Evaluation of Urine NDRG1 as Noninvasive Biomarker for Bladder Cancer Diagnosis

Sun, Yujing; Li, Aiwei; Zhang, Yun-Cong; Dai, Juhua; Zhu, Xi

doi:10.7754/clin.lab.2020.191020

Cited by 4 publications

(1 citation statement)

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“…As is well reported, NDRG1 plays its contradictory role in numerous cancers progression via various signalling pathways. 28 , 29 , 30 NDRG1 is widely supported as a suppressor in prostate cancer, CRC and breast cancer. 14 , 15 , 31 , 32 For example, Dong and his colleagues combined their data with TCGA database, showing that NDRG1 regulated EMT‐associated protein expression (Twist1, Snail, VE‐cadherin and vimentin decreased, whereas E‐cadherin increased) in gastric carcinoma, which is negatively correlated with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Claudin‐2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription

Wei

Zhang

Yang

et al. 2021

Clinical & Translational Med

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Colorectal cancer (CRC) is one of the most common malignant tumours, with multiple driving factors and biological transitions involved in its development. Claudin‐2 (CLDN2), a well‐defined component of cellular tight junction, has been indicated to associate with CRC progression. However, the function of CLDN2 and the underlying mechanism whereby the downstream signalling transduction is regulated in CRC remains largely unclear. In this study, we demonstrated that CLDN2 is upregulated in CRC samples and associated with poor survival. And CLDN2 depletion significantly promotes N‐myc downstream‐regulated gene 1 (NDRG1) transcription, leading to termination of the CRC growth and metastasis in vitro and in vivo. Mechanistically, this process promotes CLDN2/ZO1/ZONAB complex dissociation and ZONAB shuttle into nucleus to enrich in the promoter of NDRG1. Thus, this study reveals a novel CLDN2/ZO1/ZONAB‐NDRG1 axis in CRC by regulating the expression of EMT‐related genes and CDKIs, suggesting CLDN2 may serve as a promising target for CRC treatment.

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Section: Discussionmentioning

confidence: 99%

Claudin‐2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription

Wei

Zhang

Yang

et al. 2021

Clinical & Translational Med

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A new window into fish welfare: A proteomic discovery study of stress biomarkers in the skin mucus of gilthead seabream (Sparus aurata)

Magalhães

Farinha

Carrilho

et al. 2023

Journal of Proteomics

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NDRG1 is being investigated as a possible bladder cancer biomarker in the Iraqi population.

Ibraheem

Ali

Ismail

2022

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With 549,393 new cases recorded in 2018, bladder cancer is one of the most common malignancies worldwide. Urinary bladder cancer is the cause of about 3 percent of all new cancer diagnoses and 2.1 percent of all cancer deaths. This study aims to evaluate the efficiency of the N-myc downstream-regulated gene 1(NDRG1) as a biomarker for bladder cancer patients in the Iraqi population. One hundred individuals in the case-control study were enrolled and divided into two groups. The first group included 50 patients diagnosed with a bladder mass and investigated by undergoing cystoscopy examination for transurethral resection of bladder tumor (TURB). The second group included 50 healthy individuals who had normal bladder tissue. The results of the present study showed the highest level of (NDRG1) among cases with statically significant association (p=0.001). The ROC curve demonstrated that the protein level of (NDRG1) could distinguish disease patients from healthy individuals with a sensitivity of 96% and a specificity of 92%. Serum (NDRG1) protein is an efficient and noninvasive tumor marker for diagnosing bladder cancer. Keywords: N-myc downstream-regulated gene 1 (NDRG1), non-muscle-invasive bladder cancer (NMIBC), transurethral resection of bladder tumor (TURB).

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Evaluation of Urine NDRG1 as Noninvasive Biomarker for Bladder Cancer Diagnosis

Cited by 4 publications

References 0 publications

Claudin‐2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription

Claudin‐2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription

A new window into fish welfare: A proteomic discovery study of stress biomarkers in the skin mucus of gilthead seabream (Sparus aurata)

NDRG1 is being investigated as a possible bladder cancer biomarker in the Iraqi population.

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