Evaluation of the acute oral toxicity class of tricentric chromium(III) propionate complex in rat

Staniek, Halina; Krejpcio, Zbigniew; Iwanik, Katarzyna

doi:10.1016/j.fct.2009.12.022

Cited by 40 publications

(16 citation statements)

References 33 publications

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“…Staniek et al reported that no death cases were detected and no major abnormalities in animal behavior, body mass gains, and gross organ histology were observed when the rats were given by gavage either a single dose of chromium(III) propionate complex of 2,000 mg/kg body mass for 14 days and LD 50 of chromium propionate is greater than 2,000 mg/kg when administrated orally to rat [14], which were in accordance with the results in the present study.…”

Section: Uptake Of [Cr 2 (Lma) 3 ] In Normal and Alloxan-induced Diabmentioning

confidence: 96%

“…The pro-oxidant nature of chromium picolinate greatly limited its therapeutic applications. In order to reduce the toxicity and improve tissue uptake and efficiency of chromium, the natural ligand with less or non-toxicity is of great interest [12][13][14]. L-malic acid is a natural organic acid, which is non-toxic to humans and the environment, and has been reported to possess enhancement of mitochondrial respiration [15], natural antioxidant [16], and enhancement of carboxylate metabolism [17], etc.…”

Section: Introductionmentioning

confidence: 99%

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Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats

et al. 2010

Biol Trace Elem Res

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The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis, thermodynamic analysis, and spectroscopy studies, the molecular formula of [Cr2(LMA)3] was inferred as Cr2(C4H4O5)3·5H2O. Daily treatment with 2.85-17.10 mg/kg body mass of [Cr2(LMA)3] in alloxan-induced diabetic rats for 2 weeks indicated that low-molecular-weight organic chromium complex [Cr2(LMA)3] had better bioavailability and more beneficial influences on the improvement of controlling blood glucose, serum lipid, and liver glycogen levels compared with CrCl3·6H2O. [Cr2(LMA)3] did not cause oxidative DNA damage under physiologically relevant conditions. Acute toxicity studies revealed no-measurable toxicity of the [Cr2(LMA)3]. Collectively, these results suggest that [Cr2(LMA)3] may represent a novel, proper chromium supplement with potential therapeutic value to control blood glucose and serum lipid in diabetes.

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Section: Uptake Of [Cr 2 (Lma) 3 ] In Normal and Alloxan-induced Diabmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats

et al. 2010

Biol Trace Elem Res

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“…As has been reported previously [11], the analysis of the toxicity is often a first step in the study of biological properties of the compounds. The oral acute toxic class method (ATC method) was developed as an alternative to replace the oral LD 50 test.…”

Section: Resultsmentioning

confidence: 99%

“…The safety of Cr(III) compounds used for dietary supplements has been a matter of considerable debate over last decades. The discussion about the toxic effects produced by CrPic have been reviewed recently [11] and will not be repeated in this article. Because there is widespread human exposure to CrPic in dietary supplements, recently Stout et al [12] conducted toxicity and carcinogenicity studies of this compound (in the monohydrate form) in male and female F344/N rats and B6C3F1 mice exposed in feed to concentrations of 0, 2,000, 10,000, or 50,000 ppm for 2 years.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Acute Oral Toxicity Class of Trinuclear Chromium(III) Glycinate Complex in Rat

Staniek

Krejpcio

Iwanik

et al. 2011

Biol Trace Elem Res

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Chromium(III) is considered as an essential element playing a role in carbohydrate and lipid metabolism, and various chemical forms of this element are widely used in dietary supplements. A new trinuclear chromium(III) glycinate complex [Cr3O(NH2CH2CO2)6(H2O)3]+NO3− (CrGly), an analogue of Cr3 (trinuclear Cr(III) propionate complex) has been synthesized as a potential source of supplementary Cr. In this study, we evaluated the acute toxicity class of CrGly in Wistar rats applying the OECD 423 procedure. Male and female Wistar rats (n = 12, 6 ♀ and 6 ♂) were given by gavage either a single dose of CrGly 2,000 mg/kg body mass (equals to 300 mg Cr(III)/kg body mass; in aqueous solution) or equivalent volumes of distilled water and fed ad libitum commercial Labofeed B diet, and observed carefully for 14 days, then sacrificed to collect blood and internal organs for biochemical and histologic examination. No death cases were detected. No abnormalities in animal behavior, body mass gains, gross organ histology, or blood morphology and biochemistry were observed. The results demonstrate that LD50 of CrGly is greater than 2,000 mg/kg when administrated orally to rat; thus, this compound appears to belong to the fifth category in the GHS system or the fourth class (“unclassified”) in the EU classification system.

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“…The Cr(III) nutritional supplements used in this work were Cr(III) picolinate, [Cr(pic) 3 ]·H 2 O (pic = 2-pyridinecarboxylato()) (A), the most popular Cr(III) nutritional supplement and the second largest-selling metal supplement after calcium supplements in the United States [20] (Fig. 1) [21]. …”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometry Analysis of Chromium-Binding Low-Molecular-Weight Serum Fractions

Safitri

Levina

Lay

2017

J. Pure App. Chem. Res.

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Evaluation of the acute oral toxicity class of tricentric chromium(III) propionate complex in rat

Cited by 40 publications

References 33 publications

Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats

Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats

Evaluation of the Acute Oral Toxicity Class of Trinuclear Chromium(III) Glycinate Complex in Rat

Mass Spectrometry Analysis of Chromium-Binding Low-Molecular-Weight Serum Fractions

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