Amagat and Dalton mixing-models were analyzed to compare their thermodynamic prediction of shock states. Numerical simulations utilized the Sandra National Laboratories (SNL) shock hydrodynamic code CTH [1]. Simulations modeled the University of New Mexico (UNM) shock tube laboratory experimental series shocking a 1:1 molar mixture of helium (He) and sulfur hexafluoride (SF6). Five input parameters were varied for sensitivity analysis: driver section pressure; driver section density; test section pressure; test section density; and mixture ratio (mole fraction). We show via incremental Latin hypercube sampling (LHS) analysis that significant differences exist between Amagat and Dalton mixing-model predictions. The differences observed in predicted shock speeds, temperatures, and pressures grow more pronounced with higher shock speeds.