Evaluation of Varicella Immune Status in an Obstetric Population in Relation to Place of Birth

Goldberg, Jay M.; Ziel, Harry K.; Burchette, Raoul J.

doi:10.1055/s-2002-35613

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…As in other studies, we found a very high positive predictive value of varicella history (6,13,28,29,37). However, we found a strikingly low predictive value of negative history (i.e., 2.5%); therefore, a high percentage of women with negative or uncertain history of varicella were immune.…”

Section: Discussionsupporting

confidence: 80%

Varicella Seroprevalence and Molecular Epidemiology of Varicella-Zoster Virus in Argentina, 2002

et al. 2004

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There is limited data on immunity against varicella-zoster virus (VZV) in adults in different parts of Argentina, and it is not known which VZV strains are circulating in Argentina. The objectives of this study were as follows: (i) to evaluate seroprevalence of varicella among adults, assessing the accuracy of clinical history and determining the sociodemographic factors associated with seropositivity; and (ii) to determine the VZV strains circulating in Argentina. A cross-sectional serological survey enrolling 2,807 women aged 15 to 49 years attending public health-care settings in four cities in Argentina (i.e., Buenos Aires, Salta, Mendoza, and Rosario) and one rural area was conducted from August to November 2002. Specimens for identification of VZV strains were obtained from vesicular lesions from 13 pediatric patients with varicella from different areas of the country. PCR amplification was used for genotyping. The overall seroprevalence of varicella antibodies was 98.5% (95% confidence interval, 98.0 to 98.9), ranging from 97.2% in central Buenos Aires to 99.3% in southern Buenos Aires and Salta. Varicella seroprevalence increased with age. Crowding and length of residence in the same place were associated with seropositivity. The positive predictive value of varicella history for immunity to varicella was 99.4%; however, the negative predictive value was 2.5%. The European genotype was identified in all viral specimens. In Argentina, seroprevalence in women more than 15 years old was high regardless of the area of residence. Negative or uncertain varicella history was not a good predictor of immunity. VZV genotype was stable in all areas of the country.

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Section: Discussionsupporting

confidence: 80%

Varicella Seroprevalence and Molecular Epidemiology of Varicella-Zoster Virus in Argentina, 2002

et al. 2004

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“…It is well known that in tropical countries, VZV infection occurs more often in adults [19,20]. In the present study, 19 women spent their childhood in tropical countries.…”

Section: Discussionmentioning

confidence: 83%

Seroprevalence of varicella antibodies among pregnant women in Lyon-France

et al. 2007

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The purpose of the study was to calculate the seroprevalence of immunity to the varicella-zoster virus (VZV) infection and to evaluate the positive predictive value (PPV) and the negative predictive value (NPV) of the self-reported history of VZV infection in pregnant women. A cross sectional study was conducted in 18 private medical analysis laboratories. Information on socio-demographic characteristics and past history of varicella or zoster were collected using a questionnaire. Blood samples were obtained to determine the serological levels of past exposure to VZV. Overall, 486 pregnant women were recruited. The seroprevalence of VZV antibodies was 98.8%. Six women were seronegative, of whom four were primiparous. The PPV was high (99.5%) while the NPV was only 10.3%. The PPV is a reliable marker of prior VZV infection. In contrast, a negative history does not predict lack of immunity and should be completed by serological analysis which might be introduced to routine antenatal blood tests.

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“…Nationally representative data from the National Health and Nutrition Examination Surveys (NHANES) administered from 1988-1994 showed varicella seroprevalence rates steadily increasing from 86% among 6-to 11-year-olds to 99.6% among adults aged 40 to 49 years. 19 In AV, the median age of the seropositive subjects was 24 years compared to 21 years among those who were seronegative; in Philadelphia, the median age was 23 years for the seropositive subjects and 24.5 years for the seronegative subjects (data not shown). NHANES data also demonstrated that race was associated with naturally acquired varicella infection independent of age, with non-Hispanic black women aged 20 to 39 years being 60% less likely to be varicella seropositive compared to their non-Hispanic white counterparts.…”

Section: Discussionmentioning

confidence: 87%

Validity of Self-Reported Varicella Disease History in Pregnant Women Attending Prenatal Clinics

et al. 2007

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Evaluation of Varicella Immune Status in an Obstetric Population in Relation to Place of Birth

Cited by 8 publications

References 16 publications

Varicella Seroprevalence and Molecular Epidemiology of Varicella-Zoster Virus in Argentina, 2002

Varicella Seroprevalence and Molecular Epidemiology of Varicella-Zoster Virus in Argentina, 2002

Seroprevalence of varicella antibodies among pregnant women in Lyon-France

Validity of Self-Reported Varicella Disease History in Pregnant Women Attending Prenatal Clinics

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