually used as a stationary phase for chromatography to separate biomolecules. Those with pore diameter of $100Å can be used for separating small molecules and those with 160-200Å pore diameter are available for separating peptides and small proteins.…”
Section: Porous Silica (Psi)mentioning
confidence: 99%
“…A more progressive strategy is using a design of experiment (DoE) approach where multiple parameters can be evaluated simultaneously. DoE approaches are already widely applied in bioanalytical science, emergency toxicology, environmental analytics, food analytics, , metabolomics, pharmaceutical analytics, and water analytics mostly for optimization of the chromatographic separation.…”
mentioning
confidence: 99%