Evidence for a Non-Thyroxine Thyroid Factor Which Affects Gastric Function

Watman, Robert N.; Nasset, E. S.

doi:10.1152/ajplegacy.1951.166.1.131

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1955

1974

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Cited by 9 publications

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“…Furthermore, in dogs, feeding whole dessicated thyroid caused a significant fall in volume of gastric juice and in the quantity of HCI secreted (Nasset, Logan, Kelleyand Thomas 1959). Dur work, as weil as previous results observed in rats (Bates and Barlet 1974) and in guinea-pigs (Barlet and Bates 1974) support the hypothesis that calcitonin might be "the substance other than thyroxine produced by the thyroid, which regulates gastric acidity" (Watman and Nasset 1951).…”

Section: Discussionsupporting

confidence: 87%

The Influence of Porcine Calcitonin Given Intragastrally on Restraint-Induced Gastric Ulcers in Pigs

Barlet¹

1974

Horm Metab Res

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Gastric ulcers, located in the fundic area, appeared in pigs restrained during a 24 hrs period. Tbe development of tbese uleers was prevented by poreine calcitonin (P-CT) given intramuscuiarly or intragastraIly, at 5 hrs intervals, during tbe restraint period. P-CT increased significantly tbe pH of gastrie secretion at the end of restraint. In non-restrained fasting pigs, P-CT given intragastraIly strongly inbibited basal or gastrin-stimulated acid output. These results tend to indicate that P-CT prevented restraint-induced gastric ulcer in pigs, probably by inbibiting gastric HCl secretion.

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Section: Discussionsupporting

confidence: 87%