Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients

Abstract

Background: The role of specific IgE (sIgE) against Der p 1 and Der p 2 in Chinese patients with house dust mite (HDM) allergy has not yet been well investigated. Methods: Onehundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity to Dermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP. Results: Almost all patients were sensitized to Der p 1 (95%) and Der p 2 (93%), with both allergens together being largely responsible for the total anti-HDM IgE response. No evidence for a significant role of Der p 10 was found. Overall, IgE responses to HDM and its 2 major allergens were higher in children than in adults in this cross-sectional study. With increasing age, IgE responses to Der p 2 become more important. A positive correlation was observed between the reaction of sIgE against Dp, Der p 1 and Der p 2 and the number of organs (including the eyes, nose, lungs and skin) that were affected in patients. Conclusions: In China, Der p 1 and Der p 2 are the dominant allergens in patients with HDM allergy. The relative importance of Der p 1 and Der p 2 changes with age, in favor of Der p 2. Overall, sIgE titers were positively associated with the number of organs affected.

Molecular Allergen Profiling of Dual Mite Sensitization in Severe Allergic Rhinitis

“…The close correlation between serum IgE titters against Der p1, Der p2 and Der p23, on the one hand, and against D. pteronyssinus on the other, further supports the dominant role of these allergensin the human IgE response against HDM in our area. We also measured IgE against Der p 10 in 63 patients, and5 (8.33%) of them had detectable levels of IgE against this allergen, showing a higher prevalence compared to earlier works from China [39,40].The IgE response against Der p2 and Der p23 represented a larger fraction compared to Der p 1 as shown by former reports in Spain [41]. Mean specific IgE responses to Der p2 and Der p1 allergens were higher to those elicited to Der p23 in terms of quantity.…”

The Dermatophagoides pteronyssinus Molecular Sensitization Profile of Allergic Rhinitis Patients in Central China

“…9 Wang et al showed that Der p1 sensitization was more important in children, while Der p2 sensitization became more dominant in adults and after longer disease duration. 10 Our previous study has found that HDMs, and Der p in particular, are the major aeroallergens among AR patients in Central China, with a sensitization rate of over 90%. 11 Therefore, the aim of this study was to investigate the Der p molecular sensitization profile and its association with clinical manifestations of HDM-AR patients in Central China.…”

Artemisia pollen allergy in China: Component‐resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization

“…Component‐resolved diagnosis (CRD) enables IgE sensitization profiles and potential risk to be established, and whether specific IgE is the result of primary sensitization or cross‐reactivity can also be determined . Such information can assist in making the right choice of immunotherapy, particularly when pollen seasons of different allergenic sources overlap .…”