Evaluation of the Relationship Between Serum Sodium Concentration and Mortality Rate in ICU Patients with Traumatic Brain Injury

Kiaei, Babak Ali; Farsani, Darioush Moradi; Ghadimi, Keyvan; Shahali, Mahnaz

doi:10.5812/ans.67845

Cited by 6 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 Hypernatremia is a common finding seen in TBI patients, with some studies reporting a prevalence of 30-40% in some instances. 4,6,21 It has also been found that patients with hypernatremia tend to be associated with more severe form of TBI. 7 Our study showed that 50% of total hypernatremia cases had sustained severe TBI 11 (50) followed by moderate 7 (31.8) and mild 4 (18.2) forms of TBI, but didn't show the statistically significant association.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, if chronic hyponatremia is rapidly corrected, osmotic demyelination occurs, which is potentially fatal. 4 Although multiple excellent studies have been conducted on hyponatremia and hypernatremia in patients with TBI, not many studies have incorporated dysnatremia as a whole and its outcome on the basis of severity, mode of injury, and clinical progress in a single study. [4][5][6][7] In this study, we have assessed the association of hyponatremia and hypernatremia with the severity of traumatic brain injury and its impact on mortality among TBI patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dysnatremia in Traumatic Brain Injury and its Association with Outcome

Bishokarma

Thapa

et al. 2022

Kathmandu Univ. Med. J.

View full text Add to dashboard Cite

Background Traumatic brain injury on its own results in significant mortality and morbidity but it also contributes to complications that manifest as dysnatremia in the majority of cases. Objective The objective of this study is to assess the association of hyponatremia and hypernatremia with the severity of traumatic brain injury and its impact on mortality. Method This is a retrospective, descriptive, and analytic study conducted during a 1-year period from March 2018 to March 2019. The study population was selected from the patients presenting to the emergency department with TBI in the Upendra Devkota Memorial National Institute of Neurological and Allied Sciences, Bansbari, Kathmandu, Nepal. All the patients that fulfilled the inclusion criteria of age were enrolled in the study. Patients with known renal disease due to the higher incidence of electrolyte disbalance were excluded. Association of outcome with hyponatremia and hypernatremia were sought using chi-square, fisher exact test and independent t test using SPSS ver 20. Result Over a period of 1 year, 367 patients with traumatic brain injuries were treated in our hospital. Hyponatremia was seen among 55 patients (14.9%) and hypernatremia was seen among 22 patients (5.99%). The age range of patients included in the study was 16 to 87 with a mean age of 37.96 ± 16.512 years. The male to female ratio was calculated as 3.2:1. Mild, moderate, and severe head injuries were 286 (77.9%), 37 (10.1%), and 44 (12%) respectively. Surgical intervention was performed among 77(21%) individuals. Our series showed an association between the severity of traumatic brain injury and hyponatremia however didn’t show an association between the severity of traumatic brain injury and the development of hypernatremia. Conclusion We concluded that the severity of head injury is associated with severity of hyponatremia but not with severity of hypernatremia. Similarly, a strong association existed between the severity of hypernatremia and outcome of patients. However, such association was not seen with hyponatremia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dysnatremia in Traumatic Brain Injury and its Association with Outcome

Bishokarma

Thapa

et al. 2022

Kathmandu Univ. Med. J.

View full text Add to dashboard Cite

show abstract

“…Some studies have suggested that hyponatremia is a common finding in patients with TBIs,[ 15 16 ] which has not been the case in this study. Another study has shown that sodium concentration has no effect on the prognosis of these patients,[ 17 18 ] but studies have shown that administration of hypertonic saline in patients with changes in cranial pressure can reduce cerebral edema and improve the prognosis while keeping plasma sodium higher. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

The Level of Serum Osmolarity at Admission in Prognosis of Nosocomial Mortality in Patients with Severe Brain Trauma

Ziaei

Galavi

Bahmani

et al. 2023

Advanced Biomedical Research

View full text Add to dashboard Cite

Background: Traumatic brain injury (TBI) is a leading cause of death among patients in developed countries. The patients' prognosis depends on the trauma-induced primary damage as well as the secondary brain damage, including electrolyte disturbances. Therefore, prevention, diagnosis, and timely treatment lead to better prognosis. Herein, the aim is to prognosticate about the mortality in patients with TBI through serum osmolarity at admission. Materials and Methods: In this cross-sectional study, 141 patients with TBI were assigned through convenience sampling. The level of serum osmolarity was examined once the patients were admitted to emergency department and later, the outcome was recorded. Finally, we analyzed the relationship between osmolarity level and patient outcome in age groups. Results: The mean serum osmolarity in the age group of under 18 years, 18 to 60 years, and more than 60 years was equal to 295.3 ± 10.02 mOsm/L, 297.2 ± 6.5 mOsm/L, and 301.6 ± 7.6 mOsm/L, respectively (P-value <0.001). Osmolarity with a cut-off point of more than 298.90 and sensitivity and specificity of 70.49 and 62.86, respectively, had appropriate diagnostic value for predicting mortality in these patients (P-value <0.001). Conclusion: According to the results of this study, serum osmolarity can have an appropriate diagnostic value in predicting mortality in patients with TBI. In addition, in different age categories, the osmolarity serum in the mortality of these patients was significantly different. Therefore, due to the high importance of serum osmolarity in the mortality of patients, careful monitoring of fluid therapy status of trauma patients should be implemented to prevent the development of hyperosmolarity for the patient with irreversible outcomes.

show abstract

“…This is a descriptive analytical study conducted in 2018 on 70 patients with head trauma under mechanical ventilation who were admitted to the intensive care unit for more than 24 hours. They were selected based on a convenience sampling technique and inclusion criteria which were: having endotracheal intubation, head injury, age 18 years and above, no underlying heart, lung, kidney and thyroid diseases, and Glasgow Coma Scale (GCS) ≥9 [25]. On the other hand, exclusion criteria were: surgery during the study, transfer to another section, spontaneous exit of the endotracheal tube, phosphorus level > 5 mg / dl (hyperphosphatemia) and magnesium level> 2.8 mg /dl (hypermagnesemia).…”

Section: Methodsmentioning

confidence: 99%

Assessment the Relationship Between Phosphorus and Magnesium, Serum Level With Clinical Outcome in Head Trauma Patients

Dr.yekefallah

Mohammadi

Yaghoubi

et al. 2019

J. Qazvin Univ. Med. Sci.

View full text Add to dashboard Cite

Background Traumatic brain injury is the second leading cause of death in Iran. Having knowledge of the factors affecting the clinical outcomes of these patients can improve the therapeutic outcomes. Objective The aim of this study was to determine the relationship of phosphorus (P) and magnesium (Mg) serum levels during admission with clinical outcomes of patients with head trauma. Methods This descriptive-analytic study was conducted in the intensive care unit of Shahid Rajaei Hospital in Qazvin, Iran from March to August 2018. Participants were 70 patients with head trauma under mechanical ventilation who had inclusion criteria. They were selected using a convenience sampling technique. Based on admission P level, patients were divided into two groups of hypophosphatemia (P> 3 mg/dL) and normophosphatemia (P≥3 mg/dL); and based on admission Mg level, they were assigned into two groups of hypomagnesemia (Mg <1.5 mg/dL) and normomagnesemia (Mg ≥1.5 mg/dL). Hypomagnesemia group was compared with normomagnesemia group, and hypophosphatemia group with normophosphatemia group in terms of clinical outcomes. Findings There was a significant difference between two Mg groups in terms of successful weaning (P=0.03), mechanical ventilation duration (P=0.01), and death rate (P=0.03), but not in terms of endotracheal extubation and length of hospital stay (P>0.5). The difference between two P groups was significant only in terms of successful weaning (P=0.006). Conclusion Serum levels of phosphorus and magnesium affect the clinical outcomes of patients with head trauma.

show abstract

Evaluation of the Relationship Between Serum Sodium Concentration and Mortality Rate in ICU Patients with Traumatic Brain Injury

Abstract: Background: Traumatic brain injury (TBI) is a major cause of death and disability globally, and serum sodium disorders are the most common and probably the most poorly understood electrolyte disorders in neurological diseases.

Cited by 6 publications

References 14 publications

Dysnatremia in Traumatic Brain Injury and its Association with Outcome

Dysnatremia in Traumatic Brain Injury and its Association with Outcome

The Level of Serum Osmolarity at Admission in Prognosis of Nosocomial Mortality in Patients with Severe Brain Trauma

Assessment the Relationship Between Phosphorus and Magnesium, Serum Level With Clinical Outcome in Head Trauma Patients

Contact Info

Product

Resources

About