Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats

Hatware, Ketan; Sharma, Sanjay; Patil, Kiran; Shete, Meghanath B.; Karri, Sravani; Gupta, Gaurav

doi:10.1016/j.biopha.2018.04.007

Cited by 82 publications

(63 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL‐1β and IL‐6 are a key mediator of the inflammatory reaction, and they are associated with an assortment of cell activities, including cell multiplication, separation, and apoptosis. [ 34,35 ] To activate the expression of different inflammation cytokines (TNF‐α, IL‐1β, and IL‐6) and to initiate NF‐кB, [ 36,37 ] paraquat has recently been accounted for. This is consistent with the information introduced in this report.…”

Section: Discussionmentioning

confidence: 99%

Embelin impact on paraquat‐induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF‐κB signaling pathway

Sreeharsha

2020

J Biochem & Molecular Tox

View full text Add to dashboard Cite

The current examination was intended to observe the defensive impacts of embelin against paraquat‐incited lung damage in relationship with its antioxidant and anti‐inflammatory action. Oxidative stress marker, like malondialdehyde (MDA), antioxidative enzymes, for example, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH Px), inflammatory cytokines, such as interleukin‐1β (IL‐1β), tumor necrosis factor‐α, and IL‐6, histological examination, and nuclear factor kappa B/mitogen‐activated protein kinase (NF‐κB/MAPK) gene expression were evaluated in lung tissue. Embelin treatment significantly decreased MDA and increased SOD, CAT, and GSH Px. Embelin significantly reduced levels of inflammatory cytokines in paraquat‐administered and paraquat‐intoxicated rats. In addition, embelin suggestively decreased relative protein expression of nuclear NF‐κB p65, p‐NF‐κBp65, p38 MAPK, and p‐p38 MAPKs in paraquat‐intoxicated rats. The outcomes show the impact of embelin inhibitory action on NF‐κB and MAPK and inflammatory cytokines release, and the decrease of lung tissue damage caused by paraquat.

show abstract

Section: Discussionmentioning

confidence: 99%

Embelin impact on paraquat‐induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF‐κB signaling pathway

Sreeharsha

2020

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…ROS leads to oxidative stress that can cause severe cell injury, thus leading to the pathogenesis of many other notable diseases (Hatware et al, ; Uttara, Singh, Zamboni, & Mahajan, ). The present study confirms an increase in the LPO level in GM administered rats, which is observed in their renal tissue (measured as MDA), which exposes the kidney cells to free oxygen radicals (Lobo, Patil, Phatak, & Chandra, ).…”

Section: Discussionmentioning

confidence: 99%

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

et al. 2019

View full text Add to dashboard Cite

Gentamicin (GM) is an antibiotic related to aminoglycoside group that is used in treating Gram‐negative bacterial infections. However, treatment with gentamicin is considered to be limited as it induces an oxidative stress‐mediated apoptosis in kidney which causes a nephrotoxicity. Metformin is a well‐known biguanide that is used for treating diabetes mellitus, especially type 2. Supplement with plant metabolites or natural antioxidants produce a protective activity against many types of diseases in vivo. Curcumin is a main medicinal constituent of Curcuma longa, has reported for number of biological effects, such as antioxidant, anti‐inflammatory, and antitumor. The study aims at evaluating the metformin and curcumin alone or in combination on nephrotoxicity induced by GM. The outcome of the study shows that both metformin and curcumin, when used unaided, were effectively decreasing GM‐induced nephrotoxicity. The two drugs combination was showed synergistic effect in ameliorating a GM‐induced kidney injury, as supported by expressively improved renal dysfunction. Metformin and curcumin showed strong protection against oxidative stress in GM treated animals through decreasing the activities and expression of various antioxidative enzymes. Moreover, combination of two drugs showed an anti‐inflammatory response through reducing a level of pro‐inflammatory cytokines including tumor necrosis factor‐alpha, interleukin 1‐beta, and interleukin 6 in GM intoxicated group of animals. Furthermore, GM agitated apoptosis was affectedly diminished by the combinational treatment of metformin and curcumin via down‐regulating activity of cleaved Caspase‐3 and pro‐apoptotic factor Bax, whereas increasing anti‐apoptotic factor Bcl‐2 signaling pathways. The above results suggested that combinational treatment of metformin and curcumin might be have a synergizing effect and substantial potential against nephrotoxicity induced by GM. Practical applications Curcumin and metformin combination exhibited substantial synergistic effect against GM‐induced nephrotoxicity through reducing oxidative stress, inflammation, as well as apoptosis in kidney cells. Therefore, the method of combination of curcumin and metformin might be functional to treat or inhibit GM prompted nephrotoxicity in future.

show abstract

“…Damaging effects triggered by ROS happen because of unevenness between the formation and inactivation of these agents prompting disruption in normal cell physiology and distinctive pathological conditions. Free oxidative radicals (FOR) have been associated in the pathogenesis of numerous degenerative diseases, for example, malignant growth, coronary illness, rheumatoid joint inflammation, stroke, diabetes, Alzheimer's, and the aging process …”

Section: Discussionmentioning

confidence: 99%

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Shi

Zhang

Wang

et al. 2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Deltamethrin (DLM) is a synthesized organophosphorus acaricide and bug spray, broadly utilized for veterinary and farming purposes. Although its exposure to humans and animals causes toxicity in the kidney and other primary organs, our objective was to assess the defensive effects of sitagliptin (Sita) and additionally curcumin (Cur) in the DLM‐intoxicated rats’ kidney. DLM‐intoxicated rats revealed a huge increase of various biochemical parameters in serum identified with kidney damage: uric acid, urea, and creatinine. DLM intoxication altogether increased renal lipid peroxidation, and critically restrained antioxidative biomarkers including superoxide dismutase, glutathione, and glutathione peroxidase. Likewise, it increased the tumor necrosis factor‐α, interleukin 6 (IL‐6) and IL‐1β level in serum. Additionally, DLM intoxication diminished the outflow of the nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2)/heme oxygenase‐1 (HO‐1) pathway in rats. Both Sita and Cur act against DLM‐prompted serum along with renal tissue biochemical parameters when utilized alone or in a mix alongside DLM intoxication. Besides this, both Sita and Cur delivered synergetic nephroprotective, antioxidative, and anti‐inflammatory impacts. Consequently, it could be presumed that Sita as well as Cur administration can limit the poisonous impacts of DLM by their free radical‐scavenging, strong antioxidant, and Nrf2/HO‐1 pathway upregulation activity.

show abstract

Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats

Cited by 82 publications

References 37 publications

Embelin impact on paraquat‐induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF‐κB signaling pathway

Embelin impact on paraquat‐induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF‐κB signaling pathway

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Contact Info

Product

Resources

About