Evaluation of Therapeutic and Preventive Action of the Injection Form of Polypeptides in the Experiment on the Model of Periodontitis in Rats

Borodenko, D. I.; Chumakova, Yu. G.

doi:10.35220/2078-8916-2019-32-2-9-14

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“…To date, there is a large number of therapeutic and prophylactic agents that are recommended for use in periodontal diseases [15,16], in particular, containing active peptide complexes [17]. Today, one of the current areas for therapeutic and prophylactic effects on periodontal tissues is the study of the mechanism of action of peptide bioregulators of multicellular systems, in particular, short low molecular weight synthesized peptides of selective action.…”

Section: R E C O O P H S T a S S O C I A T I O N R E C O O P H S T A ...mentioning

confidence: 99%

Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

Avdeev¹,

Drevnitska²,

Gevkaliuk³

et al. 2022

Ukr.Biochem.J.

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The aim of the study was to evaluate changes in the activity of acid and alkaline phosphatases, calcium and phosphorus levels in rats with different courses of experimental gingivitis upon treatment with anti-inflammatory gel with Neovitin and peptide complexes. The experiment was conducted on 100 white nonlinear male rats aged 5-6 months divided into 10 groups: 1 control and 9 – with different courseі of gingivitis. The activity of alkaline and acid phosphatase (ALP, ACP), the levels of calcium (Ca) and phosphorus (P) in rat blood serum and gingiva supernatant were determined. It was found that upon gingivitis, the activity of ALP in blood serum decreased and in gingiva supernatant increased in all groups of animals compared to the control group. The activity of ACP in the serum decreased in hypoergic and hyperergic animal groups and increased in normergia, and in gingiva supernatant increased in all groups: by 2 times in normoergic and hypoergic animals and by 1.4 times in hyperergic. The treatment with anti-inflammatory gel normalized the activity of ALP in both serum and supernatant and decreased the ACP activity in the serum of animals in hypo- and hyperergic groups. The content of serum Ca increased in all groups, and in the supernatant of the gingiva even exceeded the control value. The content of phosphorus in the supernatant of periodontal tissues decreased. The development of the inflammatory process in the periodontium of rats with gingivitis was accompanied by changes in the activity of ACP, ALP, the content of Ca and P in the blood serum and gingival supernatant. The treatment with gel containing neovitin and peptide complexes had a more pronounced therapeutic effect in rats with unchanged reactivity of the organism. Keywords: acid phosphatase, alkaline phosphatase, anti-inflammatory gel, calcium and phosphorus levels, gingivitis

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Section: R E C O O P H S T a S S O C I A T I O N R E C O O P H S T A ...mentioning

confidence: 99%

Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

Avdeev¹,

Drevnitska²,

Gevkaliuk³

et al. 2022

Ukr.Biochem.J.

View full text Add to dashboard Cite

show abstract

Evaluation of Therapeutic and Preventive Action of the Injection Form of Polypeptides in the Experiment on the Model of Periodontitis in Rats

Cited by 1 publication

References 1 publication

Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

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