Evidence for instrument and family-specific variation of subclinical psychosis dimensions in the general population.

Abstract

It is unknown to what degree dimensions of schizotypy (subclinical psychosis) show independent, family-specific variation in the general population. Psychologists administered the Community Assessment of Psychic Experiences, the Structured Interview for Schizotypy-Revised (SIS-R), and the Brief Psychiatric Rating Scale to 257 subjects pertaining to 82 general population families. All 3 instruments showed family-specific variation for positive and negative subclinical psychosis dimensions with between-families proportions of total variance between 10% and 40%. However, only the SIS-R showed family-specific variation of the negative dimension independent of its correlation with the positive dimension. The positive dimension of subclinical psychosis shows familial-specific variation in samples unselected for psychiatric disorder, suggesting dimensional liability in the population. The SIS-R additionally captures family-specific variation in the negative domain.

The psychometric properties of the Peters et al. Delusions Inventory (PDI) in Taiwan: reliability, validity, and utility

“…Fourth, the data are based solely on self-report measures. Hanssen et al [68] discussed the need to combine self-report and interviewbased measures of subclinical psychosis, as results can differ. However, the goal of this research was to validate the Taiwanese version of the PDI, rather than to engage in a detailed understanding of phenomena, and we expect that the limitations of self-report measures affected our three groups equally.…”

Childhood abuse and neglect in relation to the presence and persistence of psychotic and depressive symptomatology

“…Guided by previous research (Hanssen et al 2006), item scores were reduced a priori to two-dimensional scores, representing the means of positive schizotypy items (e.g. referential thinking, psychotic phenomena and derealization; range 0-2.7) and negative disorganized schizotypy items (e.g.…”

Childhood trauma and schizotypy: a systematic literature review

“…There is also evidence of aetiological continuity with familial co-clustering of the clinical and the subclinical (Kendler et al 1993), sharing of risk genes (MacDonald et al 2001;Linney et al 2003;Stefanis et al 2004a), sharing of other environmental risk factors such as cannabis Arseneault et al 2004;Hanssen et al 2006) and childhood trauma (Read et al 2005;Steel et al 2009;Lovatt et al 2010), dose-response effects of the early environment , similar neurocognitive deficits (Dinn et al 2002;Bergida & Lenzenweger, 2006;Cochrane et al 2012), and also similar associations with demographic factors, for example sex differences (Roy et al 2001), age-related reduction in schizotypal traits/psychosis-proneness and the positive association with social disadvantage (Verdoux et al 1998;Peters et al 1999;van Os et al 2000;Johns & van Os, 2001).…”