Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae)

Abstract

Background Medicinal plants play indispensable roles to treat various ailments. Acanthus polystachyus is one of the medicinal plants used traditionally for treatment of wounds. However, there were no scientific reports documented so far on the wound healing activities of this plant. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract of A. polystachyus leaves. Methods The crude extraction was carried out using 80% methanol. The crude extract was prepared in 5% (w/w) and 10% (w/w) ointment and evaluated for wound healing activity using excision, infected, and incision wound models in Swiss albino mice. Results Both 5% and 10% (w/w) ointments significantly reduced period of epithelialization and increased wound contraction rate and tensile strength compared to the negative control group (P < 0.05). The wound healing activity of 10% (w/w) ointment treated group was greater than 5% (w/w) and nitrofurazone ointment treated groups in S. aureus infected wound model. Conclusion These results demonstrate that the crude extract of A. polystachyus leaves possesses wound healing activities. This justifies the traditional claimed use of the plant for treating uninfected and infected wounds caused by S. aureus.

Effect of Hy ect of Hydroalcoholic Extr oalcoholic Extract of T act of Teucrium polium on the eucrium polium on the Process of Wound Healing in Diabetic Rats

“…However, any disturbance in the deposition and maturation of the collagen fibers may reduce wound strength, and cause wound dehiscence [26] . Similar to that of our finding, crude extract of Acanthus polystachyus Delile was found to enhance the rate of wound retraction of excisional and incisional wounds in normal Swiss albino mice [27] . Another study who used Copaifera pauper extrac in diabetic Swiss Webster mice, revealed a better wound closure, and higher level of collagen deposition compared to that of collagenase treated wounds [28] .…”

“…Dewangan, Bais [39] reported a higher regeneration rate with a thinner epidermis in wounds that had been treated with different concentrations of the Solanum xanthocarpum Schrad and Wendl extract. The excisional and incisional wounds, which had been treated with crude extract of Acanthus polystachyus Delile were found to have a faster reepithelialization rate compare to untreated-wounds in Swiss albino mice [27] . Consistence with our finding, Copaifera pauper extract were reported to improve reepithelialization processes in diabetic Swiss Webster mice compared to that of collagenase treated wounds [28] .…”

Medicinal Plants Used In Managing Diseases Of The Respiratory System Among The Luo Community: An Appraisal Of Kisumu East Sub-County, Kenya

“…There is no pharmacological evidence in current literature on the use of Acanthus polystachyus, Keetia guienzii and Rhychosia elegans. However, available literature suggests that Acanthus polystachyus is traditionally indicated for malaria [11], and in the management of scorpion bites [12] while Rhynchosia elegans has been reported to be traditionally used in ethnoveterinary practice in managing backleg, anthrax, amoebiasis, malaria, cold and fever [11,170]. To the best of our knowledge, this study provides the first report of the medicinal use of Keetia guenzii.…”

Solanum incanum extract enhances wound healing and tissue regeneration in burn mice model

“…The percent wound healing of S. incanum (81%) was also far better in comparison to vehicle treated group (23%). These results can be supported by the fact that faster closure of wound indicated the better efficacy of medication (Demilew et al, 2018). Previous studies reveals that the active agents in herbal extracts such as triterpenes, alkaloids, flavonoids, tannins, saponins, anthraquinones, and secondary metabolites have role in promoting the healing process (Chaudhari and Mengi, 2006).…”