Evolution of Resistance in the Presence of Two Insecticides

Mani, G.S.

doi:10.1093/genetics/109.4.761

Cited by 141 publications

(45 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The superiority of Combination over the other strategies appears to be very robust: in most models, this approach was effective for longer even if input and output parameters were varied. Its comparative advantage is particularly high when: (1) resistance to each pesticide or drug is initially rare [1721], (2) resistance to each pesticide or drug in the combination are controlled by independent loci (no crossresistance) [17,2224], (3) there is a high rate of recombination between the loci [17,20,23,24], (4) in diploids, homozygous susceptible individuals have a high mortality [15,21], (5) in diploids, resistance to each pesticide is…”

Section: Theoretical Comparisons Between Strategiesmentioning

confidence: 99%

“…Comment citer ce document : REX Consortium, Bourguet, D. (Auteur de correspondance), Delmotte, F., Franck, P., Guillemaud [17,23,2527], (6) the pesticides or drugs are of similar persistence [15,27] and (7) some of the population remains untreated [20,22,24,25]. Even if these conditions are not completely met, Combination appears at least as good as the three other strategies.…”

Section: Version Postprintmentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity of selection and the evolution of resistance

Bourguet

Delmotte²,

Franck

et al. 2013

Trends in Ecology & Evolution

191

140

View full text Add to dashboard Cite

The evolution of resistance to pesticides and drugs by pests and pathogens is a textbook example of adaptation to environmental changes and a major issue in both public health and agronomy. Surprisingly, there is little consensus on how to combine selection pressures (i.e., molecules used in the treatment of pests or pathogens) over space and time to delay or prevent this evolutionary process. By reviewing theoretical models and experimental studies, we show that higher levels of heterogeneity of selection are associated with longer-term sustainability of pest or pathogen control. The combination of molecules usually outcompetes other resistance management strategies, such as Responsive alternation, Periodic application, or Mosaic, because it ensures 'multiple intragenerational killing'. A strategic deployment over space and/or time of several combinations can ensure 'multiple intergenerational killing', further delaying the evolution of resistance.

show abstract

Section: Theoretical Comparisons Between Strategiesmentioning

confidence: 99%

Section: Version Postprintmentioning

confidence: 99%

Heterogeneity of selection and the evolution of resistance

Bourguet

Delmotte²,

Franck

et al. 2013

Trends in Ecology & Evolution

191

140

View full text Add to dashboard Cite

show abstract

“…At the level of changes in frequency of the resistance allele, the models were checked against similar models (e.g. Mani 1985;Mallet & Porter 1992;Tabashnik 1994b) and gave the same results for the same parameter values. The model also tracks population density on both transgenic and non-transgenic host plants.…”

Section: (B) Modelling Formatmentioning

confidence: 99%

Two–toxin strategies for management of insecticidal transgenic crops: can pyramiding succeed where pesticide mixtures have not?

Roush

1998

Phil. Trans. R. Soc. Lond. B

396

370

View full text Add to dashboard Cite

Transgenic insect-resistant crops that express toxins from Bacillus thuringiensis (Bt) o¡er signi¢cant advantages to pest management, but are at risk of losing these advantages to the evolution of resistance in the targeted insect pests. All commercially available cultivars of these crops carry only a single Bt gene, and are particularly at risk where the targeted insect pests are not highly sensitive to the Bt toxin used. Under such circumstances, the most prudent method of avoiding resistance is to ensure that a large proportion of the pest population develops on non-transgenic`refuge' hosts, generally of the crop itself. This has generated recommendations that 20% or more of the cotton and maize in any given area should be nontransgenic. This may be costly in terms of yields and may encourage further reliance on and resistance to pesticides. The use of two or more toxins in the same variety (pyramiding) can reduce the amount of refuge required to delay resistance for an extended period. Cross-resistance among the toxins appears to have been overestimated as a potential risk to the use of pyramids (and pesticide mixtures) because crossresistance is at least as important when toxicants are used independently. Far more critical is that there should be nearly 100% mortality of susceptible insects on the transgenic crops. The past failures of pesticide mixtures to manage resistance provide important lessons for the most e¤cacious deployment of multiple toxins in transgenic crops.

show abstract

“…Thus, mixtures of decaying and freshly applied residues with unpredictable selective e¡ects would exist for long periods. In fact, however, mixtures of appropriate dosages of unrelated compounds may have better prospects of managing resistance e¡ectively than do rotations (Mani 1985;Curtis et al 1993;Barnes et al 1995). Carefully chosen mixtures of several antibiotics (with directly observed consumption of the drugs to ensure patient compliance and meticulous hygienic practices) are recognized as the only way to control multi-drug resistance in outbreaks of tuberculosis, leprosy and other bacterial diseases.…”

Section: Possible Use Of Non-pyrethroids To Manage Pyrethroid Resistance In Anophelesmentioning

confidence: 99%

Can anything be done to maintain the effectiveness of pyrethroid–impregnated bednets against malaria vectors?

Curtis

Miller

Hodjati

et al. 1998

Phil. Trans. R. Soc. Lond. B

View full text Add to dashboard Cite

Pyrethroid-treated bednets are the most promising available method of controlling malaria in the tropical world. Every e¡ort should be made to ¢nd methods of responding to, or preventing, the emergence of pyrethroid resistance in the Anopheles vectors. Some cases of such resistance are known, notably in An. gambiae in West Africa where the kdr type of resistance has been selected, probably because of the use of pyrethroids on cotton. Because pyrethroids are irritant to mosquitoes, laboratory studies on the impact of, and selection for, resistance need to be conducted with free-£ying mosquitoes in conditions that are as realistic as possible. Such studies are beginning to suggest that, although there is cross-resistance to all pyrethroids, some treatments are less likely to select for resistance than others are. Organophosphate, carbamate and phenyl pyrazole insecticides have been tested as alternative treatments for nets or curtains. Attempts have been made to mix an insect growth regulator and a pyrethroid on netting to sterilize pyrethroid-resistant mosquitoes that are not killed after contact with the netting. There seems to be no easy solution to the problem of pyrethroid resistance management, but further research is urgently needed.

show abstract

Evolution of Resistance in the Presence of Two Insecticides

Cited by 141 publications

References 6 publications

Heterogeneity of selection and the evolution of resistance

Heterogeneity of selection and the evolution of resistance

Two–toxin strategies for management of insecticidal transgenic crops: can pyramiding succeed where pesticide mixtures have not?

Can anything be done to maintain the effectiveness of pyrethroid–impregnated bednets against malaria vectors?

Contact Info

Product

Resources

About