Executive Decline and Dysfunction Precedes Declines in Memory: The Women's Health and Aging Study II

Carlson, Michelle C.; Qin, Xue; Zhou, Jing; Fried, Linda P.

doi:10.1093/gerona/gln008

Cited by 128 publications

(100 citation statements)

References 51 publications

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“…However, as reported above, it can be assumed that participants lost to follow-up assessments were somewhat older and more vulnerable to cognitive impairment resulting possibly in an underestimation of effects in the remaining sample. Yet, this limitation applies to most longitudinal studies [34,35]. Third, neuropsychological assessments and the evaluations of the person’s actual life circumstances including the ability to perform IADL independently can be regarded as highly reliable due to home visits by trained physicians and psychologists and additional interviews with close relatives or friends if cognitive function was impaired.…”

Section: Discussionmentioning

confidence: 99%

Malperformance in Verbal Fluency and Delayed Recall as Cognitive Risk Factors for Impairment in Instrumental Activities of Daily Living

Koehler

Kliegel²,

Wiese³

et al. 2011

Dement Geriatr Cogn Disord

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Background: Maintaining independence in instrumental activities of daily living (IADL) is crucial for older adults. This study explored the association between cognitive and functional performance in general and in single IADL domains. Also, risk factors for developing IADL impairment were assessed. Methods: Here, 3,215 patients aged 75–98 years were included. Data were collected during home visits. Results: Cognitive functioning was associated with IADL both cross-sectionally and longitudinally. Regarding the single IADL domains cross-sectionally, executive functioning was especially associated with shopping, while episodic memory was associated with responsibility for own medication. Conclusion: Reduced performance in neuropsychological tests is associated with a greater risk of current and subsequent functional impairment.

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Section: Discussionmentioning

confidence: 99%

Malperformance in Verbal Fluency and Delayed Recall as Cognitive Risk Factors for Impairment in Instrumental Activities of Daily Living

Koehler

Kliegel²,

Wiese³

et al. 2011

Dement Geriatr Cogn Disord

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“…Ageing is associated with decline in cognitive functions that are critical to independence, social engagement and quality of life. Unchecked, this normal and gradual deterioration can advance to clinical cognitive impairment which, in turn, carries a higher risk for progression to dementia (Caracciolo et al 2008;Carlson et al 2009;Gauthier et al 2006). It is estimated that, by 2050, dementia could affect some 106.2 million people globally (Brookmeyer et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of Functional Movement Training on Cognition and Emotion in the Elderly People

Li¹,

Fan²,

Wang³

et al. 2017

dtcse

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Existing literature documents that the physical exercise has positive effects on cognition and emotion function in elderly. However, whether the functional movement training will improve the cognition and emotion is remains obscure. We enrolled 58 subjects (65-75 years old) in this research and randomly divided as control group without training (CG) and the training group (TG). The training was performed twice a week and 90 min for every time during the 10 weeks. To estimate the change of cognition and emotion of elderly people, reaction time and spatial memory were tested, emotional scales were used. The results showed that there was no significant difference between the two groups before 10 weeks of training. After 10 weeks of training, the cognition and emotion of the training group was significant improvement when compared with control group and the cognition and emotion of training group was significant improvement than that before training. The functional movement training over 10 weeks can improve the cognition and emotion function in elderly people.

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“…Both attentional control mechanisms and EF deficits have been associated with the preclinical stages of dementia (Carlson et al, 2009;Harrington et al, 2013;Twamley et al, 2006). Frontal regions, the predominant neural focus of executive attention, are vulnerable early in the ageing trajectory to both a loss of neural integrity and the deposition of amyloid, with this pattern reported in both healthy and pathological ageing (Bartzokis et al, 2003;Raz, 2000;Rowe et al, 2007;Villemagne et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Lancaster

Tabet

Rusted

2016

Neurobiology of Aging

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Article (Accepted Version) http://sro.sussex.ac.uk Lancaster, Claire, Tabet, Naji and Rusted, Jennifer (2016) The APOE paradox: how do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline. Neurobiology of Aging, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/62415/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. AbstractPossession of an APOE e4 allele is an established risk factor for Alzheimer's disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. 66 volunteers, aged 45-55 years, completed three tasks that provided complementary measures of attentional control: prospective memory, sustained attention and inhibition. Performance was compared between e2 carriers, e4 carriers and e3 homozygotes (the population norm). Carriers of the e4 allele showed subtle disadvantages, compared to the e3 group, in accuracy of Stroop task and prospective memory performance. Contrary to expectations, e2 carriers showed performance disadvantages in sustained attention. The finding of detrimental effects in attentional control for both e4 and e2 complicates the current model that proposes opposing effects of these variants on later-life cognition. Future research is needed to understand how cognitive differences develop with increasing age, and the physiological mechanisms that underpin these changes.

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Executive Decline and Dysfunction Precedes Declines in Memory: The Women's Health and Aging Study II

Cited by 128 publications

References 51 publications

Malperformance in Verbal Fluency and Delayed Recall as Cognitive Risk Factors for Impairment in Instrumental Activities of Daily Living

Malperformance in Verbal Fluency and Delayed Recall as Cognitive Risk Factors for Impairment in Instrumental Activities of Daily Living

Effect of Functional Movement Training on Cognition and Emotion in the Elderly People

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

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