The selection of the optimal variety show hosts is a key to television stations. However, no study has a deal with this issue. In this paper, a hybrid multiple criteria decision-making (MCDM) model based on the fuzzy Delphi method, decision-making trial and evaluation laboratory (DEMATEL), analytic network process (ANP), and technique for order preference by similarity to ideal solution (TOPSIS) to choose optimal hosts of variety shows for television stations in the social media era was developed. The fuzzy Delphi method was taken as a screening tool for the selection criteria of variety show hosts. Then, DEMATEL was applied to verify the interdependencies between the perspectives. According to the interdependencies, ANP was employed to obtain weights. Finally, TOPSIS ranked the alternatives. The selection criteria were gathered from previous researches and discussions with senior executives of television stations. By the fuzzy Delphi method, 12 criteria were identified. Based on the past study and consultations with four senior executives, we classified 12 essential criteria into four perspectives to develop the hierarchy for the variety show host selection. Under the hierarchy base on four perspectives and 12 criteria, managers of television stations could select the optimal variety show hosts more effectively. The usability and efficiency of the proposed model were also considered by a case study. We offered a distinct contribution to the prior studies by providing a model in the variety show host selection field. In the context of social media competition, this study also added the selection criteria from Internet celebrities.