Evidence relating the inhibitory effect of cobalt on the activity of δ-aminolevulinate synthase to the intracellular concentration of porphyrins

Schoenfeld, Nili; Greenblat, Yehudit; Epstein, O; Tschudy, Donald P.; Atsmon, A

doi:10.1016/0006-2952(83)90182-x

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…High concentrations of cobalt promote various protein modulations, for example inhibition of delta‐aminolevulinic acid synthase , activation of arginase, and induction of acylamino acid hydrolase . Also, cobalt depletes neurotransmitters from several regions of the brains .…”

Section: Introductionmentioning

confidence: 99%

A review of metal‐catalyzed molecular damage: protection by melatonin

Romero

Ramos

Rı́os

et al. 2014

Journal of Pineal Research

158

110

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Metal exposure is associated with several toxic effects; herein, we review the toxicity mechanisms of cadmium, mercury, arsenic, lead, aluminum, chromium, iron, copper, nickel, cobalt, vanadium, and molybdenum as these processes relate to free radical generation. Free radicals can be generated in cells due to a wide variety of exogenous and endogenous processes, causing modifications in DNA bases, enhancing lipid peroxidation, and altering calcium and sulfhydryl homeostasis. Melatonin, an ubiquitous and pleiotropic molecule, exerts efficient protection against oxidative stress and ameliorates oxidative/nitrosative damage by a variety of mechanisms. Also, melatonin has a chelating property which may contribute in reducing metal-induced toxicity as we postulate here. The aim of this review was to highlight the protective role of melatonin in counteracting metal-induced free radical generation. Understanding the physicochemical insights of melatonin related to the free radical scavenging activity and the stimulation of antioxidative enzymes is of critical importance for the development of novel therapeutic strategies against the toxic action of these metals.

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Section: Introductionmentioning

confidence: 99%

A review of metal‐catalyzed molecular damage: protection by melatonin

Romero

Ramos

Rı́os

et al. 2014

Journal of Pineal Research

158

110

View full text Add to dashboard Cite

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“…As is shown in table 3 and fig.1 [O2Co(lys)2].nH20 and [O2Co(ser)2].nH20 suppress the process of irreversible adsorption of HSV-1 particles onto host cells. Thus, at the end of the adsorption period lh, up to 10% viral particles were steadily attached.…”

Section: Complexmentioning

confidence: 99%

Effect of Complexes of Cobalt With Aminoacids on the Replicationof Herpes Simplex Virus Type 1 (HSV‐1)

et al. 1996

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Cobalt, being essential metal, influences different physiological and enzymatic functions. As cobalt does not accumulate in the body, Co-compounds have relatively low toxicity. The aim of the present study is the effect of complexes of Co(II) with aminoacids - lysine, arginine, histidine and serine on HSV-1 replication. No effect of [O2Co(his)4].nH2O and [O2Co(arg)2].nH2O on HSV-1 infection in vitro was found. Both, [O2Co(lys)2].nH2O and [O2Co(ser)2].nH2O suppress the attachement of HSV-1 particles onto target cells and the viral replication as well. Moreover, the properties of the particular Co-complex (charge, stability, structure) are manifestated by their virucidal effect. Thus, [O2Co(ser)2].nH2O irreversibly inhibits the infectious activity of free HSV-1 virions, while virucidal effect of [O2Co(lys)2].nH2O is completely reversible after the 2h of contact.

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