Evidence for downregulation of hypothalamic 5‐hydroxytryptamine receptor function in endurance‐trained athletes

Jakeman, Philip M.; Hawthorne, J. E.; Maxwell, Scott; Kendall, M J; Holder, G.

doi:10.1113/expphysiol.1994.sp003780

Cited by 50 publications

(36 citation statements)

References 9 publications

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“…Jakeman et al (1994) found a reduced prolactin response to buspirone in highly trained endurance athletes compared with healthy controls. It has been suggested that a higher aerobic fitness provides an advantage during exercise in the heat with an improved ability to tolerate a high core temperature at exhaustion (Selkirk and McLellan 2001).…”

Section: Introductionmentioning

confidence: 82%

“…A common technique used to assess hypothalamic 5-HT sensitivity in healthy subjects is to measure the blood prolactin response to a neuroendocrine challenge with buspirone (Meltzer et al 1983;Anderson and Cowen 1992;Bakheit et al 1992;Jakeman et al 1994;Sharpe et al 1996;Bridge et al 2001). Jakeman et al (1994) found a reduced prolactin response to buspirone in highly trained endurance athletes compared with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

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Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function

Bridge

Weller

Rayson³

et al. 2003

Eur J Appl Physiol

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We have studied 12 recreationally active men to measure their responses to exercise in the heat and relate these to measures of hypothalamic function explored with a buspirone [5-hydroxytryptamine 1A (5-HT(1A)) agonist, dopaminergic D(2) antagonist] neuroendocrine challenge, with and without pretreatment with pindolol (5-HT(1A) antagonist). Pindolol treatment allowed the serotonergic and non-serotonergic components of prolactin release to be distinguished. Subjects exercised at 73 (5)% maximal rate of oxygen uptake (VO(2max)) until volitional fatigue at 35 degrees C (relative humidity, 30%). On another two occasions they underwent a buspirone challenge [0.5 mg (kg body mass)(-1)], once with, and once without, pindolol [0.5 mg (kg body mass)(-1)] pretreatment and the circulating plasma concentrations of prolactin were measured for the next 2.5 h. Rectal temperature increased throughout exercise, whilst mean skin temperature remained constant. There was a wide inter-subject variation in prolactin response to the neuroendocrine challenges. The proportion of the prolactin response to buspirone attributable to a non-serotonergic component (most likely dopaminergic) correlated both with exercise duration (r=0.657, P=0.028), rectal temperature at fatigue (r=0.623, P=0.041) and the rate of temperature rise (r=-0.669, P=0.024). Our results suggest that high activity of the dopaminergic pathways in the hypothalamus is a predictor of exercise tolerance in the heat.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function

Bridge

Weller

Rayson³

et al. 2003

Eur J Appl Physiol

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“…Additionally, a number of studies employing different markers of 5-HT receptor function suggest that differences in the sensitivity of the 5-HT system to manipulation may exist between individuals. Marked inter-individual differences in platelet 5-HT transporter density (Strachan and Maughan 1998;Struder et al 1999) and in the prolactin response to a buspirone challenge (Bridge et al 2003;Jakeman et al 1994) are reported in the published literature. Additionally, patients suffering from chronic fatigue syndrome appear to possess an altered sensitivity of central serotonergic receptors (Bakheit et al 1992).…”

Section: Discussionmentioning

confidence: 99%

The effect of acute branched-chain amino acid supplementation on prolonged exercise capacity in a warm environment

2004

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Eight males were recruited to examine the effect of branched-chain amino acid (BCAA) supplementation on exercise capacity in a glycogen-depleted state in a warm environment. Following a exercise and dietary regimen designed to reduce glycogen availability, subjects returned to the laboratory the following morning and remained seated for 2 h, before cycling to volitional exhaustion at 50% VO2 peak in a warm environment [30.0 (0.2) degrees C; mean (SD)]. Four 250 ml aliquots of a 12 g l(-1) BCAA solution or placebo were ingested at 30 min intervals prior to exercise, with an additional 150 ml consumed every 15 min throughout exercise. BCAA ingestion had no effect on exercise capacity [placebo 103.9 (26.9) min; BCAA 111.0 (29.2) min; P = 0.129). No difference in heart rate (P = 0.345), core temperature (P = 0.628), or weighted mean skin temperature (P = 0.114) was apparent between trials. Ingestion of the BCAA solution produced a marked increase in plasma BCAA immediately prior to exercise [+ 1126 (158) micromol l(-1); P < 0.001) with this difference maintained throughout. Consequently, a significant reduction in the plasma concentration ratio of free tryptophan to BCAA was observed during the BCAA trial when compared to the placebo (P < 0.001). Plasma ammonia concentration was significantly elevated during exercise throughout the BCAA trial (P < 0.001), with no change from rest apparent during the placebo trial (P = 0.608). Blood glucose (P = 0.114) and lactate (P = 0.836) concentrations were not different between trials. Ingestion of a BCAA solution prior to, and during, prolonged exercise in glycogen-depleted subjects did not influence exercise capacity in a warm environment.

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“…Em outras palavras, maior densidade do transportador de serotonina na membrana de plaquetas, menor concentração de triptofano. Do mesmo modo, J et al 30 , ao compararem a atividade serotoninérgica por meio da Prolactina entre indivíduos aerobiamente treinados (atletas de endurance) e não treinados, demonstraram que indivíduos treinados apresentam um pico de Prolactina (486 ± 208 mU l -1 ) estatisticamente inferior (p = 0,031) em comparação aos sujeitos não treinados (1000 ± 385 mU l -1 ). O que em parte pode explicar a não ocorrência de aumento do triptofano e, presumivelmente, da síntese de serotonina no presente estudo.…”

Section: Discussionunclassified

Efeitos agudos de diferentes intensidades e volumes de exercício aeróbio sobre as concentrações de triptofano e serotonina em mulheres idosas fisicamente ativas

Barros

Sales

Browne

et al. 2014

Rev. bras. educ. fís. esporte

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O envelhecimento provoca uma diminuição na concentração de serotonina, que por sua vez, pode produzir anormalidades de comportamento como: agressividade, insônia, comportamento suicida ou criminal e perda do desejo sexual. Entretanto, estudos demonstram que o exercício aeróbio parece aumentar agudamente as concentrações de triptofano e serotonina. Por outro lado, não há relatos na literatura de estudos que tenham investigado os efeitos de diferentes intensidades e volumes de exercício aeróbio sobre as concentrações de triptofano e serotonina em mulheres idosas. O objetivo do presente estudo foi verificar os efeitos agudos de diferentes intensidades e volumes de exercício aeróbio sobre as concentrações de triptofano e serotonina em mulheres idosas fisicamente ativas. Para tanto, 49 mulheres idosas (idade entre 60 e 75 anos), fisicamente ativas, foram distribuídas em seis grupos: controle (GC; n = 8) e cinco experimentais: 1) exercício aeróbio realizado a 90% do limiar ventilatório (LV90; n = 8); 2) exercício realizado em intensidade de limiar ventilatório (LV; n = 8), 3) exercício realizado em intensidade relativa a 90% do ponto de compensação respiratório (PCR90; n = 8), todos com duração de 20 min; 4) teste de esforço máximo (Gmáx; n = 8); e 5) exercício realizado em intensidade de limiar ventilatório com duração de 60 min (LV60min; n = 9). Antes e após a realização das sessões de exercícios foram realizadas coletas de sangue venoso para quantificação das concentrações de triptofano e serotonina. Não foram identificadas diferenças significativas (p > 0,05) entre (GC, LV90, LV, PCR90, Gmáx e LV60min) e intragrupos (pré e pós) nas concentrações de serotonina e triptofano. Em conclusão, sessões agudas de exercício aeróbio realizado em diferentes intensidades e volumes não resultaram em alterações significativas nas concentrações de serotonina e tripotofano em mulheres idosas.

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Evidence for downregulation of hypothalamic 5‐hydroxytryptamine receptor function in endurance‐trained athletes

Cited by 50 publications

References 9 publications

Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function

Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function

The effect of acute branched-chain amino acid supplementation on prolonged exercise capacity in a warm environment

Efeitos agudos de diferentes intensidades e volumes de exercício aeróbio sobre as concentrações de triptofano e serotonina em mulheres idosas fisicamente ativas

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