Evaluation of the Acute Effects and Oxidative Stress Responses of Phenicol Antibiotics and Suspended Particles in Daphnia magna

Abstract

Suspended particles (SP) exist widely in various water systems and are able to adsorb other pollutants in water, producing ecotoxic effects on aquatic nontarget species. Until now, however, few studies have focused on the effects of SP on antibiotics. Therefore, the present study investigated the effects of the mixtures of SP and phenicol antibiotics (chloramphenicol [CAP], thiamphenicol [TAP]) on acute toxicity and oxidative stress responses in Daphnia magna. The results indicated that the acute toxicity of phenicol antibiotics in D. magna was increased when combined with SP. Besides, the immobilization of daphnids caused by phenicol drugs in the presence of 10 mg/L of SP was more intense than that with 200 mg/L of SP. Furthermore, the impact of SP with diverse concentrations on the activity of catalase and the level of reduced glutathione in D. magna was different. Notably, almost all CAP + TAP + SP treatments markedly increased malondialdehyde content in D. magna, causing potential cellular oxidative damage in D. magna. In summary, the present study provides insights into the toxic effects of phenicol antibiotic and SP mixtures on aquatic organisms. Environ Toxicol Chem 2021;40:2463–2473. © 2021 SETAC

Antibiotic Pollution of Planktonic Ecosystems: A Review Focused on Community Analysis and the Causal Chain Linking Individual- and Community-Level Responses

“…Luo et al reported that lomefloxacin causes oxidative stress and induces cellular damage in Daphnia . The formation of ROS is a widely accepted mechanism by which antibiotic damage harms membrane lipids, proteins, and nucleic acids, eventually leading to changes in the physicochemical properties of the zooplankton, as well as damage or death. − As the final breakdown product of lipid peroxidation, MDA has been widely used as an indicator of cellular oxidative damage in organisms under antibiotic stress . Zhang et al observed a substantial increase in the level of MDA when D. magna was exposed to chloramphenicol and thiamphenicol.…”