2012
DOI: 10.1016/j.ejphar.2012.02.034
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Evidence for the involvement of the monoaminergic system, but not the opioid system in the antidepressant-like activity of ellagic acid in mice

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Cited by 82 publications
(62 citation statements)
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“…This bioflavonoid has antioxidant, antifibrotic, anti-inflammatory, cardio-protective and anti-cancer properties (24). Girish et al reported anti-depressant-like effect of ellagic acid, which is associated to its interaction with serotonergic and adrenergic system (25). Girish et al assessed anxiolytic effect of ellagic acid.…”
Section: Discussionmentioning
confidence: 99%
“…This bioflavonoid has antioxidant, antifibrotic, anti-inflammatory, cardio-protective and anti-cancer properties (24). Girish et al reported anti-depressant-like effect of ellagic acid, which is associated to its interaction with serotonergic and adrenergic system (25). Girish et al assessed anxiolytic effect of ellagic acid.…”
Section: Discussionmentioning
confidence: 99%
“…In a study ellagic acid also produces anti anxiety-like effect which was antagonized by a non-competitive GABAA receptor antagonist and a benzodiazepine site antagonist which shows modulation of GABAergic system by EA [140] . Receptorfor advanced glycation endproducts (RAGE), is a tentative cell membrane receptor for AÎČ, binds to AÎČ with high affinity [141] .…”
Section: Ellagic Acid and Depressionmentioning
confidence: 99%
“…In vitro antidepressant potential of ellagic acid was found in MAO-A inhibition assay [114] . Further, ellagic acid produce antiimmobility effect in anti-depressant models mediated through monoaminergic system (serotonergic and noradrenergic systems) [131] . Pretreatment with prazosin (an alpha-adrenoceptor antagonist) and p-CPA (serotonin synthesis inhibitor) reverse the anti depressive effect of ellagic acid where ellagic acid interacts with α-adrenoceptors and serotonergic receptors to produce anti depressive effect [128] .…”
Section: Ellagic Acid and Depressionmentioning
confidence: 99%
“…It has been demonstrated that acute oral administration of EA or extract contains EA causes modulation of monoaminergic system (serotonergic and adrenergic), and this represents the mechanism of the antidepressant activity of EA [59,60]. The intimate mechanism by which EA could manipulate the monoaminergic system has remained obscure.…”
Section: Kotob Et Almentioning
confidence: 99%