Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio

Yoshida, Yasukazu; Hayakawa, Mieko; Habuchi, Yoko; Niki, Etsuo

doi:10.1016/j.bbagen.2006.06.007

Cited by 46 publications

(44 citation statements)

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“…In this study, experimental animals were used as an antioxidant evaluation model. In such studies, a vitamin E-depleted diet accelerates lipid peroxidation in vivo, which was observed in this study and also in previously reported studies 6,11) . Thus, this model is suitable for the evaluation of antioxidant mixtures in vivo using biomarkers as measures of lipid peroxidation.…”

Section: 8 2asupporting

confidence: 70%

“…The ratio of cis-trans to trans-trans HODE is a measure of the capacity of hydrogen atom donation at the site of oxidation. This measure, i.e., the (Z,E/E,E) HODE ratio, is practically important for the assessment and evaluation of the in vivo antioxidant capacity of natural and synthetic compounds, foods, and beverages, as well as supplements and their components [6][7][8][9][10] . In the present study, we used tHODE and its stereoisomer ratio to investigate the antioxidative effects of coffee administered in drinking water.…”

Section: Introductionmentioning

confidence: 99%

“…They were divided into 6 groups according to the type of diet: a control diet containing 0.002 wt% a-tocopherol (aT, control); a vitamin E-free (Efree) diet (Funabashi Nojyo, Chiba, Japan); and an E-free diet plus coffee (35 g/L), chlorogenic acid (150 mg/L), caffeic acid (10 mg/L), or caffeine (400 mg/L) ( ). The composition of the E-free diet is summarized in our previous report 6) . The mice were maintained under standardized conditions of light (7:00 AM-7:00 PM), temperature (22 ), and humidity (70%).…”

mentioning

confidence: 99%

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Evaluation of the Antioxidant Effects of Coffee and Its Components Using the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane

Yoshida¹,

Hayakawa²,

Niki³

2008

J. Oleo Sci.

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The association between coffee consumption and its antioxidant effects has not been elucidated in detail. In experimental animals, we used biomarkers to investigate the relationship between coffee consumption and its effects on oxidative stress. We propose a method in which both the free and ester forms of hydroperoxides and ketones as well as the hydroxides of linoleic acid are measured as total hydroxyoctadecadienoic acid (tHODE). Mice were divided into 6 groups: animals in 5 of these groups were fed a vitamin E-depleted diet [VE(-) group], whereas those in the 6 th (control) group were fed a diet containing 0.002 wt% vitamin E [VE(+) group]. Different VE(-) groups were also administered coffee or drinking water that contained a coffee component-chlorogenic acid, caffeic acid, or caffeine-for 1 month. It was clearly demonstrated that the liver levels of tHODE in the VE(-) groups increased compared to the VE(+) group but that coffee consumption reduced these elevated levels to that of the control. Interestingly, the plasma and liver levels of the HODE stereoisomer ratio (Z,E/E,E), which is a measure of antioxidant capacity in vivo, were highest among the groups studied. These data, together with the values for antioxidant levels in vivo, indicate that the efficacy of antioxidants in vivo can be evaluated reasonably well based on the tHODE level and its stereoisomer ratio, and that the antioxidant capacity of coffee is superior to that of its individual components. Key words: antioxidant, tHODE, isoprostanes, coffeeCorrespondence to: Yasukazu Yoshida, Health Technology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka Ikeda, Osaka 563-8577, JAPAN E-mail: yoshida-ya@aist.go.jp Accepted July 31, 200831, (received for review March 31, 2008 Journal of Oleo Science ISSN 1345-8957 print / ISSN 1347-3352 online http://www.jstage.jst.go.jp/browse/jos/ Abbreviations: BSTFA, N,O-bis(trimethylsilyl)trifluoroacetamide; tHODE, total hydroxyoctadecadienoic acid; (Z,E/E,E) HODE ratio, molar ratio of HODE stereoisomer, (9-and 13-(Z,E)-HODE)/(9-and 13-(E,E)-HODE); HPODE, hydroperoxyoctadecadienoic acid; t8-iso-PGF 2a , total 8-iso-prostaglandin F 2a ; PBS, phosphate-buffered saline; aT, a-tocopherol; gT, g -tocopherol

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Section: 8 2asupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Evaluation of the Antioxidant Effects of Coffee and Its Components Using the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane

Yoshida¹,

Hayakawa²,

Niki³

2008

J. Oleo Sci.

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“…Under non-pathological processes, the capability of tissues to synthesize CoQ 10 was reported to decrease with age. It is striking that the isomer ratio of HODE Z, E/E, E significantly correlated with Q 10 H 2 and Q 10 , and that this observation is supported by animal experiments 40 .…”

Section: Tablesupporting

confidence: 65%

Chemistry of Lipid Peroxidation Products and Their Use as Biomarkers in Early Detection of Diseases

et al. 2015

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“…In particular, lipoxin A4 (LXA 4 ) was one of the oxylipins that increased the most upon ARA exposure. This indicates that these mediators may also be produced by brain endothelial cells, and that they may have neuroprotective effects, such as the inhibitory effect of LXA 4 on leukotriene synthesis in cerebral ischemia/reperfusion injury [42], its potential role in regulating the restoration of neural stem cells [43].…”

Section: Fatty Acidmentioning

confidence: 99%

Generation of Bioactive Oxylipins from Exogenously Added Arachidonic, Eicosapentaenoic and Docosahexaenoic Acid in Primary Human Brain Microvessel Endothelial Cells

Aukema

Winter

Ravandi

et al. 2015

Lipids

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The human blood-brain barrier (BBB) is the restrictive barrier between the brain parenchyma and the circulating blood and is formed in part by microvessel endothelial cells. The brain contains significant amounts of arachidonic acid (ARA), and docosahexaenoic acid (DHA), which potentially give rise to the generation of bioactive oxylipins. Oxylipins are oxygenated fatty acid metabolites that are involved in an assortment of biological functions regulating neurological health and disease. Since it is not known which oxylipins are generated by human brain microvessel endothelial cells (HBMECs), they were incubated for up to 30 min in the absence or presence of 0.1-mM ARA, eicosapentaenoic acid (EPA) or DHA bound to albumin (1:1 molar ratio), and the oxylipins generated were examined using high performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS). Of 135 oxylipins screened in the media, 63 were present at >0.1 ng/mL at baseline, and 95 were present after incubation with fatty acid. Oxylipins were rapidly generated and reached maximum levels by 2-5 min. While ARA, EPA and DHA each stimulated the production of oxylipins derived from these fatty acids themselves, ARA also stimulated the production of oxylipins from endogenous 18- and 20-carbon fatty acids, including α-linolenic acid. Oxylipins generated by the lipoxygenase pathway predominated both in resting and stimulated states. Oxylipins formed via the cytochrome P450 pathway were formed primarily from DHA and EPA, but not ARA. These data indicate that HBMECs are capable of generating a plethora of bioactive lipids that have the potential to modulate BBB endothelial cell function.

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Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio

Cited by 46 publications

References 24 publications

Evaluation of the Antioxidant Effects of Coffee and Its Components Using the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane

Evaluation of the Antioxidant Effects of Coffee and Its Components Using the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane

Chemistry of Lipid Peroxidation Products and Their Use as Biomarkers in Early Detection of Diseases

Generation of Bioactive Oxylipins from Exogenously Added Arachidonic, Eicosapentaenoic and Docosahexaenoic Acid in Primary Human Brain Microvessel Endothelial Cells

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