Excessive use of enrofloxacin leads to growth inhibition of juvenile giant freshwater prawn Macrobrachium rosenbergii

Zhang, Yingying; Wang, Liufu; Zhuang, Hang; Li, Xixi; Gao, Xiaojian; An, Zhenhua; Liu, Xiaodan; Yang, Hui; Wei, Wenzhi; Zhang, Xiaojun

doi:10.1016/j.ecoenv.2018.11.042

Cited by 48 publications

(13 citation statements)

References 31 publications

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“…In the present study, the zootechnical performance of the interval feeding group was superior to that of the continuous feeding group, with the best results obtained for the two-week interval feeding group. Similar results were also obtained in blunt snout bream fed with emodin using different feeding patterns (Zhang, Wang, & Zhuang, 2018). This result might be explained by the immunosuppression caused by the continuous intake of immunopotentiators.…”

Section: Discussionsupporting

confidence: 82%

Effects of dietary tea tree (Melaleuca alternifolia) oil and feeding patterns on the zootechnical performance and nonspecific immune response of the giant freshwater prawn (Macrobrachium rosenbergii)

Sun

et al. 2021

J World Aquaculture Soc

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This study investigated the effects of dietary tea tree oil (TTO) supplementation and feeding patterns on the growth and nonspecific immunity of Macrobrachium rosenbergii.Prawns were randomly assigned into four patterns. Patterns 1 (P1) and 4 (P4): prawns were fed with a basal diet and basal diet supplemented with 100 mg/kg of TTO, respectively; Patterns 2 (P2) and 3 (P3): prawns were fed with the basal diet supplemented with 100 mg/kg of TTO at 1-and 2-week intervals, respectively. A significant increase in growth performance was observed in the P3 and P4 compared with P1. The activities of antioxidant enzyme were significantly elevated in the P3 and P4 compared with the P1. The concentration of haemolymph malondialdehyde was significantly lower in the P3 and P4 than the P1. The haemolymph level of IL-1 and TNF-α was significantly lower in the P3 than the P4. The expression of toll and dorsal was significantly lower in the P3 than the P1. However, the

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Section: Discussionsupporting

confidence: 82%

Effects of dietary tea tree (Melaleuca alternifolia) oil and feeding patterns on the zootechnical performance and nonspecific immune response of the giant freshwater prawn (Macrobrachium rosenbergii)

Sun

et al. 2021

J World Aquaculture Soc

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“…The analysis confirmed that enrofloxacin at the high doses to which the shrimp were exposed caused stunted animal growth, gill and liver damage, and the induction of hepatopancreatic cell apoptosis. Moreover, the induction of oxidative stress by enrofloxacin is believed to be a likely cause of this phenomenon [ 157 ]. Interestingly, a safety analysis of this antibiotic on anuran amphibian larvae showed that the environmental concentration of enrofloxacin (10 µg/L) affected the development, size, shape, and growth of larvae, as well as inhibiting the activity of antioxidant enzymes [ 155 ].…”

Section: The Safety Of Enrofloxacin Usementioning

confidence: 99%

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

Grabowski

Gaffke

Pierzynowska

et al. 2022

IJMS

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Enrofloxacin is a compound that originates from a group of fluoroquinolones that is widely used in veterinary medicine as an antibacterial agent (this antibiotic is not approved for use as a drug in humans). It reveals strong antibiotic activity against both Gram-positive and Gram-negative bacteria, mainly due to the inhibition of bacterial gyrase and topoisomerase IV enzymatic actions. The high efficacy of this molecule has been demonstrated in the treatment of various animals on farms and other locations. However, the use of enrofloxacin causes severe adverse effects, including skeletal, reproductive, immune, and digestive disorders. In this review article, we present in detail and discuss the advantageous and disadvantageous properties of enrofloxacin, showing the benefits and risks of the use of this compound in veterinary medicine. Animal health and the environmental effects of this stable antibiotic (with half-life as long as 3–9 years in various natural environments) are analyzed, as are the interesting properties of this molecule that are expressed when present in complexes with metals. Recommendations for further research on enrofloxacin are also proposed.

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“…The giant freshwater prawn, Macrobrachium rosenbergii , is a member of arthropods, belonging to genus Macrobrachium , which is the largest freshwater and the most favored prawn for aquaculture in tropical and subtropical areas of the world [ 1 , 2 , 3 ], with annual yields of 290,708 metric tons [ 4 ]. M. rosenbergii has already been developed into an important economically aquaculture species in China [ 5 , 6 , 7 , 8 ]. The outbreaks of bacterial diseases in M. rosenbergii aquaculture have been reported, such as muscle necrosis disease caused by Enterococcus or Pseudomonas aeruginosa [ 9 , 10 , 11 ], Aeromonas species ( A. veronii and A. caviae ) and Vibrio species ( V. alginolyticus and V. parahaemolyticus ) [ 12 , 13 ] caused high-mortality diseases.…”

Section: Introductionmentioning

confidence: 99%

A Novel Disease (Water Bubble Disease) of the Giant Freshwater Prawn Macrobrachium rosenbergii Caused by Citrobacter freundii: Antibiotic Treatment and Effects on the Antioxidant Enzyme Activity and Immune Responses

et al. 2022

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The giant freshwater prawn, Macrobrachium rosenbergii, is an important and economical aquaculture species widely farmed in tropical and subtropical areas of the world. A new disease, “water bubble disease (WBD)”, has emerged and resulted in a large loss of M. rosenbergii cultured in China. A water bubble with a diameter of about 7 mm under the carapace represents the main clinical sign of diseased prawns. In the present study, Citrobacter freundii was isolated and identified from the water bubble. The optimum temperature, pH, and salinity of the C. freundii were 32 °C, 6, and 1%, respectively. A challenging experiment showed that C. freundii caused the same typical signs of WBD in prawns. Median lethal dose of the C. freundii to prawn was 104.94 CFU/g. According to the antibiogram tests of C. freundii, florfenicol and ofloxacin were selected to evaluate their therapeutic effects against C. freundii in prawn. After the challenge with C. freundii, 86.67% and 72.22% survival of protective effects against C. freundii were evaluated in the oral florfenicol pellets and oral ofloxacin pellets feding prawns, respectively, whereas the mortality of prawns without fed antibiotics was 93%. After antibiotic treatment and C. freundii infection, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), malondialdehyde (MDA), acid phosphatase (ACP), alkaline phosphatase (ALP), and lysozyme (LZM) in the hemolymph and hepatopancreas of the prawns and the immune-related gene expression levels of Cu/Zn-SOD, CAT, GPx, GST, LZM, ACP, anti-lipopolysaccharide factor, crustin, cyclophilin A, and C-type lectin in hepatopancreas were all significantly changed, indicating that innate immune responses were induced by C. freundii. These results can be beneficial for the prevention and control of C. freundii in prawns.

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Excessive use of enrofloxacin leads to growth inhibition of juvenile giant freshwater prawn Macrobrachium rosenbergii

Cited by 48 publications

References 31 publications

Effects of dietary tea tree (Melaleuca alternifolia) oil and feeding patterns on the zootechnical performance and nonspecific immune response of the giant freshwater prawn (Macrobrachium rosenbergii)

Effects of dietary tea tree (Melaleuca alternifolia) oil and feeding patterns on the zootechnical performance and nonspecific immune response of the giant freshwater prawn (Macrobrachium rosenbergii)

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

A Novel Disease (Water Bubble Disease) of the Giant Freshwater Prawn Macrobrachium rosenbergii Caused by Citrobacter freundii: Antibiotic Treatment and Effects on the Antioxidant Enzyme Activity and Immune Responses

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