Examining Safety of Biocolourants from Fungal and Plant Sources-Examples from Cortinarius and Tapinella, Salix and Tanacetum spp. and Dyed Woollen Fabrics

Räisänen, Riikka; Primetta, Anja; Nikunen, Sari; Honkalampi, Ulla; Nygrén, Heli; Pihlava, Juha Matti; Berghe, Ina Vanden

doi:10.3390/antibiotics9050266

Cited by 19 publications

(12 citation statements)

References 86 publications

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“…2 NOESY and HMBC key correlations observed for compounds 1 and 2 malicoria-pigmentation-type, characterized by the presence of pre-AQs [e.g., flavomannin-6,6′-dimethyl ether (6)], AQ carboxylic acids [e.g., dermolutein (4) and dermorubin (5)], as well as the monomeric AQ emodin (7) and its glucoside (3). Looking at the results of our secondary metabolite investigation and thus from a chemotaxonomic point of view, the phylogenetic classification of C. rubrophyllus can be confirmed, as its pigment profile matches the profiles of both C. semisanguineus [22][23][24] and C. malicorius [15].…”

Section: Isolation and Identification Of Isolated Secondary Metabolitesmentioning

confidence: 79%

Optimized isolation of 7,7′-biphyscion starting from Cortinarius rubrophyllus, a chemically unexplored fungal species rich in photosensitizers

Hammerle

Steger

Zhou

et al. 2021

Photochem Photobiol Sci

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Mushrooms such as the dermocyboid Cortinarius rubrophyllus are characterized by strikingly colorful fruiting bodies. The molecular dyes responsible for such colors recently experienced a comeback as photoactive compounds with remarkable photophysical and photobiological properties. One of them—7,7′-biphyscion—is a dimeric anthraquinone that showed promising anticancer effects in the low nanomolar range under blue-light irradiation. Compared to acidic anthraquinones, 7,7′-biphyscion was more efficiently taken up by cells and induced apoptosis after photoactivation. However, seasonal collection of mushrooms producing this compound, low extraction yields, and tricky fungal identification hamper further developments to the clinics. To bypass these limitations, we demonstrate here an alternative approach utilizing a precursor of 7,7′-biphyscion, i.e., the pre-anthraquinone flavomannin-6,6′-dimethyl ether, which is abundant in many species of the subgenus Dermocybe. Controlled oxidation of the crude extract significantly increased the yield of 7,7′-biphyscion by 100%, which eased the isolation process. We also present the mycochemical and photobiological characterization of the yet chemically undescribed species, i.e. C. rubrophyllus. In total, eight pigments (1–8) were isolated, including two new glycosylated anthraquinones (1 and 2). Light-dependent generation of singlet oxygen was detected for the first time for emodin-1-O-β-d-glucopyranoside (3) [photophysical measurement: Φ∆ = 0.11 (CD3OD)]. Furthermore, emodin (7) was characterized as promising compound in the photocytotoxicity assay with EC50-values in the low micromolar range under irradiation against cells of the cancer cell lines AGS, A549, and T24. Graphical abstract

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Section: Isolation and Identification Of Isolated Secondary Metabolitesmentioning

confidence: 79%

Optimized isolation of 7,7′-biphyscion starting from Cortinarius rubrophyllus, a chemically unexplored fungal species rich in photosensitizers

Hammerle

Steger

Zhou

et al. 2021

Photochem Photobiol Sci

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“…Klaus et al investigated different extracts of L. sulphureus fruiting body and concluded that it could be applied as a food colorant, as no cytotoxic effects were provable [5]. Even though L. sulphureus fruiting bodies are edible at a young stage, and different sources state that mycelial extracts should therefore be generally recognized as safe (GRAS), the natural origin of fungal dyes does not automatically imply food safety [32]. Further studies on the safety profile of the dyed goods appear mandatory.…”

Section: Discussionmentioning

confidence: 99%

Pilot-Scale Production of the Natural Colorant Laetiporic Acid, Its Stability and Potential Applications

et al. 2022

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Laetiporus sulphureus, a wood-decaying basidiomycete, produces yellow-orange pigments in fruiting bodies and, as was recently shown, in submerged cultivated mycelia. Out of four strains, the most potent laetiporic acid producer was identified and its yield compared in different media. The complex Moser b medium was replaced by potato dextrose broth, achieving higher yields at a lower cost. Cultivation was then scaled up from shake flask to a 7 L stirred tank bioreactor. Optimization of parameters led to increased product concentrations up to 1 g L−1, the highest yield reported so far. An in situ product recovery strategy with a biphasic system was established, increasing the yield by 19% on the shake flask scale. A crude ethanolic extract of the biomass was examined for color stability and application trials. In contrast to what has been suggested in the past, the pigment showed limited long-term stability to oxygen and light, but was stable under storage in the dark at 4 °C under nitrogen. The orange extract was successfully incorporated into different matrices like foods, cosmetics and textiles. Laetiporic acid can potentially replace petrochemical based synthetic dyes, and can thus support the development of a circular bioeconomy.

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“…There is a growing need to develop environmentally friendly techniques, and biosynthesis of indigo is one of them. 38 − 40 The use of bioindigo could perhaps be better for the environment; because of its biodegradability and low toxicity, bioindigo has gained popularity. When we compare microorganism-produced dyes to plant-based dyes, we see that the range of natural dyes is rather limited.…”

Section: Greener Way To Produce Denimmentioning

confidence: 99%

Critical Review on Sustainability in Denim: A Step toward Sustainable Production and Consumption of Denim

Periyasamy

Periyasami

2023

ACS Omega

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The exponential development in knowledge on the health and environmental concerns linked to conventional denim processing is directly responsible for the continuous increase in demand for the exploitation of sustainable denim. Research is essential to explore alternative methods to reduce the environmental impact caused by these industries. This review examines the many sustainable ways to produce denim, keeping in mind the problems that the denim industry is now facing in finding alternatives to conventional manufacturing practices. The most current advancements in environmentally friendly dyeing techniques for denim have been extensively discussed. These processes include the production of indigo from bacteria as well as different dyeing processes, such as digital spray, microbially assisted dyeing, and foam dyeing denim with indigo. In addition, this review covers the many environmentally friendly finishing methods for denim garments, such as ozone fading, e-flow, enzyme-based bleaching, water, laser fading, and so on. Finally, it is described how the chemical and mechanical processes used to finish denim might affect the amount of microplastics and microfibers released from the denim garment during domestic washing. As a result, the content presented in this review aims to address the importance of sustainable denim processing, that is, something that can be rethought, reevaluated, renewed, and restructured within the scope of conventional denim processes, while taking eco-responsible solutions for increased environmental sustainability into account.

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Examining Safety of Biocolourants from Fungal and Plant Sources-Examples from Cortinarius and Tapinella, Salix and Tanacetum spp. and Dyed Woollen Fabrics

Cited by 19 publications

References 86 publications

Optimized isolation of 7,7′-biphyscion starting from Cortinarius rubrophyllus, a chemically unexplored fungal species rich in photosensitizers

Optimized isolation of 7,7′-biphyscion starting from Cortinarius rubrophyllus, a chemically unexplored fungal species rich in photosensitizers

Pilot-Scale Production of the Natural Colorant Laetiporic Acid, Its Stability and Potential Applications

Critical Review on Sustainability in Denim: A Step toward Sustainable Production and Consumption of Denim

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