Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

“…The homogenate was centrifuged at 8609g for 20 min at 4°C, and the supernatant was collected for biochemical analysis. While the right femur was weighed and used for the determination of bone mineral density (BMD) according to Archimedes principle (Lee et al 2004b). …”

Royal Jelly Stimulates Bone Formation: Physiologic and Nutrigenomic Studies with Mice and Cell Lines

“…9) In animal models, oral administration of soy isoflavone and pure genistein restored bone loss caused by ovariectomy in rats and mice. [10][11][12] Similarly, a pomegranate extract containing estrogenic compounds can improve bone properties in ovariectomized mice. 13) In this study, we examined the effects of RJ on bone metabolism.…”

Extraction and purification of formonometin from <i>Trifolium pratense</i> L: Physicochemical properties of its complex with lecithin

“…Since isoflavones, one of the four compounds it contained can be used as a natural replacement of estrogen, it is popular for its function to alleviate climateric symptoms in older women. Formononetin (7-Hydroxy-4′-methoxyisoflavone, C 16 H 12 O 4 , CAS: 485-72-3, MW: 268.3), one of the major substance in Red clover, has become a focus of study due to its various pharmacological and biological activities, such as anti-tumor [3], anti-oxidant [4], anti-bacterial [5], anti-inflammatory [6], anti-atherosclerosis [7], and anti-osteoporosis [8]. Therefore, it is widely used as an additive in the food and pharmaceutical industries.…”