Evidence-Based Systematic Review of Saw Palmetto by the Natural Standard Research Collaboration*

Ulbricht, Catherine; Basch, Ethan; Bent, Steve; Boon, Heather; Corrado, Michelle M.; Foppa, Ivo; Hashmi, Sadaf; Hammerness, Paul; Kingsbury, Eileen; Smith, Michael; Szapary, Philippe; Vora, Mamta; Weissner, Wendy

doi:10.2310/7200.2006.016

Cited by 13 publications

(25 citation statements)

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“…Among them, hard copies of 24 studies were reviewed. The characteristics of the reviewed and excluded studies are presented in Table 1 [5,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Of 24 studies, 6 SRs were included in this overview ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Reason for exclusion Agbabiaka (2009) [12] Invalid outcome assessment Dedhia (2008) [13] Overview of systematic reviews Dvorkin (2002) [14] Overview Fong (2005) [15] Overview of systematic reviews Gaynor (2003) [16] Narrative review Gerber (2004) [17] Narrative review Ilic (2012) [18] Invalid outcome assessment Ishani (2000) [19] Duplication Lowe (2009) [20] Overview of systematic reviews Macdonald (2012) [21] Duplication Madersbacher (2007) [22] Narrative review McNicholas (2011) [5] Overview of systematic reviews Sosnowska (2009) [23] Invalid outcome assessment Strong (2004) [24] Narrative review Ulbricht (2006) [25] Overview of systematic reviews Webber (2006) [26] Updated review Wilt (2002) [27] Updated review Wilt (1999) [28] Duplication…”

Section: Study (First Author Year Published)mentioning

confidence: 99%

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Dietary supplements for benign prostatic hyperplasia: An overview of systematic reviews

2012

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Section: Resultsmentioning

confidence: 99%

Section: Study (First Author Year Published)mentioning

confidence: 99%

Dietary supplements for benign prostatic hyperplasia: An overview of systematic reviews

2012

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Section: Discussionmentioning

confidence: 99%

“…SP have a long standing use in the treatment of mild to moderate LUTS and ED 3, 4, 5, 6, 7. More than 30 controlled clinical trials evaluating treatments for LUTS and SDys have demonstrated long-term efficacy 5, 6, 7. The plant, which is indigenous to Florida, was first used by white settlers in the United States not only for treatment of LUTS but also a treatment for ED, to improve testicular atrophy and sperm production 3, 4.…”

Section: Discussionmentioning

confidence: 99%

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Effects of a supplement combining Pycnogenol® and l-arginine aspartate on lower urinary dysfunction compared with saw palmetto extract

Yagi

Sato

Nishio

et al. 2017

Journal of Traditional and Complementary Medicine

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ObjectivesLower urinary tract symptoms (LUTS) and sexual dysfunction (SDys) are common problems that affect quality of life (QOL) in elderly men. In addition to prescribed drugs, many over-the-counter medications including supplements are used to treat QOL diseases. Phosphodiesterase inhibitors are reported to be effective for both LUTS and SDys by increasing nitric oxide levels. French maritime pine bark extract Pycnogenol®, which is a potent nitric oxide donor, is reported to be effective for SDys. However, no reports have been published on whether it ameliorates LUTS.DesignOpen-labeled, randomized study. The effects of two supplements, Nokogiriyashi EX® containing 160 mg saw palmetto (SP) extract per tablet and Edicare® containing 10 mg of Pycnogenol®, 115 mg of l-arginine and 92 mg of aspartate (PAA) per tablet on International Prostate Symptom Score (IPSS), IPSS–QOL, Overactive Bladder Symptom Score (OABSS), International Index of Erectile Function 5 (IIEF5), Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), urinary 8-OHdG and uroflowmetry (UFM) of total 40 men with LUTS and SDys were examined.Results19 subjects were instructed to take two tablets of SP, on the other 20 were on four tablets of PAA for 16 weeks. IPSS and IPSS–QOL showed statistically significant improvements in both groups. OABSS and IIEF5 were significantly improved in the PAA group. Conversely, ICIQ-SF, 8-OHdG and UFM did not change in either group.ConclusionsPAA might be an effective therapeutic alternative for elderly patients with LUTS and SDys.

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Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial

Suter

Saller

Riedi³

et al. 2012

Phytotherapy Research

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In elderly men, benign prostatic hyperplasia (BPH) is a major risk factor for sexual dysfunctions (SDys). Additionally, the standard treatments for BPH symptoms, alpha blockers and 5-alpha-reductase inhibitors, cause SDys themselves. Preparations from saw palmetto berries are an efficacious and well-tolerated symptomatic treatment for mild to moderate BPH and have traditionally been used to treat SDys. We conducted an open multicentric clinical pilot trial to investigate whether the saw palmetto berry preparation Prostasan® influenced BPH symptoms and SDys. Eighty-two patients participated in the 8-week trial, taking one capsule of 320 mg saw palmetto extract daily. At the end of the treatment, the International Prostate Symptom Score was reduced from 14.4 ± 4.7 to 6.9 ± 5.2 (p < 0.0001); SDys measured with the brief Sexual Function Inventory improved from 22.4 ± 7.2 to 31.4 ± 9.2 (p < 0.0001), and the Urolife BPH QoL-9 sex total improved from 137.3 ± 47.9 to 195.0 ± 56.3 (p < 0.0001). Investigators' and patients' assessments confirmed the good efficacy, and treatment was very well tolerated and accepted by the patients. Correlation analyses confirmed the relationship between improved BPH symptoms and reduced SDys. This was the first trial with saw palmetto to show improvement in BPH symptoms and SDys as well. [Corrections made here after initial online publication.]

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Evidence-Based Systematic Review of Saw Palmetto by the Natural Standard Research Collaboration*

Cited by 13 publications

References 0 publications

Dietary supplements for benign prostatic hyperplasia: An overview of systematic reviews

Dietary supplements for benign prostatic hyperplasia: An overview of systematic reviews

Effects of a supplement combining Pycnogenol® and l-arginine aspartate on lower urinary dysfunction compared with saw palmetto extract

Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial

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