Evaluation of wound contraction and epithelialization after subcutaneous administration of Theranekron® in cows

Novel Application of Theranekron® Enhanced the Structural and Functional Performance of the Tenotomized Tendon in Rabbits

“…On days 3, 7 and 10 after injury, 1.0 mg/ml of TC extract in alcoholic solution (1: 100; Theranekron , Richter Pharma, Wels, Austria) was diluted in normal 0.9% saline and injected at a dose of 1 g/kg s.c. through the window into the cast at the injury site in accordance with previous studies [Sardari et al, 2007;Mates et al, 2008] and the manufacturer's recommendations. The same volume of 0.9% physiological sterile saline was injected subcutaneously at the site of injury in the injured control group at the same time.…”

“…It has also been claimed that it reduces inflammation and stimulates re-epithelialization of the full thickness cutaneous wounds in cows during the first 14 days after injury [Sardari et al, 2007;Albay et al, 2010] and enhances healing or resolution of infection in a wide range of lesions [Çam and Kibar, 2007;Kaçar et al, 2007].…”

Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing

“…Contraction of the wound is likely provided by myofibroblasts and is an active normal process that reduces the size of a wound by centripetal movement of the dermis and epidermis that border the defect [40,41]. Epithelialization is the process by which cells from the epidermis at the edge of a wound proliferate and migrate to cover the surface of the cutaneous defect [40,42]. Activated carbon dressings provide a moist wound healing environment for autolytic debridement.…”

“…Contraction and epithelialization are the most important factors in wound healing [39,40]. Contraction of the wound is likely provided by myofibroblasts and is an active normal process that reduces the size of a wound by centripetal movement of the dermis and epidermis that border the defect [40,41]. Epithelialization is the process by which cells from the epidermis at the edge of a wound proliferate and migrate to cover the surface of the cutaneous defect [40,42].…”

“…Contraction and epithelialization are the most important factors in wound healing [39,40]. Contraction of the wound is likely provided by myofibroblasts and is an active normal process that reduces the size of a wound by centripetal movement of the dermis and epidermis that border the defect [40,41].…”