Evaluation of the In Vivo Biological Effects of Marine Collagen and Hydroxyapatite Composite in a Tibial Bone Defect Model in Rats

Parisi, Júlia Risso; Fernandes, Kelly Rossetti; Cruz, Matheus de Almeida; Avanzi, Ingrid Regina; Santana, Alan de França; Vale, Giovanna Caroline Aparecida do; Andrade, Ana Luiza Dias Leite de; Góes, Cíntia Pereira de; Fortulan, Carlos Alberto; Trichês, Eliandra de Sousa; Granito, Renata Neves; Rennó, Ana Cláudia Muniz

doi:10.1007/s10126-020-09955-6

Cited by 14 publications

(6 citation statements)

References 41 publications

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“…Marine sponges in particular are one of the most promising sources among marine invertebrates for the production of collagen-derived biomaterials [6]. Marine sponge-derived collagen was tested for in vitro and in vivo studies, mainly for bone graft applications [7][8][9][10][11], and intact decellularized sponge 3D structures were used as bioinspired scaffolds for bone regeneration experiments [12]. Despite these several examples of the potential use of sponge collagen in regenerative medicine, there is only partial information on molecular characterisations of sponge-derived collagens [13,14], as well as on the molecular mechanisms involved in its biosynthesis [15,16].…”

Section: Introductionmentioning

confidence: 99%

Potential Biomedical Applications of Collagen Filaments derived from the Marine Demosponges Ircinia oros (Schmidt, 1864) and Sarcotragus foetidus (Schmidt, 1862)

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Potential Biomedical Applications of Collagen Filaments derived from the Marine Demosponges Ircinia oros (Schmidt, 1864) and Sarcotragus foetidus (Schmidt, 1862)

et al. 2021

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“…Then, the collagen can be extracted using acid or enzyme, such as pepsin. [30,155] Scaffolds and composites made of collagen derived from marine resources have been demonstrated to have the potential to stimulate tissue regeneration in vivo, such as bone, [156][157][158] skin, [159] and blood and lymphatic vessels (Figure 5a). [160]…”

Section: Collagen From Byproducts Of Fishing Industriesmentioning

confidence: 99%

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

Putra

Zhou

Zadpoor

2023

Adv Healthcare Materials

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The need for sustainable development has never been more urgent, as the world continues to struggle with environmental challenges, such as climate change, pollution, and dwindling natural resources. The use of renewable and recycled waste materials as a source of raw materials for biomaterials and tissue engineering is a promising avenue for sustainable development. Although tissue engineering has rapidly developed, the challenges associated with fulfilling the increasing demand for bone substitutes and implants remain unresolved, particularly as the global population ages. This review provides an overview of waste materials, such as eggshells, seashells, fish residues, and agricultural biomass, that can be transformed into biomaterials for bone tissue engineering. While the development of recycled metals is in its early stages, we highlight the use of probiotics and renewable polymers to improve the biofunctionalities of bone implants. Despite the advances of additive manufacturing (AM), studies on AM waste‐derived bone‐substitutes are limited. It is foreseeable that AM technologies can provide a more sustainable alternative to manufacturing biomaterials and implants. The preliminary results of eggshell and seashell‐derived calcium phosphate and rice husk ash‐derived silica will likely pave the way for more advanced applications of AM waste‐derived biomaterials for sustainably addressing several unmet clinical applications.This article is protected by copyright. All rights reserved

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“…The proliferation of differentiated osteogenic cells influenced by blue shark skin collagen may be achieved through the activation of the Runx2-dependent FAK/JNK signaling pathway [57]. Some researchers have hypothesized that the osteogenic effect of marine collagen may because of its specific fibril formation [58]. The alkaline phosphatase activity of hMSCs was higher on fibril tilapia collagens than on either nonfibril collagen or conventional dishes [58].…”

Section: Improvement In Osteogenesismentioning

confidence: 99%

“…Some researchers have hypothesized that the osteogenic effect of marine collagen may because of its specific fibril formation [58]. The alkaline phosphatase activity of hMSCs was higher on fibril tilapia collagens than on either nonfibril collagen or conventional dishes [58]. Similarly, Jin et al combined fish collagen, nano-HA, and poly(lactide-co-glycolide) to fabricate a nanofibrous membrane using electrospinning.…”

Section: Improvement In Osteogenesismentioning

confidence: 99%

Applications of marine collagens in bone tissue engineering

Lin¹,

Yu²,

Ying³

et al. 2021

Biomed. Mater.

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For decades, collagen has been among the most widely used biomaterials with several biomedical applications. Recently, researchers have shown a keen interest in collagen obtained from marine sources because of its biocompatibility, biodegradability, ease of extractability, safety, low immunogenicity, and low production costs. A wide variety of marine collagen-based scaffolds have been developed for bone tissue engineering, and these scaffolds display excellent biological effects. This review aims to provide an overview of the biological effects of marine collagen in bone engineering, such as promoting osteogenesis and collagen synthesis, inhibiting inflammation, inducing the differentiation of cartilage, and improving bone mineral density. Marine collagen holds great promise as a biomaterial in bone tissue engineering.

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Evaluation of the In Vivo Biological Effects of Marine Collagen and Hydroxyapatite Composite in a Tibial Bone Defect Model in Rats

Cited by 14 publications

References 41 publications

Potential Biomedical Applications of Collagen Filaments derived from the Marine Demosponges Ircinia oros (Schmidt, 1864) and Sarcotragus foetidus (Schmidt, 1862)

Potential Biomedical Applications of Collagen Filaments derived from the Marine Demosponges Ircinia oros (Schmidt, 1864) and Sarcotragus foetidus (Schmidt, 1862)

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

Applications of marine collagens in bone tissue engineering

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