Evidence of a Recombinant Wild-Type Human Astrovirus Strain from a Kenyan Child with Gastroenteritis

Wolfaardt, Marianne; Kiulia, Nicholas M.; Mwenda, Jason M.; Taylor, Maureen B.

doi:10.1128/jcm.01093-10

Cited by 60 publications

(54 citation statements)

References 27 publications

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“…Recently, two novel Mamastrovirus 6 species (GI.F and AstV-MLB2) identified in patients displayed close genetic relatedness to urban brown rat astroviruses identified in Hong Kong [42]. Further, three novel Mamastrovirus 8 and 9 species (GII.A and GII.B) were detected in human stool samples from Nepal, Pakistan and Nigeria [16].…”

Section: Genomic Diversity Among Astrovirusesmentioning

confidence: 98%

“…Novel recombinant human astrovirus strains were first described in children with HAstV_G3 (ORF1b) and HAstV_G5 (ORF2) combination in the ORF1b/ORF2 junction [40]. Human astrovirus wild-type strain obtained from a Kenyan child showed genetic recombination event in the sequence analyses of ORF1a (HAstV_G6/7), ORF1b (HAstV_G3) and ORF2 region (HAstV_G2) [42].…”

Section: Genomic Diversity Among Astrovirusesmentioning

confidence: 99%

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Novel human astroviruses: challenges for developing countries

Krishnan

2014

VirusDis.

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Astroviruses have been gaining widespread importance over the past few decades owing to their detection through advanced molecular techniques. The association of astrovirus-associated enteric infections have been reported from various settings among different age groups. The tremendous efforts of scientists from different countries to detect and characterize these star-like viruses in the course of surveillance has shown the emergence of novel astroviruses from varied host species, necessitating changes in the classification to update their taxonomy. The public health importance of these viruses implies new control measures are essential to reduce disease burden in developing countries.

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Section: Genomic Diversity Among Astrovirusesmentioning

confidence: 98%

Section: Genomic Diversity Among Astrovirusesmentioning

confidence: 99%

Novel human astroviruses: challenges for developing countries

Krishnan

2014

VirusDis.

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“…Molecular recombination of genomic RNA can affect phylogenetic groupings, increase the virulence of the virus, confuse molecular epidemiological studies and have major implications in vaccine design (Bull et al, 2007). As seen in noroviruses, the highly conserved junction region connecting the non-structural and structural genes of HAstVs seems to be a recombination hot spot (De Grazia et al, 2012;Wolfaardt et al, 2011). On the opposite, strain ITA/2008/ BA393/08-65 in the ORF1b was more similar to type-4c strains, indicating that such ORF1b/ORF2 combination tends to be retained in this type-4 lineage.…”

Section: Discussionmentioning

confidence: 99%

Lineage diversification and recombination in type-4 human astroviruses

Martella

Medici

Terio

et al. 2013

Infection, Genetics and Evolution

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“…Recombinations between different animal AstVs have also been described (152,155,162,183). Although most recombination breakpoints have been identified upstream of the conserved ORF1b/ORF2 junction region (155,168,172,182), they are also frequent within ORF2 (152,155,172,177), and they may also exist within ORF1a (155,181) and ORF1b (155,177,180).…”

Section: Figmentioning

confidence: 99%

Human Astroviruses

2014

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SUMMARY Human astroviruses (HAtVs) are positive-sense single-stranded RNA viruses that were discovered in 1975. Astroviruses infecting other species, particularly mammalian and avian, were identified and classified into the genera Mamastrovirus and Avastrovirus . Through next-generation sequencing, many new astroviruses infecting different species, including humans, have been described, and the Astroviridae family shows a high diversity and zoonotic potential. Three divergent groups of HAstVs are recognized: the classic ( MAstV 1 ), HAstV-MLB ( MAstV 6 ), and HAstV-VA/HMO ( MAstV 8 and MAstV 9 ) groups. Classic HAstVs contain 8 serotypes and account for 2 to 9% of all acute nonbacterial gastroenteritis in children worldwide. Infections are usually self-limiting but can also spread systemically and cause severe infections in immunocompromised patients. The other groups have also been identified in children with gastroenteritis, but extraintestinal pathologies have been suggested for them as well. Classic HAstVs may be grown in cells, allowing the study of their cell cycle, which is similar to that of caliciviruses. The continuous emergence of new astroviruses with a potential zoonotic transmission highlights the need to gain insights on their biology in order to prevent future health threats. This review focuses on the basic virology, pathogenesis, host response, epidemiology, diagnostic assays, and prevention strategies for HAstVs.

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Evidence of a Recombinant Wild-Type Human Astrovirus Strain from a Kenyan Child with Gastroenteritis

Cited by 60 publications

References 27 publications

Novel human astroviruses: challenges for developing countries

Novel human astroviruses: challenges for developing countries

Lineage diversification and recombination in type-4 human astroviruses

Human Astroviruses

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