Evidence that cagA+Helicobacter pylori strains are disappearing more rapidly than cagA- strains

Perez-Perez, Guillermo I.; Salomaa, Anniina; Kosunen, Timo U.; Daverman, B; Rautelin, Hilpi; Aromaa, Arpo; Knekt, Paul; Blaser, Martin J.

doi:10.1136/gut.50.3.295

Cited by 79 publications

(87 citation statements)

References 37 publications

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“…Based on these observation it seems that colonization of some younger subjects (< 30 years) with CagA-positive strains is a transient phenomenon. The accumulating evidence regarding CagA-positive strains are more susceptible than CagA-negative strains to eradication treatment [33] is consistent with our observation. Our result showed that the prevalence of anti-H pylori antibody was significantly higher in males compared to females.…”

Section: Discussionsupporting

confidence: 92%

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Jafarzadeh¹,

Rezayati²,

Nemati³

2007

WJG

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AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method. RESULTS:The seroprevalence of H pylori in adults was significantly higher than that observed in children (67.5% vs 46.6%; P < 0.000003). In children, the seropositivity rate in males (51.9%) was significantly (P < 0.05) higher than that observed in females (41.7%). The prevalence of serum anti-CagA antibody was 72.8% and 67.4% in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P < 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4% vs 66.3%; P = 0.07 and 75.6% vs 54.71%; P < 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6% and 59.57% at age 1-5 years, 46.9% and 75% at age 6-10 years, 54.9% and 79.45% at age 11-15, 59.01% and 83.33% at age 20-30 years, 66.6% and 60.52% at age 31-40 years, 73.46% and 63.88% at age 41-50 years and 75.75% and 60% at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P < 0.001). CONCLUSION:These results showed that anti-H pylori and anti-CagA antibodies were common in the children and adults. The H pylori -specific antibodies influenced by age and sex of subjects. Moreover, it seems that males are more susceptible to infection with CagA + strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.

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Section: Discussionsupporting

confidence: 92%

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Jafarzadeh¹,

Rezayati²,

Nemati³

2007

WJG

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“…As Hp infection persists over a lifetime, it is mandatory that both the microbe and the host adapt to each other. Once chronicity is established, the immune stimulation appears remarkably constant, as antibody titers remain stable for over 20 years (36), consistent with a model of dynamic equilibrium (37). Previous studies have shown that human bronchial mucosa explants exposed to TNF-α had an increased expression of several glycosyltransferases, namely fucosyltransferases and sialyltransferases (19).…”

Section: Discussionsupporting

confidence: 81%

Helicobacter pylori induces β3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl–Lewis x

Marcos¹,

Magalhães²,

Ferreira³

et al. 2008

J. Clin. Invest.

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“…The proportion of young children becoming infected is now extremely low, most probably due to antibiotic use [18]. Puzzlingly, there has also been a selective decline in the more virulent CagA + strains of H. pylori [19]. In opposition to this, between 1973 and 1994, Kosunen et al [20] found that markers of allergy increased by more than threefold, with the increase mainly occurring in H. pylori-negative subjects [20].…”

Section: Introductionmentioning

confidence: 99%

Exposure To Helicobacter Pylori Infection In Early Childhood And The Risk Of Allergic Disease And Atopic Sensitization: A Longitudinal Birth Cohort Study

Amberbir¹,

Medhin²,

Abegaz³

et al. 2012

D26. Pediatric Respiratory Infections

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SummaryBackground An inverse relation between Helicobacter pylori infection and allergic disease has been reported by a range of independent epidemiological studies, but evidence from longitudinal studies is scarce. Objective We have investigated the effects of H. pylori infection on the incidence and prevalence of allergic diseases and sensitization in a low-income birth cohort. Methods In 2005/2006, a population-based birth cohort was established in Butajira, Ethiopia, and the 1006 singleton babies born were followed up at ages 1, 3, and 5. Symptoms of allergic disease were collected using the ISAAC questionnaire, allergen skin tests performed, and stool samples analysed for H. pylori antigen and geohelminths. Multiple logistic regression was used to determine the independent effects of H. pylori measured at age 3 on the incidence of each outcome between ages 3 and 5 years (in those without the outcome at age 3), controlling for potential confounders, and to additionally assess crosssectional associations. Results A total of 863 children were followed up to age 5. H. pylori infection was found in 25% of the children at both ages 3 and 5, in 21% at age 5 but not 3, and in 17% at age 3 but not at age 5. H. pylori infection at age 3 was significantly associated with a decreased risk of incident eczema between ages 3 and 5 (adjusted OR, 95% CI, 0.31; 0.10-0.94, P = 0.02). Cross-sectionally at age 5, H. pylori infection was inversely associated with skin sensitization (adjusted OR, 95% CI, 0.26; 0.07-0.92, P = 0.02). Conclusion and clinical relevance These findings provide further evidence to suggest that early-life exposure to H. pylori may play a protective role in the development of allergy.

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Evidence that cagA+Helicobacter pylori strains are disappearing more rapidly than cagA- strains

Cited by 79 publications

References 37 publications

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Helicobacter pylori induces β3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl–Lewis x

Exposure To Helicobacter Pylori Infection In Early Childhood And The Risk Of Allergic Disease And Atopic Sensitization: A Longitudinal Birth Cohort Study

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