The growing impact of CO2 and other greenhouse-gas (GHG) emissions on the socio-climate system in the Western Cape, South Africa, urgently calls for the need for better climate adaptation and emissions-reduction strategies. While the consensus has been that there is a strong correlation between CO2 emissions and the global climate system, few studies on climate change in the Western Cape have quantified the impact of climate change on local climate metrics such as precipitation and evaporation under different future climate scenarios. The present study investigates three different CO2 emissions scenarios: Representative Concentration Pathway (RCP) 2.6, RCP 4.5, and RCP 8.5, from moderate to severe, respectively. Specifically, we used climate metrics including precipitation, daily mean and maximum near-surface air temperature, and evaporation to evaluate the future climate in Western Cape under each different RCP climate scenario. The projected simulation results reveal that temperature-related metrics are more sensitive to CO2 emissions than water-related metrics. Districts closer to the south coast are more resilient to severer GHG emissions scenarios compared to inland areas regarding temperature and rainfall; however, coastal regions are more likely to suffer from severe droughts such as the “Day-Zero” water crisis. As a result, a robust drying signal across the Western Cape region is likely to be seen in the second half of the 21st century, especially under the scenario of RCP 8.5 (business as usual) without efficient emissions reduction policies.