Evolution of the Anticonvulsant Activity of α-Terpineol

Abstract

a-Terpineol, a monoterpenoid alcohol, was investigated for its anticonvulsant activity. This compound increased the latency to convulsions induced by pentylenetetrazole at doses of 100 and 200 mg=kg and decreased the incidence of hindlimb extension produced by MES in a dose-related manner at doses of 200 and 400 mg=kg.

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

“…Thus, our results are in agreement with previous studies that indicate increased oxidative stress during brain disorders Ferreira et al, 2009), but they contrast with assays that show increased oxidative stress and decreased antioxidant defense during anticonvulsant therapy (Ono et al, 2000;Vinson et al, 2001;De Sousa et al, 2007).…”

“…The results obtained and the LD 50 (~1.732 ± 0.1 g/kg) value represent a relative low toxicity from EO of C. limon, which was particularly related to their possible CNS depressor properties. In spite of the knowledge that EO constitution of monoterpenes are often considered to have low toxicity (Tanaka et al, 1996;De Sousa et al, 2007), we assume that additional studies are recommended to further ascertain the safety of EO of C. limon use.…”

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

“…Essential oils are natural products generally obtained from medicinal plants that exhibit a variety of biological properties, such as analgesic (Almeida et al, 2001), anticonvulsant (De Sousa et al, 2007;QuintansJúnior et al, 2008a), anxiolytic and hypnotic . Monoterpenes are the main components of these essential oils and the pharmacological properties of many medicinal plants have been attributed to them (Peana et al, 2004;De Sousa et al, 2006;De Sousa et al, 2007;Melo et al, 2010).…”

“…Monoterpenes are the main components of these essential oils and the pharmacological properties of many medicinal plants have been attributed to them (Peana et al, 2004;De Sousa et al, 2006;De Sousa et al, 2007;Melo et al, 2010).…”

Antinociceptive effect of citronellal in mice

“…They are found in edible as well as medicinal plants with a therapeutic property (Carneiro et al, 1997). Additionally, monoterpenes and their derivative compounds exhibit several types of pharmacological properties, such as anxiolytic (Silva et al, 2007), antinociceptive (De Sousa et al, 2007b), sedative (Elisabetsky et al, 1995;De Sousa et al, 2006a, 2007a, antidepressant (De Sousa et al, 2006b), and anticonvulsant (Viana et al, 2000;De Sousa et al, 2006c, 2007c. In this regard, citronellal (3,7-dimethyl-6-octen-1-al) as a monoterpene is a major component of the essential oils in various aromatic species, such as Cymbopogon winterianus Jowitt (Java citronella) (Quintans-Júnior et al, 2008), Corymbia citriodora (Hook.)…”