Evaluation the aggressive reaction of varicella in young adult immune system compared to children immune response

Abstract

The immune system is a defense system, both children, and adult have the same reaction toward pathogen, uses multiple defense mechanisms evolved to recognize and neutralize pathogens also have the ability to distinguish self from non-self cells, but in case of Varicella-zoster virus (VZV) that cause chicken pox, the immune system reacts differently in young healthy adult usually have an aggressive reaction serious complications can lead to death, compare with children infection is usually mild. This overview illustrates the chickenpox and difference of immune response between the children and young adult toward infection with the varicella-zoster virus.

Chickenpox Associated Retinitis and Occlusive Vasculitis: A Case Report and Literature Review

“…Hypothetically, it is possible, that existence of the aggressively strong and potent cell mediated immune response to VZV in adults may be harmful for the host, leading to excessive damage of infected cells which consequently lead to more severe disease and higher percentage of complications. The strongest cell-mediated immune responses to VZV appear to be in early adulthood ( 16 ).…”