Ex Vivo Estimation of Photoacoustic Imaging for Detecting Thyroid Microcalcifications

Kang, Jeeun; Chung, Woong Youn; Kang, Sang Wook; Kwon, Hyeong Ju; Yoo, Jeong Seon; Kim, Min Jung; Chang, Jin Ho; Song, Tai-Kyong; Lee, Sohee; Kwak, Jin Young

doi:10.1371/journal.pone.0113358

Cited by 15 publications

(10 citation statements)

References 29 publications

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“…Kang et al have utilized a 5–14 MHz linear array transducer to study thyroid microcalcifications on resected human thyroid nodules [50]. PAI was compared with radiographs that were obtained immediately after surgery, ultrasonography images, visual inspection and histologic analyses of the resected tissue.…”

Section: Thyroid Imagingmentioning

confidence: 99%

Photoacoustic clinical imaging

et al. 2019

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Photoacoustic is an emerging biomedical imaging modality, which allows imaging optical absorbers in the tissue by acoustic detectors (light in - sound out). Such a technique has an immense potential for clinical translation since it allows high resolution, sufficient imaging depth, with diverse endogenous and exogenous contrast, and is free from ionizing radiation. In recent years, tremendous developments in both the instrumentation and imaging agents have been achieved. These opened avenues for clinical imaging of various sites allowed applications such as brain functional imaging, breast cancer screening, diagnosis of psoriasis and skin lesions, biopsy and surgery guidance, the guidance of tumor therapies at the reproductive and urological systems, as well as imaging tumor metastases at the sentinel lymph nodes. Here we survey the various clinical and pre-clinical literature and discuss the potential applications and hurdles that still need to be overcome.

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Section: Thyroid Imagingmentioning

confidence: 99%

Photoacoustic clinical imaging

et al. 2019

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“…Most developed handheld PAI probes employ an optical fiber or optical fiber bundles attached to the side of the ultrasound transducer for light beam delivery. [7][8][9][10][11][12] The probes have the merits of low transmission losses of light and sound, because they do not use any combiner so that a probe with the structure can receive the largest photoacoustic signal as a function of the light intensity. 13 However, the detectable imaging region depends on the angle of incident light and there is an undetectable zone, called dark-field illumination, because the illuminated light beam is oblique with respect to the acoustic beam, and the image is obtained in the intersecting region between the illuminating light beam and receiving acoustic beam.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic imaging probe for detecting lymph nodes and spreading of cancer at various depths

et al. 2017

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We propose a compact and easy to use photoacoustic imaging (PAI) probe structure using a single strand of optical fiber and a beam combiner doubly reflecting acoustic waves for convenient detection of lymph nodes and cancers. Conventional PAI probes have difficulty detecting lymph nodes just beneath the skin or simultaneously investigating lymph nodes located in shallow as well as deep regions from skin without any supplementary material because the light and acoustic beams are intersecting obliquely in the probe. To overcome the limitations and improve their convenience, we propose a probe structure in which the illuminated light beam axis coincides with the axis of the ultrasound. The developed PAI probe was able to simultaneously achieve a wide range of images positioned from shallow to deep regions without the use of any supplementary material. Moreover, the proposed probe had low transmission losses for the light and acoustic beams. Therefore, the proposed PAI probe will be useful to easily detect lymph nodes and cancers in real clinical fields.

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“…The configuration can construct the hybrid imaging mode between ultrasound and PA images so that the anatomic and molecular information can both be provided. Using the configuration, various applications are being researched; sentinel lymph node detection for screening cancer metastasis 4 , breast microcalcifications detection for early-detection of breast cancer 5 -7 , tissue characterization for thyroid and ovarian tumor lesion 8,9 , etc. The imaging dimension can be further extended using tomographic configuration.…”

Section: Introductionmentioning

confidence: 99%

Toward high-speed transcranial photoacoustic imaging using compact near-infrared pulsed LED illumination system

Kang

Zhang

Rahmim

et al. 2017

Photons Plus Ultrasound: Imaging and Sensing 2017

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Quantification of brain function is a significant milestone towards understanding of the underlying workings of the brain. Photoacoustic (PA) imaging is the emerging brain sensing modality by which the molecular light absorptive contrast can be non-invasively quantified from deep-lying tissue (~several cm). In this BRAIN initiative effort, we propose highspeed transcranial PA imaging using a novel, compact pulsed LED illumination system (Prexion Inc., Japan) with 200-uJ pulse energy for 75-ns duration, and pulse repetition frequency (PRF) up to 4kHz at near-infrared (NIR) wavelengths of 690-nm and 850-nm switchable in real-time. To validate the efficacy of the proposed system, preliminary ex vivo experiments were conducted with mice skull and human temporal bone, which included vessel-mimicking tubes filled with 10% Indian Ink solution and light absorptive rubber material, respectively. The results indicated that significant PA contrast, 150% signal-to-noise ratio (SNR), can be achieved through the mice skull only with 64 subsequent frame averaging. The minimal number of frames for averaging required was only 16 to generate signal above background noise, leading to 250 Hz frame rate in the strictest temporal frame separation. Furthermore, distinguishable PA contrast was achieved with human temporal bone with 64-frame averaging. Overall, the preliminary results indicate that the LED illumination system can be a cost-effective solution for high-speed PA brain imaging in preclinical and clinical applications, compared to expansive and bulky Nd:YAG laser systems commonly used in PA imaging.

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Ex Vivo Estimation of Photoacoustic Imaging for Detecting Thyroid Microcalcifications

Cited by 15 publications

References 29 publications

Photoacoustic clinical imaging

Photoacoustic clinical imaging

Photoacoustic imaging probe for detecting lymph nodes and spreading of cancer at various depths

Toward high-speed transcranial photoacoustic imaging using compact near-infrared pulsed LED illumination system

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