Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions

Casa, C. La; Villegas, Isabel; Lastra, Catalina Alarcón de la; Motilva, Virginia; Calero, María José Martin

doi:10.1016/s0378-8741(99)00174-9

Cited by 484 publications

(321 citation statements)

References 32 publications

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“…They promote gastric mucosa formation, diminish acid mucosal secretion, inhibit the production of pepsinogen and decrease ulcerogenic lesions (33).…”

Section: Herbal Medicines and Natural Compoundsmentioning

confidence: 99%

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Repetto

Llesuy

2002

Braz J Med Biol Res

432

277

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There is evidence concerning the participation of reactive oxygen species in the etiology and physiopathology of human diseases, such as neurodegenerative disorders, inflammation, viral infections, autoimmune pathologies, and digestive system disorders such as gastrointestinal inflammation and gastric ulcer. The role of these reactive oxygen species in several diseases and the potential antioxidant protective effect of natural compounds on affected tissues are topics of high current interest. To consider a natural compound or a drug as an antioxidant substance it is necessary to investigate its antioxidant properties in vitro and then to evaluate its antioxidant functions in biological systems. In this review article, we shall consider the role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol.

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“…They promote gastric mucosa formation, diminish acid mucosal secretion, inhibit the production of pepsinogen and decrease ulcerogenic lesions (33).…”

Section: Herbal Medicines and Natural Compoundsmentioning

confidence: 99%

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Repetto

Llesuy

2002

Braz J Med Biol Res

432

277

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“…Apparently, the free radical scavenging property of drugs may contribute to reduce the progression of such oxidative damage to gastric mucosa (Bhattacharya, Chaudhuri, Chattopadhyay, & Bandyopadhyay, 2007; Oyagi et al., 2010). It has been accepted that free radical scavengers exert protective functions on mucosal damage triggered by excessive production of free radicals (Ahn et al., 2001; Cantürk, Cantürk, Ozbilim, & Yenisey, 2000; La Casa, Villegas, Alarcón de la Lastra, Motilva, & Martín Calero, 2000; Yoshinaga, Ohtani, Harada, Fukuda, & Nawata, 2001). Therefore, potent antiulcer agents derived from natural herbs, such as Artemisia asiatica (DA‐9601; Stillen ™ , Dong‐A Pharmaceuticals, Yongin, Korea), are being sold in markets based on their potent antioxidant effects (Baek et al., 2011).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

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“…The gastroprotective and antioxidant effects of quercetin and rutin are well known (La Casa et al 2000, De la Lastra et al 1994, and there are many studies showing the antiulcerogenic properties of flavonoids (Gonzalez and Di Stasi 2002). The role of reactive oxygen species in the pathogenesis of acute ethanol that induced gastric mucosal lesions and the effects of quercetin have been evaluated in a few studies.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

Rodrigues¹,

Morais²,

Souza³

et al. 2012

An. Acad. Bras. Ciênc.

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Byrsonima sericea leaves are extensively used in folk medicine in Brazil against gastric disorders. This study investigated the chemical constituents of B. sericea leaf ethanolic extract (BSLE) and its potential gastroprotective activity, with its possible mechanism of the action using ethanol to induce gastric mucosal damage in mice. The phytochemical analysis was carried out to identify the active constituents present in the extract, and the HPLC analysis was performed for the identification of flavonoids. BSLE at oral doses of 125, 250 and 500 mg/kg markedly attenuated the ethanol-evoked gastric lesions by 53.2, 84.9 and 87.6 %, respectively. The BSLE (250 mg/kg) prevented the depletion of gastric mucus and gastric mucosal nonproteic-sulfhydryl groups, SOD and CAT, as well as the increase in the MDA content promoted by absolute ethanol. Moreover, the effect of BSLE against ethanol damage was found to be significantly reduced in mice pretreated with Capsazepine (i.p.), L-NAME (i.p.) or glibenclamide (i.p.), the respective blockers/inhibitors of TRPV1, NO synthase and K+ATP channel. The phytochemical investigation on BSLE revealed the presence of flavonoids rutin, isoquercitrin, kaempferol 3-O-rutinoside and quercetin, which are compounds well known for their antioxidant and gastroprotective properties. These results suggest that BSLE affords gastroprotection through multiple mechanisms, which may be helpful in the treatment of pathologies associated with gastric dysfunctions.

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Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions

Cited by 484 publications

References 32 publications

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

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