Excised human larynx in N-vinyl-2-pyrrolidone-embalmed cadavers can produce voiced sound by pliable vocal fold vibration

Miyamoto, Makoto; Nagase, Miki; Watanabe, Itaru; Nakagawa, Hideki; Karita, Kanae; Tsuji, Domingos Hiroshi; Montagnoli, Arlindo Neto; Matsumura, George; Saito, Koichiro

doi:10.1007/s12565-021-00646-3

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Additionally, the velocity of airflow through excised larynx and vocal fold vibrations were equivalent to living humans, resulting in voiced sounds produced by NVP-embalmed larynges [18].…”

Section: N-vinyl-2-pyrrolidone Methodsmentioning

confidence: 99%

Cadaver preserving methods – is it possible to do anything better?

Mrożek¹,

Sędzik²,

Rubin³

et al. 2022

Medical Journal of Cell Biology

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It is impossible to imagine learning anatomy without properly fixating cadavers. Thanks to accurate preservation techniques, students can differentiate anatomical structures by their sight and touch. The formalin method was first described almost 150 years ago, and as such it may seem primitive, however it is effective and easy to use, which is why it is still in use today. Despite formaldehyde’s bactericidal, fungicidal, and insecticidal properties contact with vapors of embalming solutions such as formalin may have a negative health effect. Skin drying, eczema, allergic contact dermatitis and lowered red blood cells (RBCs) and platelets are only a few symptoms that may occur as a result of spending long periods of time in places where cadavers are stored. Due to formalin’s features, other techniques were invented. Thiel’s method is also well known; after liquid application, tissues remain their natural color as the method is non-irritating and almost odorless. With the rise of technology, more modern methods of cadaver preservation were developed as alternative to formalin, such as the use of N-vinyl-2-pyrrolidone (NVP), which is commonly implemented in Japan and Brazil, and the Modified Larssen solution (MLS), which gives the possibility to reduce formalin concentration without losing the effectiveness of tissue preservation. The aim of this work is to develop an integrated approach to cadaver preservation through the analysis of frequently used preservation techniques. This is a considerable issue because first-year students of medicine and related faculties encounter the preserved material while learning anatomy. In comparison to more modern methods, formalin seems to be the worst choice due to worse joint flexibility, tissue colour and structure and, most importantly, its cancerogenic action.

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“…Additionally, the velocity of airflow through excised larynx and vocal fold vibrations were equivalent to living humans, resulting in voiced sounds produced by NVP-embalmed larynges [18].…”

Section: N-vinyl-2-pyrrolidone Methodsmentioning

confidence: 99%

Cadaver preserving methods – is it possible to do anything better?

Mrożek¹,

Sędzik²,

Rubin³

et al. 2022

Medical Journal of Cell Biology

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show abstract

“…The use of NPV allowed for an extended preservation duration of up to 11 months (28). In another study, in cadavers embalmed with NVP, regular vibrations of the vocal folds using NVP-embalmed larynges, successfully created voiced sounds during experimental phonation (29). N-vinyl-2-pyrrolidone has a number of disadvantages.…”

Section: N-vinyl-2-pyrrolidone (Nvp) Embalmingmentioning

confidence: 99%

Innovative Cadaver Preservation Techniques: a Systematic Review

Kaliappan

Motwani

Gupta

et al. 2023

Maedica

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Cadaveric dissection is a unique and unrivalled educational tool that allows students in medicine and associated life sciences to explore spatial three-dimensional anatomy, principles of structure and related function, and anatomical variations, including pathological alterations. Human tissue dissection enables researchers to comprehend the variety that exists in life that cannot be appreciated through the literature or artificial specimens. Using cadavers is the best way to simulate surgical and anatomical teaching. A cadaver has been shown to imitate surgical and anatomical training better than any other existing method. By the use of soft embalming approaches, cadavers have become more realistic and training-friendly. The main aim of this review is to describe various innovative and recent cadaver preservation techniques in detail, which can help anatomists to modify the techniques in their institute for gross anatomy teaching and surgical training or workshops to get a lifelike cadaver.

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Formalin-free soft embalming of human cadavers using N-vinyl-2-pyrrolidone: perspectives for cadaver surgical training and medical device development

Nagase

Tokumine

et al. 2022

Anat Sci Int

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Excised human larynx in N-vinyl-2-pyrrolidone-embalmed cadavers can produce voiced sound by pliable vocal fold vibration

Cited by 3 publications

References 36 publications

Cadaver preserving methods – is it possible to do anything better?

Cadaver preserving methods – is it possible to do anything better?

Innovative Cadaver Preservation Techniques: a Systematic Review

Formalin-free soft embalming of human cadavers using N-vinyl-2-pyrrolidone: perspectives for cadaver surgical training and medical device development

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