Ethiopia has embarked on one of the largest digitalization programs for rural land registration in Africa. The program is called the national rural land administration information system (NRLAIS). Over the past couple of years, NRLAIS was rolled-out and made operational in over 180 woredas (districts). There is, however, limited empirical evidence on whether and to what extent NRLAIS has been successful. This study explores the factors that influence the acceptance and actual use of NRLAIS to gauge its operational success in Ethiopia. Data were collected both from primary and secondary sources using surveys, key informant interviews, and a literature review. Survey data were collected from 201 staff of 50 woreda land administration offices in three regional states (Amhara, Oromia, and SNNP) and analyzed using a structural equation model. The results revealed that system quality, information quality, service quality, and perceived usefulness of NRLAIS have positively and significantly influenced the acceptance and actual use of the system. However, perceived ease of use has an insignificant influence. The predictive relevance of the research model is significant and indicates substantial operational success of NRLAIS. The quick acceptance and use of NRLAIS will likely improve service delivery, promote data integration, and strengthen informed decision-making. The study recommends strengthening behavioral changes of the land administration experts through two enhanced service quality measures—technical and operational capacity to a robust and sustainable digitalization. Policymakers could leverage operational success to upgrade the NRLAIS into a unified national land registration information system that bridges the urban–rural land governance divide.