Evaluation of the anthelmintic efficacy of an ivermectin controlled-release capsule in lambs under field conditions in Europe

Rehbein, S; Corba, J; Pitt, Simon R.; Várady, Marián; Langholff, Wayne

doi:10.1016/s0921-4488(99)00018-8

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…These studies were undertaken with the aim of investigating the effects of the ivermectin CRC on the multispecies lungworm infection in sheep. The results of these studies confirm the excellent therapeutic efficacy of the ivermectin CRC against the lungworms D. filaria and P. rufescens as found previously in dose confirmation and field studies (Rehbein et al, 1998, 1999). Over the whole delivering period of about 100 days, treatment with the ivermectin CRC effectively reduced the numbers of the lung parenchyma dwelling protostrongylid nematodes C. ocreatus , N. linearis and P. brevispiculum , which are known to be less susceptible to anthelmintics.…”

Section: Discussionsupporting

confidence: 87%

“…The lower contamination of pasture decreases the risk of infecting other animals and enhances the benefits from treatment with an ivermectin CRC. Furthermore, the results of a field study suggest that treatment with an ivermectin CRC protects sheep from establishment of incoming protostrongylid lungworm infections (Rehbein et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…The sustained activity of the ivermectin CRC aids in the control of Lucilia cuprina myiasis (Rugg et al, 1998). Furthermore, treatment with the ivermectin CRC improved weight gain and resulted in lower accumulation of faeces in the breech area of sheep (Gogolewski et al, 1997b,c; Allerton et al, 1998; Rehbein et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Ivermectin Delivered via a Controlled‐Release Capsule against Small Lungworms (Protostrongylidae) in Sheep

Rehbein¹,

Visser²

2002

Journal of Veterinary Medicine, Series B

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To evaluate the efficacy of an ivermectin controlled-release capsule (CRC), which delivers 1.6 mg ivermectin per day intraruminally for 100 days to sheep weighing 40-80 kg (IVOMEC Maximizer CR Capsule for adult sheep, Merial), against small lungworms two studies with 48 naturally infected adult female Merino Landrace sheep were conducted. The sheep were allocated by restricted randomization based on bodyweight to untreated controls or received an ivermectin CRC. Eight sheep per group were necropsied 35, 70 or 105 days post-treatment. Lungworms were recovered by dissection or peptic digestion of the lungs. Baermann/Wetzel technique was used for faecal lungworm larval counts at weekly intervals. The efficacy of treatment was 100% against Dictyocaulus filaria and Protostrongylus rufescens (P < 0.05) at each necropsy day. The efficacy against Protostrongylus brevispiculum, Cystocaulus ocreatus and Neostrongylus linearis increased from 35 to 105 days after administration of the CRC and was found to be 100% (P < 0.01), 96.6% (P < 0.01) or 99% (P < 0.01), respectively, at 105 days post-treatment. The reductions of Muellerius capillaris counts varied and were 96.2% (P < 0.05) at 70 days post-treatment and 44.6% (P > 0.1) at 105 days post-treatment. Faecal lungworm larvae disappeared nearly completely from at least 3 weeks after the ivermectin CRC administration for all protostrongylid species including M. capillaris so that pasture infectivity will be subsequently significantly reduced.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Efficacy of Ivermectin Delivered via a Controlled‐Release Capsule against Small Lungworms (Protostrongylidae) in Sheep

Rehbein¹,

Visser²

2002

Journal of Veterinary Medicine, Series B

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“…Nematode parasitism negatively impacts the production (meat, milk, wool) and reproduction of sheep and has the capability to seriously compromise the health and welfare of the animals. Even subclinical nematode infections cause losses of productivity as demonstrated repeatedly by treatment-induced improved performance e. g., [ 1 – 10 ]. Therefore, a prerequisite for economically sustainable sheep farming and efficient production is the effective control of ovine nematode parasites [ 8 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep

Hamel¹,

Bosco

Rinaldi

et al. 2017

BMC Vet Res

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BackgroundThe anthelmintic efficacy of the 0.5% w/v topical formulation of eprinomectin (EPN), EPRINEX® Pour-on (Merial) when administered at 1 mg/kg body weight was evaluated in sheep in two dose confirmation laboratory studies and one multicenter field study. In addition, the pharmacokinetics of EPN when administered at that dosage to adult sheep was determined.ResultsIn the two dose confirmation studies, which included 10 sheep each, sheep treated with topical EPN had significantly (p < 0.05) fewer of the following nematodes than the untreated sheep with overall reduction of nematode counts by >99%: adult Dictyocaulus filaria, Haemonchus contortus, Teladorsagia circumcincta(pinnata/trifurcata), Trichostrongylus axei, T. colubriformis, T. vitrinus, Cooperia curticei, Nematodirus battus, Strongyloides papillosus, Chabertia ovina and Oesophagostomum venulosum, and inhibited fourth-stage Teladorsagia larvae.A total of 196 sheep harboring naturally acquired gastrointestinal nematode infections were included in the field efficacy study at two sites each in Germany (48 Merino x Ile de France lambs, 52 adult Merino females) and in Italy (adult male and female Bagnolese, Lacaune, Lacaune x Bagnolese, Bagnolese x Sarda sheep; 48 animals per site). Animals were blocked on pre-treatment body weight and within each block, one animal was randomly assigned to the control (untreated) group and three animals were randomly assigned to be treated with topical EPN. Examination of feces 14 days after treatment demonstrated that, relative to the controls, topical EPN-treated sheep had significantly (p < 0.0001) lower strongylid egg counts. Reduction was ≥97% at each site and 98.6% across all sites.Pharmacokinetics of EPN following single treatment with topical EPN were determined in eight ~4.5 year old female Merino cross sheep based on the analysis of plasma samples which were collected from two hours to 21 days following treatment. The main pharmacokinetic parameters were: Cmax 6.20 ± 1.71 ng/mL, AUClast 48.8 ± 19.2 day*ng/mL, Tmax 3.13 ± 2.99 days and T1/2 6.40 ± 2.95 days.No treatment-related health problems or adverse drug events were observed in any study.ConclusionThese studies demonstrated 0.5% w/v EPN administered topically at 1 mg/kg body weight to be highly efficacious against a broad range of ovine gastrointestinal nematodes and D. filaria lungworms and well tolerated by sheep of different ages, breeds, gender and physiological status.

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“…(Ahmed et al, 1983 andTalabi, 2002). More over, improvement of weight gain (Rehbein et al, 1999), improved fertility rate of ewes (Garcia-Perez et al, 2002) and increase milk yield and birth weight of lambs (Fthenakis et al, 2005). The weight gain of lambs is highest in ewes given separate anthelmintic treatment for Fasciola and nematodes than that given one drug for both parasites (Maingi et al, 2002).…”

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confidence: 99%

Some studies on enteric parasites of sheep in Beni-Suef Governorate

Hadid

Lotfy²

2007

Journal of Veterinary Medical Research

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This work was carried out in four selected provinces in Beni-Suef Governorate, Egypt to investigate the possibility of existence of different types of enteric parasites infect 2-5 years old sheep and estimate the rate of improvement in some of its productive parameters post eradication of these parasites in relation to each parasitic infection. The study cleared that gasterointestinal bursated nematodes (Haemonchus spp., Trichostrongylus spp., Ostertagia spp., Nematodirus spp. and Cooperia spp.) and Fasciola are the most common parasites infecting sheep (57.44% & 48.44% respectively), this was followed by Paramphistopmum infection (38.88%), Moniezia spp. (33.11%), different types of Eimeria spp. (29%) and finally Trichuris spp (7%). Fecal culture of positive samples demonstrate presence of five types of nematode larvae include Haemonchus spp. larvae (33.75%), Oestertagia spp. (31.5%), Trichostrongylus (11.75%), Cooperia spp. (14.5%) and Nematodirus spp. (8.5%). Using of ivermectin for treatement of GIN, Nitroxynil for treatment of Fasciola, and oxyclozanide for treatment of Paramphistomum species infection, induce marked decrease in the mean number of different eggs per gram (e.p.g.) of faeces associated with improvement in mean body weight gain (5.71 Kg) and rate of lambing (26.77) after 6 months post treatment. High rate of improvement post treatment was recorded in animals originally free from Fasciolia infection, also and that harboring low e.p.g. than animals of high e.p.g. Finally it was evident that high rate of improvement was cleared in animals less than 4 years old in comparison by that over 4 years old.

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Evaluation of the anthelmintic efficacy of an ivermectin controlled-release capsule in lambs under field conditions in Europe

Cited by 10 publications

References 26 publications

Efficacy of Ivermectin Delivered via a Controlled‐Release Capsule against Small Lungworms (Protostrongylidae) in Sheep

Efficacy of Ivermectin Delivered via a Controlled‐Release Capsule against Small Lungworms (Protostrongylidae) in Sheep

Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep

Some studies on enteric parasites of sheep in Beni-Suef Governorate

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