2013
DOI: 10.4161/cc.27476
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Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy

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Cited by 63 publications
(65 citation statements)
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“…Systemic injection of bortezomib on four alternate days at a clinically relevant dose (0.2 mg/kg) (Meregalli et al, 2014) caused a gradual decrease in the tactile and pressure withdrawal thresholds in 7 rats (Fig. 1).…”
Section: Resultsmentioning
confidence: 98%
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“…Systemic injection of bortezomib on four alternate days at a clinically relevant dose (0.2 mg/kg) (Meregalli et al, 2014) caused a gradual decrease in the tactile and pressure withdrawal thresholds in 7 rats (Fig. 1).…”
Section: Resultsmentioning
confidence: 98%
“…We examined the translocation of PKC-δ and PKC-ε at 0.5, 1 and 6 h after incubation of F11 cells with 10 nM bortezomib. It has been shown that bortezomib at 10 nM is effective in inhibiting proteasome activity (Bil et al, 2010; Meregalli et al, 2014). Our Western blotting analysis demonstrated that the immunoreactivity of PKC-δ and PKC-ε was potentiated on the plasma membrane, whereas their protein levels in the cytosolic fraction were reduced by bortezomib exposure.…”
Section: Resultsmentioning
confidence: 99%
“…*p \ 0.05 Neurotox Res higher than the ones of our study (Staff et al 2013). However, a previous study already demonstrated that embryonic and adult DRG neurons had different sensitivity to bortezomib (Meregalli et al 2013). Therefore, to study the chemotherapy-induced neurotoxicity in vitro, it seems more adequate the use of adult primary neuronal cultures since it is closer to the in vivo model and, thus, to the clinical situation (Staff et al 2013;Meregalli et al 2013).…”
Section: Methodological Differences Between In Vitro Studiesmentioning
confidence: 96%
“…Conversely, other studies proposed that BIPN was mainly due to dysfunctions at the neuronal level, and changes in axons and myelin might be secondary to this initial event (Bruna et al 2010). Other studies reported neuronal alterations after bortezomib exposure, proposing that the neurotoxicity is related either to microtubule polymerization and stabilization (Poruchynsky et al 2008;Staff et al 2013;Meregalli et al 2013) or to nuclear accumulation of ubiquitylated proteins and poly(A)RNAs in nuclear granules, with consequent reduction of transcription and alteration of mRNA translation (Casafont et al 2010;Palanca et al 2013).…”
Section: Introductionmentioning
confidence: 91%
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