Evaluation of the Toxin-to-Protein Binding Rates during Hemodialysis Using Sorbent-Loaded Mixed-Matrix Membranes

Stiapis, Christos S.; Skouras, E. D.; Pavlenko, Denys; Stamatialis, Dimitrios; Burganos, Vasilis N.

doi:10.3390/app8040536

Cited by 7 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase in pore size to increase the removal of such PBUTs face the problem of losing essential proteins, such as albumin [ 13 , 100 ]. Novel approaches try to remove such toxins by using PBUTs adsorbing multilayer membranes or other absorptive methods to remove these toxins from the patients’ blood [ 101 , 102 , 103 ].…”

Section: Discussion Conclusion and Future Directionsmentioning

confidence: 99%

Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance

Zawada

Lang

Ottillinger³

et al. 2022

Membranes

View full text Add to dashboard Cite

The dialyzer is the core element in the hemodialysis treatment of patients with end-stage kidney disease (ESKD). During hemodialysis treatment, the dialyzer replaces the function of the kidney by removing small and middle-molecular weight uremic toxins, while retaining essential proteins. Meanwhile, a dialyzer should have the best possible hemocompatibility profile as the perpetuated contact of blood with artificial surfaces triggers complement activation, coagulation and immune cell activation, and even low-level activation repeated chronically over years may lead to undesired effects. During hemodialysis, the adsorption of plasma proteins to the dialyzer membrane leads to a formation of a secondary membrane, which can compromise both the uremic toxin removal and hemocompatibility of the dialyzer. Hydrophilic modifications of novel dialysis membranes have been shown to reduce protein adsorption, leading to better hemocompatibility profile and performance stability during dialysis treatments. This review article focuses on the importance of performance and hemocompatibility of dialysis membranes for the treatment of dialysis patients and summarizes recent studies on the impact of protein adsorption and hydrophilic modifications of membranes on these two core elements of a dialyzer.

show abstract

Section: Discussion Conclusion and Future Directionsmentioning

confidence: 99%

Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance

Zawada

Lang

Ottillinger³

et al. 2022

Membranes

View full text Add to dashboard Cite

show abstract

“…All these approaches need to be further evaluated in long-term clinical trials to judge their beneficial/risks ratio. Innovative approaches are following different paths such as adding an adsorber on extracorporeal circuit [72,73 ▪ ] or by developing multilayer membrane including sieving and adsorbing capacities [72,74,75]. This is an interesting and fast-moving field of research with high potential clinical values.…”

Section: Future and New Perspectives In Membrane And Dialyzer Technologymentioning

confidence: 99%

Recent advances in dialysis membranes

Canaud

2021

Current Opinion in Nephrology &Amp; Hypertension

View full text Add to dashboard Cite

Purpose of review Improvement in hemodialysis treatment and membrane technology are focused on two aims: the first one is to achieve a better control of circulating uremic solutes by enhancing removal capacity and by broadening molecular weight spectrum of solutes cleared; the second one is to prevent inflammation by improving hemocompatibility of the global dialysis system. Recent findings Despite impressive progresses in polymers chemistry few hazards are still remaining associated with leaching or sensitization to polymer additives. Research has focused on developing more stable polymers by means of additives or processes aiming to minimize such risks. Membrane engineering manufacturing with support of nanocontrolled spinning technology has opened up membrane to middle and large molecular weight substances, while preserving albumin losses. Combination of diffusive and enhanced convective fluxes in the same hemodialyzer module, namely hemodiafiltration, provides today the highest solute removal capacity over a broad spectrum of solutes. Summary Dialysis membrane is a crucial component of the hemodialysis system to optimize solute removal efficacy and to minimize blood membrane biological reactions. Hemodialyzer is much more than a membrane. Dialysis membrane and hemodialyzer choice are parts of a treatment chain that should be operated in optimized conditions and adjusted to patient needs and tolerance, to improve patient outcomes.

show abstract

“…However, the adsorption level seemed to be satisfactory, meaning that the capsulated formulation should be suitable and practical for clinical use. According to other publications, different kinds of absorbents have been used to investigate the adsorption of uremic toxins, as measured using Langmuir isotherms, and they were successful in estimating saturated adsorption [16][17][18][19][20]. In terms of activated carbon absorbance, Wang, W. et al showed that porous activated carbon from rubber seed shells effectively removed creatinine and uric acid, and, using Langmuir isotherms, they elucidated that the level of saturated adsorption of creatinine was 3.81 µmol/mg [21].…”

Section: Evaluation Of Adsorption Capacity Of Uremic Toxins In the Pr...mentioning

confidence: 99%

Adsorption Capacity of Activated Carbon-Encapsulated Hollow-Type Spherical Bacterial Cellulose Gels for Uremic Toxins in a Simulated Human Gastrointestinal Environment

Hirai,

Suzuki,

Sato

et al. 2024

Gels

View full text Add to dashboard Cite

To reduce the risk of the adsorption of granular activated carbon in the gastrointestinal tract, we successfully produced a hollow-type spherical bacterial cellulose (HSBC) gel containing activated carbon with a particle size of 6 μm. In this study, the aim of which was to develop an effective formulation, we evaluated the stability of activated-carbon-encapsulating HSBC gels under various pH conditions. Activated-carbon-encapsulating HSBC gels (ACEGs) retained the activated carbon without leaking when subjected to agitation in acidic or basic environments. The saturated adsorption amount, calculated using the Langmuir adsorption isotherm, was affected by the target adsorbate and pH conditions. These results indicate that ACEGs can adsorb uremic toxins and their precursors similarly to conventional uremic toxin adsorbents while preventing direct contact between the encapsulated activated carbon and the gastrointestinal tract. Compared to powdered activated carbon, the ACEG is less likely to be adsorbed in the gastrointestinal tract. Therefore, the proposed ACEG is a promising new formulation that will contribute to the treatment of renal failure and improve patients’ compliance with medication.

show abstract

Evaluation of the Toxin-to-Protein Binding Rates during Hemodialysis Using Sorbent-Loaded Mixed-Matrix Membranes

Cited by 7 publications

References 30 publications

Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance

Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance

Recent advances in dialysis membranes

Adsorption Capacity of Activated Carbon-Encapsulated Hollow-Type Spherical Bacterial Cellulose Gels for Uremic Toxins in a Simulated Human Gastrointestinal Environment

Contact Info

Product

Resources

About