Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats

Abstract

Background. For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p<0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p=0.351, p=0.067). In the curcumin group compared with the HP group, a significant difference was observed for two parameters of fibrosis and angiogenesis (p<0.05). Conclusion. Both curcumin and Hypericum perforatum oil are effective in burn wound healing. Our findings showed a better quality of healing in curcumin-treated rats.

Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor binding domain: A computational/simulation study

“…In this study, the lead molecule is obtained from one of the medicinal plants that have been widely used in Iraqi traditional medicine is Hypericum perforatum , also known as perforate St John's-wort. This plant is a flowering perennial herb that is used for versatile therapeutic attributes, such as anxiety [ 58 ], gastric lesions [ 59 ], depression [ 60 ], wounds [ 61 ], and burns [ 62 ]. In addition to its obvious antioxidant role [ 63 ], it has been suggested to include this herb in treating many other ailments, such as cancer [ 64 ], inflammation-related disorders [ 65 ], and viral diseases [ 4 ].…”

Therapeutic potential of second degree's skin burns by topical dressing of Teucrium ramosissimum that promotes re‐epithelialization

“…1 In the proliferative phase, the development of healthy granulation tissue and reepithelialization, 4 which involves migration, proliferation, and differentiation of epithelial cells from the wound edges to resurface the defect. 19 Key components of regenerative medicine, such as growth factors, autologous cells and stem cells that have a self-renewal capacity, gene therapy and tissue engineering, can be used to address different stages of wound healing. 1 Plants from mother nature have developed a great capacity to synthesize different structures and functions of bioactive compounds (>23,000 terpene structures identified in higher plants), including alcohols, aldehydes, carboxylic acids, hydrocarbons, ethers, ketones, and esters.…”

Burn wound healing effects of the root hydroethanolic extract of Cochlospermum planchonii in mice

“…Wounds can be defined as injuries occurring in living tissues that are usually caused by a cut, blow, burn or other impact, typically one in which the skin is cut or broken. Preheated materials applied directly on the skin are usually used to induce this type of wound (Cai et al, 2014;Said et al, 2019;Seyhan, 2020). The restoration of the disturbed functional status of the skin and disrupted anatomical continuity requires proper wound healing.…”